A5101620616- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Imaging and Diagnostics
- Parathyroid Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Protein Degradation and Inhibitors
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Mental Health Research Topics
- Eosinophilic Disorders and Syndromes
- Advanced X-ray and CT Imaging
- Advanced biosensing and bioanalysis techniques
- Hemoglobinopathies and Related Disorders
- Protein Kinase Regulation and GTPase Signaling
- Sarcoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Tryptophan and brain disorders
- Cancer-related cognitive impairment studies
- COVID-19 Clinical Research Studies
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Health, psychology, and well-being
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
Affiliated Hospital of Taishan Medical University
2025
Shandong First Medical University
2025
Huazhong University of Science and Technology
2023-2024
Tongji Hospital
2023-2024
Foghorn Therapeutics (United States)
2023
Zhongnan Hospital of Wuhan University
2021-2022
Wuhan University
2021-2022
Background: Accumulating evidence has revealed that coronavirus disease 2019 (COVID-19) patients may be complicated with myocardial injury during hospitalization. However, data regarding persistent cardiac involvement in who recovered from COVID-19 are limited. Our goal is to further explore the sustained impact of follow-up, focusing on patients. Methods: In this prospective observational follow-up study, we enrolled a total 40 (20 and 20 without hospitalization) were discharged Zhongnan...
To explore the symptom clusters of patients undergoing maintenance hemodialysis and construct a network to identify core symptoms clusters, provide reference for precise management. Conveniently selected 354 with were surveyed cross-sectionally using general information questionnaire, Dialysis Symptom Index Kidney Disease Questionnaire. extracted exploratory factor analysis, identified hierarchical regression analysis. The most common severe fatigue, dry skin itching, distressing itching...
A lack of identified core symptom clusters in digestive cancer patients hinders achieving precision intervention. There are few studies on identifying based network analysis.
Objective: To investigate the left atrial (LA) changes in immunoglobulin light-chain cardiac amyloidosis (AL-CA) patients with different risk stratifications and to explore correlation between LA function degree of amyloid load using magnetic resonance (CMR) imaging. Methods: Forty-three AL-CA were retrospectively enrolled divided into low-to-moderate-risk group (n = 16, increased NT-proBNP or troponin I, both normal) high-risk 27, I). 20 healthy individuals matched for age gender included....
Abstract Acute myeloid leukemia (AML) is a complex disease with multiple sub-types, each characterized by unique clinical and molecular features, driving the need to develop targeted therapies which exploit specific vulnerabilities. Bromodomain-containing protein 9 (BRD9) component of ncBAF chromatin remodeling complex, has been recently indicated as strong dependency in AML (Weisberg et al 2022). It shown that inhibitors BRD9 induce growth inhibition expression apoptotic makers cell lines...
Amyloid overload and microcirculation impairment are both detrimental to left ventricular (LV) systolic function, while it is not clear which factor dominates LV functional remodeling in patients with cardiac amyloidosis (CA). The purpose of this study was investigate the major dysfunction using magnetic resonance imaging.Forty CA 20 healthy controls were included study. group divided into two subgroups by ejection fraction (LVEF): reduced LVEF (LVEF < 50%, rLVEF), preserved ≥ pLVEF)....
To investigate the relationship between epicardial adipose tissue (EAT) thickness using cardiac magnetic resonance imaging (CMR) and arrhythmias in hypertensive patients.
Automated CMR perfusion maps enable quantification of MBF for detection myocardial ischaemia rapidly within a clinical workflow. Stress derived quantitative parameters had good to excellent reproducibility, as well MPR was moderately correlated with semi-quantitative MPR. Quantitative provides objective indices (MBF and MPR), which could better identify disease extent detect coronary microvascular than visual interpretation.
Purpose: The study aimed to investigate the potential utility of left atrial (LA) strain by using cardiac magnetic resonance feature-tracking (CMR-FT) predict ventricular reverse remodeling (LVRR) following ST-segment elevation myocardial infarction (STEMI). Materials and Methods: Patients with a first STEMI treated primary percutaneous coronary intervention were consecutively enrolled in prospective underwent CMR scans at 5 days 4 months. LA global longitudinal (reservoir [εs], conduit...
Motivation: Few studies have assessed the association of left atrial (LA) strain with ventricular reverse remodeling (LVRR) after ST-segment elevation myocardial infarction (STEMI). Goal(s): To investigate potential utility LA by using cardiac magnetic resonance feature-tracking (CMR-FT) to predict LVRR following STEMI. Approach: The prospective study analyzed patients a first STEMI and two CMR scans at 5 days 4 months, quantified CMR-FT cine images. Results: reservoir conduit strain,...
Multiple myeloma (MM) is a hematological malignancy of plasma cell origin. Cardiac amyloidosis (CA) common form heart damage caused by MM and associated with poor prognosis. This study was prospective cohort aimed at evaluating the clinical predictive value extracellular volume fraction (ECV) based on cardiovascular magnetic resonance (CMR) T1 mapping for cardiac dysfunction in patients. Fifty-one newly diagnosed patients Zhongnan Hospital Wuhan University were enrolled study. A total 19...
Abstract Bromodomain-containing protein 9 (BRD9) represents a potential selective vulnerability for tumors with specific alterations in the Brahma-associated factor (BAF) chromatin remodeling complex. One example of such modification is incorporation SS18-SSX fusion into BAF complexes. This alteration hallmark synovial sarcoma, and thought to drive tumorigenesis. As BRD9 subunit unique ncBAF, that depend on ncBAF survival may be susceptible degradation. Accordingly, degradation therapeutic...