A5054285684- BRCA gene mutations in cancer
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Bone Tumor Diagnosis and Treatments
- Metastasis and carcinoma case studies
- Diabetic Foot Ulcer Assessment and Management
- Pleural and Pulmonary Diseases
- PARP inhibition in cancer therapy
- Infectious Diseases and Tuberculosis
- Dietary Effects on Health
- Augmented Reality Applications
- Orthopedic Infections and Treatments
- Pharmacology and Obesity Treatment
- Neutropenia and Cancer Infections
- Melanoma and MAPK Pathways
- Sarcoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Genetic Associations and Epidemiology
- Sports and Physical Education Studies
- Gastrointestinal motility and disorders
- Orthopedic Surgery and Rehabilitation
- Tendon Structure and Treatment
Charles University
2020-2025
Institute of Clinical and Experimental Medicine
2021-2025
General University Hospital in Prague
2022-2024
University of West Bohemia
2017
Czech Academy of Sciences
1979
ABSTRACT Background Diabetes mellitus (DM) significantly impacts global health and economies. Despite various therapies, managing DM remains challenging. Bariatric surgery has shown efficacy in obese patients with type 2 diabetes (T2DM), but its utilization low. Innovative, less invasive endoscopic approaches such as duodenal mucosal resurfacing show potential treating T2DM. This article presents the results of a First Human (FIH) study using submucosal laser ablation investigational device...
Ovarian cancer (OC) is the deadliest gynecologic malignancy with a substantial proportion of hereditary cases and frequent association breast (BC). Genetic testing facilitates treatment preventive strategies reducing OC mortality in mutation carriers. However, prevalence germline mutations varies among populations many rarely mutated predisposition genes remain to be identified. We aimed analyze 219 1333 Czech patients 2278 population-matched controls using next-generation sequencing....
Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. The present study aimed to determine frequency of germline pathogenic variants (PV) patients with EC. In this multicenter retrospective cohort study, genetic testing (GGT) was performed 527 EC using a next generation sequencing panel targeting 226 genes, including 5 Lynch syndrome (LS) and 14 hereditary breast ovarian (HBOC) predisposition 207 candidate genes. Gene-level risks were calculated 1,662...
(1) Background: The proportion and spectrum of germline pathogenic variants (PV) associated with an increased risk for pancreatic ductal adenocarcinoma (PDAC) varies among populations. (2) Methods: We analyzed 72 Belgian 226 Czech PDAC patients by multigene panel testing. prevalence in relation to personal/family cancer history were evaluated. risks calculated using both gnomAD-NFE population-matched controls. (3) Results: In 35/298 (11.7%) a PV established PDAC-predisposition gene was...
Cutaneous melanoma is the deadliest skin malignity with a rising prevalence worldwide. Patients carrying germline mutations in melanoma-susceptibility genes face an increased risk of and other cancers. To assess spectrum variants, we analyzed 264 Czech patients indicated for testing due to early (at <25 years) or presence multiple primary melanoma/melanoma cancer their personal and/or family history. All were by panel next-generation sequencing targeting 217 four groups: high-to-moderate...
Hepatocellular carcinoma (HCC) mainly stems from liver cirrhosis and its genetic predisposition is believed to be rare. However, two recent studies describe pathogenic/likely pathogenic germline variants (PV) in cancer-predisposition genes (CPG). As the risk of de novo tumors might increased PV carriers, especially immunosuppressed patients after a transplantation, we analyzed prevalence CPG HCC considered for transplantation. Using panel NGS targeting 226 CPGs, DNA 334 Czech 1662...
The polygenic risk score (PRS) allows the quantification of effect many low-penetrance alleles on breast cancer (BC). This study aimed to evaluate performance two sets comprising 77 or 313 loci (PRS77 and PRS313) in patients with BC Czech population.
Monoallelic germline pathogenic variants (GPVs) in five Fanconi anemia (FA) genes (BRCA1/FANCS, BRCA2/FANCD1, PALB2/FANCN, BRIP1/FANCJ, and RAD51C/FANCO) confer an increased risk of breast (BC) and/or ovarian (OC) cancer, but the role GPVs 17 other FA remains unclear.
The authors deal with an extension and modification of construction kits in order to create a simple tool for assessing the level creativity according products made by pupils. article describes modified set – creative set, divided into system non-system parts. In context product design, use parts indicates pupil"s performance. was tested out on sample 62 elementary school Subsequently, put analyse.
Obezita je závažné onemocnění, jehož incidence nadále celosvětově roste. Onemocnění asociovaná s obezitou vedou ke snížení kvality života a vyšší mortalitě (vysoký krevní tlak, dyslipidemie, diabetes mellitus 2. typu další). Léčba obezity multidisciplinární komplexní proces, který vyžaduje důslednou spolupráci pacienta. Změna životního stylu stavebním kamenem úspěšné terapie obezity. Farmakologická zažívá v posledních letech renesanci její role, jak už monoterapii, tak i kombinaci jinými...