A5049198628- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diagnosis and treatment of tuberculosis
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Whipple's Disease and Interleukins
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Neonatal Respiratory Health Research
- S100 Proteins and Annexins
- Medicinal Plants and Neuroprotection
- Fatty Acid Research and Health
- Infectious Diseases and Tuberculosis
- Nanoparticles: synthesis and applications
- Immune Response and Inflammation
Universidade de São Paulo
2022-2024
Universidade do Oeste Paulista
2020-2022
chronic low-grade inflammation, or inflammaging, emerges as a crucial element in the aging process and is associated with cardiovascular neurological diseases, sarcopenia, malnutrition. Evidence suggests that omega-3 fatty acids present potential therapeutic agent prevention treatment of inflammatory mitigating oxidative stress, improving muscle mass, attributes are particularly relevant context aging. The objective study was to evaluate effectiveness supplementation fish oil immune response...
Airway epithelial cells (AEC) infected with SARS-CoV-2 may drive the dysfunction of macrophages during COVID-19. We hypothesized that direct interaction AEC mediated by CD95/CD95L or indirect IL-6 signaling are key steps for COVID-19 severe acute inflammation. The apoptotic and increased CD95 CD163 expression, induced macrophage death. Macrophages exposed to tracheal aspirate high levels from intubated patients recombinant human exhibited decreased HLA-DR expression IL-1β production. effects...
Abstract The alarmin S100 calcium-binding protein A9 (S100A9) plays a role in the immunopathology of lung diseases such as asthma and pneumonia. We hypothesized that acute pneumonia induced by S. pneumoniae exacerbates through S100A9 induction increase neutrophilic inflammation NET production. C57BL/6 Wild Type (WT) animals mice deficient for expression (S100A9 −/−) were sensitized challenged with ovalbumin (OVA) infected or not during challenge. In WT mice, comorbidity resulted significant...
Objective: Evaluate the severity of tuberculosis and its association with laboratory tests before antituberculosis treatment. Methodology: Patients pulmonary were evaluated for using data available in medical records (Clinical; Excretion mycobacteria; Diagnostic imaging) associated biochemical hematological parameters requested at time diagnosis Results: The evaluation showed a predominance smear AFB (+), fever other symptoms infiltrative tuberculosis. Only positive correlation between...
Alguns polimorfismos de base única (SNP) nos genes das citocinas apresentam potencialidade para afetar a expressão gênica e/ou atividade biológica da respectiva citocina, e existem evidências associação diferentes SNPs com tuberculose em diversas populações diferentes. Os estudos envolvendo influência no gene IL17A ainda são controversos, comportando-se forma variada entre populações. Desta forma, pesquisa evolução clínica doença, poderá contribuir um melhor entendimento susceptibilidade o...
Abstract Airway epithelial cells (AEC) are the first in contact with SARS-CoV-2 and drive interface macrophage to generate inflammation. To elucidate how those initial events contribute immunopathology or dysregulate immune response observed severe critical COVID-19, we determined direct indirect interactions of these cells. AEC lineage (Calu-3) infected (CD45 - EpCAM + ) from intubated COVID-19 patients showed high expression CD95L. Infected-Calu-3 secreted IL-6, expressed annexin V...