A5078511868- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Mental Health Research Topics
- Glycosylation and Glycoproteins Research
- Digital Mental Health Interventions
- Peptidase Inhibition and Analysis
- Renal Diseases and Glomerulopathies
- TGF-β signaling in diseases
- Dementia and Cognitive Impairment Research
- Mindfulness and Compassion Interventions
- Cancer survivorship and care
- Personality Disorders and Psychopathology
- Treatment of Major Depression
- Olfactory and Sensory Function Studies
- Cancer-related cognitive impairment studies
- Family Caregiving in Mental Illness
- Enzyme Catalysis and Immobilization
- Neuropeptides and Animal Physiology
- Rheumatoid Arthritis Research and Therapies
- Genetic Syndromes and Imprinting
- Biosimilars and Bioanalytical Methods
- Music Therapy and Health
- Pregnancy and preeclampsia studies
Keio University
2018-2023
Kokura Memorial Hospital
2020
Juntendo University Hospital
2017
Fukuyama University
2005-2007
Chiba University
2005-2006
University of Tsukuba
1981-1987
DAF is a 70,000-Mr membrane protein that inhibits the amplification of complement cascade on cell surface, and protects cells from damage by complement. The precise mechanism action not entirely clear. Purified was incorporated into EAC4b cells. EAC4b2 EDAF AC4b2 were prepared with radiolabeled C2. same amount labeled C2 bound to both cells, showing does prevent binding zymogen C4b. After adding Cl, radioactivity dissociated more rapidly AC4b than In converted C2a, which gradually...
Background Meta-analyses of several randomized controlled trials have shown that cognitive behavioral therapy (CBT) has comparable efficacy to antidepressant medication, but therapist availability and cost-effectiveness is a problem. Objective This study aimed evaluate the effectiveness Web-based CBT blended with face-to-face sessions reduce time in patients major depression who were unresponsive medications. Methods A 12-week, assessor-masked, parallel-group, waiting- list controlled, trial...
We investigated the effect of a pH 4-treated human immunoglobulin preparation for intravenous use (pH4-G) on production tumor necrosis factor alpha (TNF-alpha) in vivo. The level TNF-alpha sera rabbits receiving pH4-G before lipopolysaccharide (LPS) injection was lower than that only LPS. Similarly, vitro suppressed by pH4-G. Rabbit peritoneal exudate cells stimulated with LPS presence produced less did those pH4-G, however, had no various activities, such as cytotoxicity against tumorigenic...
Immune precipitates were solubilized by the alternative pathway of complement assembled from isolated proteins, i.e., C3, factor B, D, properdin, C3b inactivator (C3bINA), and beta 1H. The kinetic curves solubilization in system EGTA-serum virtually indistinguishable. No requirement other factors was apparent. Deletion C3bINA 1H complete mixture caused total consumption C3 fluid phase resulted neither binding to complexes nor solubilization. Thus, presence a regulated fluid-phase reaction is...
Purified C4-binding protein (C4-bp) was shown to bind cell-bound C4b by radioactive tracer techniques. With EAC4 bearing greater than 3,000 C4b-molecules/cell, the number of C4-bp molecules bound directly proportional molecule on cell surface; less C4b-molecules/cell a very small amount C4-bp. Scatchard analysis binding indicated an equilibrium constant 4.6 X 10(8) L/M and maximum 0.43 per molecule, equivalent average one two or three C4b. Fluid-phase inhibited in dose-dependent manner,...
Sexual dimorphism of mouse complement component 5 (C5) was detected by isoelectric focusing desialated ethylenediamine tetraacetic acid (EDTA)-plasma on agarose gel, followed immunofixation with anti-mouse C5. Male plasma displayed two C5 bands, basic and acidic, while female had only a band. In all strains tested except C5-deficient strains, the identical patterns were obtained. The acidic antigenically hemolytically indistinguishable from each other. neonatal mice both sexes, observed at...
We prepared mouse monoclonal antibodies to human C4-binding protein (C4-bp) by fusing spleen cells from mice immunized with purified C4-bp the myeloma line P3U1. Of four that reacted intact C4-bp, two were specific for a 48K fragment, one of chymotryptic cleavage products and was another fragment (160K). The fourth antibody did not react either fragment. One monoclonals blocked binding cell-bound C4b. This (TK3) also inhibited other functions serving as an essential cofactor C3b/C4b...
To evaluate the effect of growth factor activin A on secretion prolactin (PRL) and GH in cultured GH3 cells.The concentrations PRL secreted from cells media with without were measured by RIA, expression mRNA analyzed using Northern blot method.Activin significantly inhibited release for 48h a dose-dependent manner (activin: 0.3-3nM). The inhibitory effects 3nM observed culture 12h to (53.2% control). Activin (3nM) also at 24h (33.8% In contrast, stimulated stimulatory was (157.6% (183.6%...
A 62-year-old woman with axonal Guillain-Barré syndrome developed weakness and urinary retention simultaneously. The failed to recover for 10 months even after she regained the ability walk. patient exhibited no postural hypotension. Videourodynamics showed that was caused not by bladder paralysis but rather internal (sympathetic) sphincter obstruction, which is extremely uncommon in peripheral neuropathies. We started on an alpha-adrenergic antagonist, urapidil, at 30 mg/day, this led...
Abstract Objectives To deliver mindfulness-based cognitive therapy (MBCT) efficiently, the present study aimed (1) to identify predictors and moderators of patients who benefit from MBCT for psychological distress (2) explore initial treatment reaction optimal number sessions that produce a significant clinical effect. Methods This is secondary analysis randomized controlled trial breast cancer ( N = 74). We classified participants into remitters vs. non-remitters, responder non-responders,...
<h3>Background</h3> Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). Efficacy and safety tofacitinib have been shown in RA patients global Phase 2, 3 (one study included Japanese patients) long-term extension (LTE) studies two 2 one LTE patients. <h3>Objectives</h3> We evaluated following drug approval with using all-case post-marketing surveillance (PMS) data. <h3>Methods</h3> A 6-month interim analysis data from ongoing 3-year PMS was conducted (5 Nov...
Abstract Background Caregivers of people with dementia frequently experience an elevated level psychological distress and burden. This study aimed to examine the effectiveness a group‐format multi‐component programme which is based on cognitive behavioural therapy positive psychology. Methods Family caregivers were allocated (1:1) intervention group wait‐list control group, stratified by age (<65 years, ≥65 years) care status (at home or in institution). The received six‐session, 10‐week,...
Parker et al. (2006) proposed a new approach to classify specific sub-types of non-melancholic depression caused by various stress factors and premorbid personality styles: the Temperament Personality Questionnaire (T&P). The current study aim was develop Japanese version T&P evaluate its reliability validity.We studied 114 patients with depression. Reliability assessed using test-retest method. Convergent validity compared clinician ratings each patient for eight traits. We also impact...