A5038679986- Nutritional Studies and Diet
- Osteoarthritis Treatment and Mechanisms
- Systemic Lupus Erythematosus Research
- Lung Cancer Treatments and Mutations
- Bone and Joint Diseases
- Fatty Acid Research and Health
- Radiopharmaceutical Chemistry and Applications
- Rheumatoid Arthritis Research and Therapies
- Hepatitis C virus research
- Cancer Risks and Factors
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Virus-based gene therapy research
- Bone health and osteoporosis research
- Child Nutrition and Feeding Issues
- Gestational Diabetes Research and Management
- Viral Infectious Diseases and Gene Expression in Insects
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Hip disorders and treatments
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
Brigham and Women's Hospital
2019-2023
Harvard University
1997-2023
Mécanismes de Tumorigenèse et Thérapies Ciblées
2018
Centre National de la Recherche Scientifique
2009-2018
Université de Lille
2009-2018
Institut Pasteur de Lille
2009-2018
Beth Israel Deaconess Medical Center
2017
Institut de Biologie de Lille
2009-2015
Onco Lille
2015
Dana-Farber Cancer Institute
1997
Clinical isolates of primate immunodeficiency viruses, including human virus type 1 (HIV-1), enter target cells by sequential binding to CD4 and the chemokine receptor CCR5, a member seven-transmembrane family. HIV-1 variants which use additional receptors are present in central nervous system or emerge during course infection. Simian viruses (SIV) have been shown CCR5 as coreceptor, but no other for these identified. Here we show that two orphan segment receptors, gpr1 gpr15, serve...
The ETS transcription factor ETV4 is involved in the main steps of organogenesis and also a significant mediator tumorigenesis metastasis, such as breast cancer. Indeed, overexpressed tumors associated with distant metastasis poor prognosis. However, cellular molecular events regulated by this are still misunderstood. In mammary epithelial cells, controls expression many genes, MMP13 among them. aim study was to understand function during ETV4-driven tumorigenesis. Different constructs gene...
// Rachel Deplus 1 , Carine Delliaux Nathalie Marchand Anne Flourens Vanpouille Xavier Leroy 2 Yvan de Launoit Martine Duterque-Coquillaud University Lille, CNRS, Institut Pasteur UMR 8161 (M3T) Mechanisms of Tumorigenesis and Target Therapies, F-59000 France Pathologie Centre Biologie Hospitalier Régional et Universitaire, F-59037 Correspondence to: Duterque-Coquillaud, email: Martine.Duterque@ibl.cnrs.fr Deplus, rdeplus@ibl.cnrs.fr Keywords: TMPRSS2-ERG, prostate cancer, bone metastasis,...
To investigate passive smoking throughout the life course and risk of rheumatoid arthritis (RA), while accounting for personal smoking.We analyzed Nurses' Health Study II prospective cohort, using information collected via biennial questionnaires. We assessed influence 1) maternal during pregnancy (in utero exposure), 2) childhood parental smoking, 3) years lived with smokers since age 18. Incident RA serostatus were determined by medical record review. Using marginal structural model...
Objective. Being overweight or obese increases rheumatoid arthritis (RA) risk among women, particularly those diagnosed at a younger age. Abdominal obesity may contribute to systemic inflammation more than general obesity; thus, we investigated whether abdominal obesity, compared predicted RA in 2 prospective cohorts: the Nurses’ Health Study (NHS) and NHS II. Methods. We followed 50,682 women (1986–2014) 47,597 (1993–2015) II, without baseline. Waist circumference (WC), BMI, health...
Abstract Objective To examine the association of long-term weight change with RA risk in a large prospective cohort study. Methods The Nurses’ Health Study II started 1989 (baseline); after exclusions, we studied 108 505 women 25–42 years old without RA. Incident was reported by participants and confirmed medical record review. Body biennially through 2015. We investigated two time-varying exposures: changes from baseline age 18; divided into five categories. used marginal structural model...
This study was undertaken to examine the relationship between alcohol consumption and hip osteoarthritis in women. Alcohol has been associated with both adverse beneficial health effects generally; however, minimally studied.
Concern over loss of cognitive function, including descent into Alzheimer's disease or dementia, grips a growing percentage men and women worldwide as the global population ages. Many studies, though not all, suggest that maintaining health, well slowing even preventing decline, disease, can be achieved by consuming healthy diets long enough period time. This appears to case for those who initiated dietary changes later in life, evidenced an intervention study assessing consumption diet...
The Mediterranean and Dash Diets, initially associated with better cardiovascular health, have also been improved cognition in older adults. Drawing from both diets, Morris et al. developed the MIND Diet, which focuses on neuroprotective dietary factors has reduced risk of incident Alzheimer's Disease a community sample. To replicate this finding we evaluated associations between diet dementia Women's Health Initiative Memory Study (WHIMS), nationwide cohort women who followed for up to 20...
Figure S1. Validation of the overexpression ETV4 and MMP13 in MCF10A cells. a b Relative mRNA (a) (b) expression MCF10A-Ctrl MCF10A-ETV4 cells determined by real-time PCR normalized to cyclophilin A levels. was arbitrarily = 1. Error bars indicate SD. *P ≤ 0.1. c d Western blot analysis protein (61 kDa) (c) (60 (d) GAPDH served as loading control. (PDF 100 kb)
Nutrient/food-based dietary patterns with pro-inflammatory potential have been associated higher risk of dementia. However, food-group-based may better inform recommendations. We examined associations the empirical inflammatory pattern (EDIP), a index derived to reflect diet, cognitive function and incident mild impairment (MCI) probable included 7,235 postmenopausal women (87.4% Non-Hispanic White, Baseline mean age: 70.1±3.9 years) who were recruited between 1993–1998 in Women's Health...