A5075629807- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Bariatric Surgery and Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacology and Obesity Treatment
- Pancreatitis Pathology and Treatment
- Gestational Diabetes Research and Management
- Neurological Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Blood Pressure and Hypertension Studies
- Helicobacter pylori-related gastroenterology studies
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Education, Psychology, and Social Research
- Eosinophilic Esophagitis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- IL-33, ST2, and ILC Pathways
- Bone health and osteoporosis research
Institute of Clinical and Experimental Medicine
2018-2025
Charles University
2018-2022
General University Hospital in Prague
2019-2021
Centre of Experimental Medicine of the Slovak Academy of Sciences
2019
Institute of Endocrinology
2018
Comenius University Bratislava
1992-2008
ABSTRACT Background Diabetes mellitus (DM) significantly impacts global health and economies. Despite various therapies, managing DM remains challenging. Bariatric surgery has shown efficacy in obese patients with type 2 diabetes (T2DM), but its utilization low. Innovative, less invasive endoscopic approaches such as duodenal mucosal resurfacing show potential treating T2DM. This article presents the results of a First Human (FIH) study using submucosal laser ablation investigational device...
Abstract Background Angiopoietin-like proteins (ANGPTLs) 3 and 4 are circulating factors that participate in the regulation of lipid glucose metabolism. Subjects methods We measured serum ANGPTL3 levels 23 patients with obesity, 40 obesity type 2 diabetes mellitus (T2DM), 22 anorexia nervosa (AN), 15 subjects undergoing 72-h fasting, 12 short bowel syndrome (SBS), their changes after very-low-calorie diet (VLCD), bariatric surgery, partial realimentation, acute parenteral nutrition order to...
Abstract Background Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are glucose-lowering agents used for the treatment of type diabetes mellitus, which also improve heart failure and decrease risk cardiovascular complications. Epicardial adipose tissue (EAT) dysfunction was suggested to contribute development failure. We aimed elucidate a possible role changes in EAT metabolic inflammatory profile beneficial cardioprotective effects SGLT-2i subjects with severe Methods 26 failure,...
Abstract Background Cachexia worsens long‐term prognosis of patients with heart failure (HF). Effective treatment cachexia is missing. We seek to characterize mechanisms in adipose tissue, which could serve as novel targets for the treatment. Methods The study was conducted advanced HF ( n = 52; 83% male patients) undergoing transplantation. Patients ≥7.5% non‐intentional body weight (BW) loss during last 6 months were rated cachectic. Clinical characteristics and circulating markers...
(1) Background: empagliflozin, sodium-glucose co-transporter 2 (SGLT-2) inhibitor, is an effective antidiabetic agent with strong cardio- and nephroprotective properties. The mechanisms behind its nephroprotection are still not fully clarified. (2) Methods: we used male hereditary hypertriglyceridemic (hHTG) rats, a non-obese model of dyslipidaemia, insulin resistance, endothelial dysfunction fed standard diet or without empagliflozin for six weeks to explore the molecular effects. Nuclear...
Dendritic cells (DCs) are professional antigen-presenting contributing to regulation of lymphocyte immune response. DCs divided into two subtypes: CD11c-positive conventional or myeloid (cDCs) and CD123-positive plasmacytoid (pDCs) DCs. The aim the study was assess (HLA-DR+ lineage-) their subtypes by flow cytometry in peripheral blood subcutaneous (SAT) epicardial (EAT) adipose tissue subjects with (T2DM, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
We measured plasma concentrations, adipose tissue and placental mRNA expression of hepatokines fetuin A, B fibroblast growth factor 21 (FGF21) in 12 healthy pregnant women (P group), with gestational diabetes (GDM) 10 non-pregnant (N group) to explore their potential role the etiopathogenesis GDM. GDM P group had comparable BMI, C-reactive protein (CRP) glycated hemoglobin levels while IL-10 TNF-alpha were higher group. Fetuin A pregnancy as compared N decreased after delivery no apparent...
Immunocompetent cells including lymphocytes play a key role in the development of adipose tissue inflammation and obesity-related cardiovascular complications. The aim study was to explore relationship between epicardial coronary artery disease (CAD). To this end, we studied content phenotype peripheral blood, subcutaneous (SAT), (EAT) subjects with without CAD undergoing elective cardiac surgery. Eleven (non-CAD group) 22 age-, BMI-, HbA 1C -matched individuals were included into study....
Abstract Context Impaired glucose homeostasis is a common finding in pheochromocytoma (PHEO), especially with adrenergic phenotype. The possible contribution of incretin dysfunction to dysglycemia PHEO patients has not been studied. Objective To compare changes pancreatic endocrine function and gut hormones’ production during liquid meal test before 1 year after adrenalectomy. Methods In prospective study, we included 18 (13 females) biochemical A predefined isocaloric enteral nutrition was...
Abstract Context Gestational diabetes mellitus (GDM) is accompanied by subclinical inflammation; however, little known about local inflammation in adipose tissue and placenta. Objective To analyze systemic lymphocyte content phenotype pregnant women with without GDM. Design Observational study. Settings Academic hospital. Patients Twenty-one GDM (GDM group), 16 (non-GDM group) 15 nonpregnant control (N group). Interventions Serum samples taken at 28 to 32 (visit 1 [V1]) 36 38 (V2)...
Omentin is a protein produced by numerous tissues including adipose tissue. Its concentrations are decreased in patients with obesity, type 2 diabetes mellitus (DM) and coronary artery disease (CAD). Experimental studies suggest that omentin may have anti-inflammatory insulin-sensitizing properties. In the present study, we measured circulating levels its mRNA expression epicardial subcutaneous fat, intercostal heart muscle before after elective cardiac surgery CAD (CAD+, DM-, n=18),...
The insulin-like growth factor (IGF) is involved in the regulation of and metabolism. aim this study was to determine selected parameters IGF system at systemic local levels [subcutaneous (SAT) visceral adipose tissue (VAT)] assess its possible role gestational diabetes mellitus (GDM). 37 pregnant women (21 with GDM 16 without GDM) 15 age-matched non-pregnant females were included study. Blood samples taken 28-32 36-38 weeks gestation 6-12 months after delivery. SAT VAT obtained during...
Coronary artery disease is one of the most frequent causes morbidity and mortality worldwide. It even more prevalent in patients with type 2 diabetes mellitus who suffer from obesity increased accumulation epicardial fat a possible contributing role development coronary disease. We performed an MS-based lipidomic analysis subcutaneous adipose tissue 23 stratified for presence/absence control group 13 subjects aiming at identification factors to The samples tissues were obtained during...
Neudesin has recently been identified as a novel regulator of energy expenditure in experimental animals; however, its role humans remains unexplored.The aim this study was to assess the effects obesity and type 2 diabetes mellitus (T2DM) along with selected weight reducing interventions on serum neudesin levels adipose tissue mRNA expression.Fifteen obese subjects T2DM undergoing endoscopic duodenal-jejunal bypass liner (DJBL) implantation, 17 (11 T2DM, 6 without T2DM) scheduled for gastric...
Insulin-like growth factors (IGFs) are involved in regulating and metabolism increase insulin sensitivity, improve glucose metabolism, potentially related to gestational diabetes mellitus (GDM) its complications for mothers fetuses.This study aimed assess serum levels cord blood of IGF system components pregnant women with (39 participants) without GDM (22 participants). Blood samples were obtained at 28-32 36-38 weeks gestation 6-12 months after delivery. Cord during Results between both...
Endothelial damage, platelet hyperactivity and other changes of blood coagulation may play a role in the vascular complications essential hypertension. Undesirable haemostasis induced by some anti-hypertensive drugs can encourage acceleration atherogenesis. Therefore, effect angiotensin-converting enzyme (ACE)-inhibitors on is interest. The therapeutic dose perindopril was previously shown to reduce aggregation. In present study, selected parameters were investigated 23 patients with first...
The duodenum has recently emerged as a key regulator in glucose metabolism via modulation of complex network neural and hormonal signals response to ingested food. DiaGone™ is an endoscopic device which utilizes precisely controlled laser technology target the duodenal submucosal plexi with aim improving control by modulating gastrointestinal neurohumoral axis. Nine subjects (5 males) obesity (BMI 34.0 ± 4.6 kg/m2) type 2 diabetes mellitus (T2DM) insufficiently on metformin were included...