A5005073434- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- Plant nutrient uptake and metabolism
- Microtubule and mitosis dynamics
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Cell Image Analysis Techniques
- Photosynthetic Processes and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Bacterial Identification and Susceptibility Testing
- Polydiacetylene-based materials and applications
- Digital Imaging for Blood Diseases
Medical University of Vienna
2024
Tohoku University
2021
Molecular Oncology (United States)
2021
Max Planck Institute of Molecular Physiology
2021
Microscopy of stained blood smears is still a ubiquitous technique in pathology. It often used addition to automated electronic counters or flow cytometers evaluate leukocytes and their morphologies rather simple manner has low requirements for resources equipment. However, despite the constant advances microscopy, computer science, pathology, it usually follows traditional approach manual assessment by humans. We aimed extend this using AI-based cell recognition methods while maintaining...
Reconstituting artificial proto-cells capable of transducing extracellular signals into cytoskeletal changes can reveal fundamental principles how non-equilibrium phenomena in cellular signal transduction affect morphogenesis. Here, we generated a Synthetic Morphogenic Membrane System (SynMMS) by encapsulating dynamic microtubule (MT) aster and light-inducible signaling system driven GTP/ATP chemical potential cell-sized liposomes. Responding to light cues analogy morphogens, this biomimetic...
The activation of endothelial cells is crucial for immune defense mechanisms but also plays a role in the development atherosclerosis. We have previously shown that inflammatory stimulation on top elevated lipoprotein/cholesterol levels accelerates atherogenesis. aim current study was to investigate how chronic inflammation changes aortic transcriptome mice at normal lipoprotein and compare this response isolated vitro. applied mouse model expressing constitutive active IκB kinase 2...
Chromosome oscillation during metaphase is attenuated in cancer cell lines, concomitant with the reduction of Aurora A activity on kinetochores, which results reduced mitotic fidelity. To verify correlation between activity, chromosome oscillation, and error correction efficiency, we developed a mathematical model kinetochore-microtubule dynamics, based stochastic attachment/detachment events regulated by gradient centered at spindle poles. The accurately reproduced oscillatory movements...