A5102004780- Virology and Viral Diseases
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
Heilongjiang Bayi Agricultural University
2023-2025
Ministry of Agriculture and Rural Affairs
2023
Canine distemper virus (CDV) is a member of the genus Morbillivirus with worldwide distribution that causes fatal diseases in canids and marine mammals. In recent years, CDV has demonstrated remarkable ability pathogens to cross species barriers. The natural host range expanded from Canidae Primates, presumably attributed ecological shifts emergence viral variants. Therefore, it important investigate whether can infect humans by adapting human signalling lymphocyte activation molecule...
Canine distemper (CD), caused by canine virus (CDV), is a highly contagious and lethal disease in domestic wild carnivores. Although CDV live-attenuated vaccines have reduced the incidence of CD worldwide, low levels protection are achieved presence maternal antibodies juvenile animals. Moreover, may retain residual virulence susceptible species cause disease. Here, we generated several DNA vaccine candidates based on biscistronic vector (pIRES) co-expressing wild-type or codon-optimized...