A5073648241- Retinal Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Advanced Glycation End Products research
- Hearing, Cochlea, Tinnitus, Genetics
- Mesenchymal stem cell research
- Veterinary Pharmacology and Anesthesia
- Neuroinflammation and Neurodegeneration Mechanisms
- Poisoning and overdose treatments
- Obesity, Physical Activity, Diet
- Air Quality and Health Impacts
- Olfactory and Sensory Function Studies
- Ear and Head Tumors
- Free Radicals and Antioxidants
- Angiogenesis and VEGF in Cancer
- Animal Nutrition and Physiology
- Retinopathy of Prematurity Studies
- Neuroendocrine regulation and behavior
- Photoacoustic and Ultrasonic Imaging
- Cancer, Hypoxia, and Metabolism
- Vestibular and auditory disorders
- Smoking Behavior and Cessation
- Retinal Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
- Heavy Metal Exposure and Toxicity
- Livestock and Poultry Management
University of Catania
2021-2025
Ospedale G.F. Ingrassia
2023
Diabetic retinopathy (DR) is characterized by morphologic and metabolic alterations in endothelial cells (ECs) pericytes (PCs) of the blood–retinal barrier (BRB). The loss interendothelial junctions, increased vascular permeability, microaneurysms, finally, EC detachment are main features DR. In this scenario, a pivotal role played extensive PCs. Based on previous results, aim study was to assess possible beneficial effects exerted adipose mesenchymal stem (ASCs) their pericyte-like...
The blood-retinal barrier (BRB) is strongly compromised in diabetic retinopathy (DR) due to the detachment of pericytes (PCs) from retinal microvessels, resulting increased permeability and impairment BRB. Western blots, immunofluorescence ELISA were performed on adipose mesenchymal stem cells (ASCs) pericyte-like (P)-ASCs by co-cultured human endothelial (HRECs) under hyperglycemic conditions (HG), as a model DR. Our results demonstrated that: (a) platelet-derived growth factor receptor...
Polychlorinated biphenyls (PCBs) are heterogeneous, synthetic, and widespread organochlorine compounds, one of the persistent organic pollutants present in improperly dumped waste electronic equipment (e-waste), with a high bioaccumulation potential. In this study, toxicity Aroclor 1254 (a mixture commercial PCBs) human corneal epithelial cells (HCEpiCs), an vitro model ocular barrier, was evaluated. (0.1–10 μg/mL) reduced cell viability, trans-endothelial electric resistance (TEER)...
Reactive oxygen species (ROS) accumulation plays a pivotal role in the onset of cell damage induced by hyperglycemia and represents one major factors pathogenesis diabetic retinopathy. In this study, we tested antioxidants cyanidin-3-O-glucoside (C3G) verbascoside (Verb) protection retinal endothelium against glucose toxicity "in vitro".Increasing amounts (5-50 μM) C3G, Verb or combination both compounds were Human Retinal Endothelial Cells (HREC) grown with normal (5 mM, NG) high (25...
Hypoxia compromises the integrity of blood-brain barrier (BBB) and increases its permeability, thereby inducing inflammation. Olfactory ensheathing cells (OECs) garnered considerable interest due to their neuroregenerative anti-inflammatory properties. Here, we aimed investigate potential modulatory effects OEC-conditioned medium (OEC-CM) on response human brain microvascular endothelial (HBMECs), constituting BBB, when exposed hypoxia. HBMECs were utilized establish in vitro BBB model. OECs...
The stria vascularis (SV) contributes to cochlear homeostasis and consists of three layers, one which contains the blood-labyrinthic barrier (BLB), with a large number bovine pericytes (BCPs). Cisplatin is chemotherapeutic drug that can damage SV cause hearing loss. In this study, cell viability, proliferation rate, cytotoxicity reactive oxygen species production were evaluated. protein content phospho-extracellular signal-regulated kinases (ERK) 1/2, total ERK phospho-cytosolic...
Hyperglycemia-induced impairment of the blood-retinal barrier represents main pathological event in diabetic retinopathy that is elicited by a reduced cellular response to an accumulation reactive oxygen species (ROS) and increased inflammation. The purpose study was evaluate whether selective β1-adrenoreceptor (β1-AR) antagonist metoprolol could modulate inflammatory hyperglycemic conditions. For this purpose, human retinal endothelial cells (HREC) were treated with normal (5 mM) or high...
Lignans, a class of secondary metabolites found in plants, along with their derivatives, exhibit diverse pharmacological activities, including antioxidant, antimicrobial, anti-inflammatory, and antiangiogenic ones. Angiogenesis, the formation new blood vessels from pre-existing ones, is crucial process for cancer growth development. Several studies have elucidated synergistic relationship between angiogenesis inflammation various inflammatory diseases, highlighting correlation vascular...
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Starting from the second week after birth, majority of piglets suffer iron-deficiency anemia, which leads to a decrease in innate immunity, slowing growth and increasing mortality. As consequence, many die at age 7‒10 days. Preliminary injections gamavit for on 3rd 8th day life doses 2 ml 3 per head, respectively, prevents development iron deficiency stimulates their development, increases survival 25th by 10.5%.
Gamavit and Phosprenyl