A5101494063- Viral-associated cancers and disorders
- Mosquito-borne diseases and control
- Retinal Imaging and Analysis
- Viral Infections and Vectors
- Parvovirus B19 Infection Studies
- Virology and Viral Diseases
- Immune Cell Function and Interaction
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Acute Lymphoblastic Leukemia research
- Pneumonia and Respiratory Infections
- Retinal Diseases and Treatments
- Adenosine and Purinergic Signaling
- Nuclear Receptors and Signaling
- Glaucoma and retinal disorders
- Acute Myeloid Leukemia Research
- Genetics and Neurodevelopmental Disorders
- Natural product bioactivities and synthesis
- Hematological disorders and diagnostics
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Immunology Research
- Autoimmune and Inflammatory Disorders Research
- Malaria Research and Control
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
Capital Medical University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Beijing Children’s Hospital
2020-2025
Shandong First Medical University
2025
Chinese Academy of Agricultural Sciences
2025
Endocrinology Research Center
2024
First Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
Center for Children
2022-2023
Tsinghua University
2015-2022
Rapid and sensitive detection of biomarkers with ultralow concentrations remains a great challenge in disease diagnostics. Herein, we present label-free α-hemolysin (α-HL) nanopore proximity bioassay for protein biomarker by binding-induced DNA strand displacement strategy. In this bioassay, an individual target protein, platelet-derived growth factor B-chain (PDGF-BB), was selectively recognized two oligonucleotide affinity ligands which output released translocated through α-HL spikelike...
Background Congenital TORCH ( Toxoplasma gondii (T . gondii) , rubella virus (RV), cytomegalovirus (CMV), and herpes simplex (HSV)) infections are associated with a variety of adverse prenatal neonatal events, including miscarriage, malformations developmental abnormalities, they remain an issue that cannot be neglected in China. However, the current research focuses more on general screening women childbearing age, medical information children hospitalized due to congenital perinatal has...
Building-integrated photovoltaic (BIPV) façades are a promising technique for improving building energy performance. This study develops simulation models of different photovoltaic-integrated shading devices (PVSDs) in single-story and multi-story office buildings. A cross-region China is carried out to explore the performance PVSDs five climate zones. The effect upper taken into account. results show that (1) can be applicable hot cold climates; effects lead notable difference optimal...
Epstein–Barr virus (EBV) infection is extremely common worldwide, with approximately 90% of adults testing positive for EBV antibodies. Human are susceptible to infection, and primary typically occurs early in life. can cause infectious mononucleosis (IM) as well some severe non-neoplastic diseases, such chronic active (CAEBV) EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), which have a heavy disease burden. After individuals develop robust EBV-specific T cell immune responses,...
Abstract Background Epilepsy is a common neurological disorder. The homologous to E6-AP carboxy terminus (HECT) E3 ligase associated with epilepsy. NEDD4-like ubiquitin protein ligase-1 (NEDL1) HECT that highly expressed in the brain. This study aimed investigate involvement of NEDL1 epilepsy and potential effect on cognitive ability. Methods pilocarpine-induced epileptic mouse model was used assess functions Barnes maze, pathological changes, activation astrocytes microglia wild-type (...
To explore the symptom clusters of patients undergoing maintenance hemodialysis and construct a network to identify core symptoms clusters, provide reference for precise management. Conveniently selected 354 with were surveyed cross-sectionally using general information questionnaire, Dialysis Symptom Index Kidney Disease Questionnaire. extracted exploratory factor analysis, identified hierarchical regression analysis. The most common severe fatigue, dry skin itching, distressing itching...
Canine distemper virus (CDV) is a member of the genus Morbillivirus with worldwide distribution that causes fatal diseases in canids and marine mammals. In recent years, CDV has demonstrated remarkable ability pathogens to cross species barriers. The natural host range expanded from Canidae Primates, presumably attributed ecological shifts emergence viral variants. Therefore, it important investigate whether can infect humans by adapting human signalling lymphocyte activation molecule...
Community acquired pneumonia (CAP) is a major global public health concern among children, with viral pathogens playing significant role. Despite this, national multicenter studies on community (VCAP) in hospitalized children remain scarce. The study employed approach to investigate the clinical epidemiology and burden of VCAP across China. Data were extracted from face sheets discharge medical records (FSMRs) within FuTang Update Medical Records (FUTURE) database, spanning 2016 2022. cases...
Epstein-Barr virus (EBV) is very common, with the infection rate in adults over 90% worldwide. Infectious mononucleosis (IM) caused by primary EBV. Most IM patients are generally considered to have a favorable prognosis, but few will also develop complications. Children severe symptoms require hospitalization. However, disease burden of children hospitalized China has been rarely described. In this study, we included Face sheets discharge medical records from 27 member children's hospitals...
Background Viruses of the family Flaviviridae , including Japanese encephalitis virus (JEV), dengue (DENV), yellow fever (YFV) and hepatitis C (HCV), are widely distributed worldwide. JEV, DENV YFV belong to genus Flavivirus whereas HCV belongs Hepacivirus . Children’s symptoms usually severe. As a result, rates hospitalization due infection with these viruses high. The epidemiology disease burden hospitalized children have rarely been described in detail date. objective this study was...
This multicenter clinical trial was conducted to examine current practice of benign epilepsy with centrotemporal spikes and especially address the question that in what circumstances 1 antiepileptic drug (AED) should be preferred. Twenty-five medical centers participate this trial. The general information, treatment status were collected under guidance clinicians then analyzed. Difference between different groups compared, usefulness most commonly used AEDs evaluated. A total 1817 subjects...
Background: Locally advanced breast cancer (LABC) is one of the subgroups invasive cancer. The treatment LABC neoadjuvant chemotherapy (NAC) before surgery, which different from others. study aimed to analyze and compare characteristics conventional ultrasound, contrast-enhanced ultrasonography (CEUS) strain elastography (SE) in patients who have outcomes, provide help for imaging diagnosis clinic treatment. Methods: From May 2018 April 2019, 36 (40 lesions) were enrolled, diagnosed by...
The efficacy and safety of venetoclax in newly diagnosed pediatric acute myeloid leukemia (AML) are not well-established as they adults. Children with AML were recommended for induction therapy chemotherapy or hypomethylating agents (HMAs) per the ChiCTR1900027146 trial. Venetoclax was administered at a consistent dose 200 mg/m
Canine distemper (CD), caused by canine virus (CDV), is a highly contagious and lethal disease in domestic wild carnivores. Although CDV live-attenuated vaccines have reduced the incidence of CD worldwide, low levels protection are achieved presence maternal antibodies juvenile animals. Moreover, may retain residual virulence susceptible species cause disease. Here, we generated several DNA vaccine candidates based on biscistronic vector (pIRES) co-expressing wild-type or codon-optimized...
An increasing number of laboratories need to collect data from multiple flow cytometers, especially for research projects performed across centers. The challenges using two cytometers in different labs include the lack standardized materials, software compatibility issues, inconsistencies instrument setup, and use configurations cytometers. To establish a cytometry experiment achieve consistency comparability experimental results centers, rapid feasible standardization method was established...
A non-mydriasis optical system for binocular fundus camera has been designed in this paper. It can capture two images of the same retinal region from different angles at time, and be used to achieve three-dimensional reconstruction fundus. is composed imaging illumination system. In system, Gullstrand Le Grand eye model simulate normal human eye, Schematic test influence ametropia on quality. Annular aperture black dot board are added into so that eliminate stray light produced by...
Abstract Aims Abundant recent evidence has shown that 3‐phosphoinositide‐dependent protein kinase 1 (PDK1) is activated in Alzheimer's disease (AD). However, it remains unknown whether inhibition of PDK1 neurons may affect AD‐like pathology animal models AD. Here, we aim to examine the effects specific inactivation neuronal on and behaviour 5×FAD mice identify underlying molecular mechanisms. Methods The Cre‐loxP system was employed generate Pdk1 cKO/5×FAD mice, which inactivated excitatory...