A5040052490- Mental Health Research Topics
- Schizophrenia research and treatment
- Gut microbiota and health
- Cancer survivorship and care
- Cervical Cancer and HPV Research
- Tendon Structure and Treatment
- Reproductive tract infections research
- Endometrial and Cervical Cancer Treatments
- Functional Brain Connectivity Studies
- Mental Health and Psychiatry
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Myofascial pain diagnosis and treatment
- Digital Mental Health Interventions
- Cancer Risks and Factors
- Advanced Neuroimaging Techniques and Applications
- Architecture and Computational Design
- Criminal Justice and Corrections Analysis
- Veterinary Equine Medical Research
- Music Therapy and Health
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
Orygen
2023-2025
The University of Melbourne
2023-2025
Orygen Youth Health
2023-2025
Emory University
2023
University of Oxford
2022-2023
Grady Memorial Hospital
2020-2022
Emory Healthcare
2021
Monash University
2018
Manx National Heritage
2014
University of Bath
2014
The concept of ultra‐high risk for psychosis (UHR) has been at the forefront psychiatric research several decades, with ultimate goal preventing onset psychotic disorder in high‐risk individuals. Orygen (Melbourne, Australia) led a range observational and intervention studies this clinical population. These datasets have now integrated into UHR 1000+ cohort, consisting sample 1,245 individuals follow‐up period ranging from 1 to 16.7 years. This paper describes presents prediction model...
Youth mental health services are characterised by high demand and modest clinical outcomes. While digital interventions (DMHIs) have been shown to be clinically effective, the relationship between DMHI use outcome is unclear. The current study sought identify factors affecting depression anxiety symptom improvement in sub-groups of young people. An observational cohort design included people aged 12-25 years engaging with a (MOST) from October 2020 2023. primary was at 12 weeks on Patient...
Abstract Background To improve early intervention and personalise treatment for individuals on the psychosis continuum, a greater understanding of symptom dynamics is required. We address this by identifying evaluating movement between empirically derived attenuated psychotic symptomatic substates—clusters symptoms that occur within over time. Methods Data came from 90-day daily diary study affective symptoms. The sample included 96 aged 18–35 divided into four subgroups increasing severity...
The performance of psychiatric risk calculators can deteriorate over time due to changes in patient population, referral pathways, and medical advances. Such temporal biases existing models may lead suboptimal decisions when translated into clinical practice. Methods are available correct this bias, yet no research has been conducted investigate their utility psychiatry. We aimed analyse the model updating methods for predicting psychosis onset by one year 784 individuals at ultra high-risk...
Isometric muscle contractions are used in the management of patellar tendinopathy to manage pain and improve function. Little is known about whether long- or short-duration optimal pain. This study examined immediate short-term (4 weeks) effects isometric contraction on tendon pain, adaptation.Repeated measures within groups.Clinical primary care.Participants (n = 16, males) with tendinopathy.Short-duration (24 sets 10 seconds) long-duration (6 40 knee extension loading (85% maximal...
Abstract Background While the importance of commensal microbes in vaginal health is well appreciated, little known about effects gynecological cancer (GynCa) and radiation therapy (RT) on microbiome (VM) postmenopausal women. Methods We studied women with GynCa, pre‐ (N = 65) post‐RT 25) a group healthy controls 67) by sequencing V4 region 16S rRNA gene from swabs compared diversity composition VMs between three groups accounting for potential confounding factors multivariate analysis...
Despite knowledge of qualitative changes that occur on ultrasound in tendinopathy, there is currently no objective and reliable means to quantify the severity or prognosis tendinopathy ultrasound.
This Viewpoint discusses the limitations of clinical prediction models in psychiatric research.
Background. Mental illnesses mostly occur before 25 years of age when early identification and intervention could delay, ameliorate, or prevent lifelong disability. However, several challenges hinder optimal psychiatric care in youth due to the diversity presentations, comorbidities, illness courses, treatment responses. It is increasingly clear that one-size-fits-all approaches will not be effective personalised are needed guide therapeutic pathways for individuals. Following precedents...
Postmenopausal women often suffer from vaginal symptoms associated with atrophic vaginitis. Additionally, gynecologic cancer survivors may live for decades additional, clinically significant, persistent toxicities caused by therapies, including pain, dyspareunia, and sexual dysfunction. The microbiome (VM) has been previously linked related to menopause ( i.e. dryness). Our previous work showed that patients exhibit distinct VM profiles healthy women, low abundance of lactobacilli prevalence...
To evaluate the associations between social determinants of health (SDOH) and psychoneurologic symptom (PNS) clusters in women with gynecologic cancers during cancer treatment.67 who received radiation therapy were assessed at baseline, six to eight weeks after treatment, months treatment oncology clinics Georgia.Fatigue, pain, sleep disturbances, cognitive impairment, depressive symptoms measured determine a PNS cluster score. Associations SDOH scores using mixed-effect models.Larger mean...
Multimodal modeling that combines biological and clinical data shows promise in predicting transition to psychosis individuals who are at ultra-high risk. Individuals known have deficits baseline cognitive function reductions gray matter volume multiple brain regions identified by magnetic resonance imaging.
The purpose of the present investigation was to evaluate immediate effect running a marathon on Achilles tendon anteroposterior thickness.In 25 runners who took part in London marathon, ultrasonography used measure thickness pre- and immediately post-marathon identify any structural abnormalities indicating tendinopathy. Pain recorded using numerical rating scale at baseline post-marathon. Twenty-one participants were included final analysis.Running resulted significant decrease (- 13%, p <...
Abstract Background Almost 40% of individuals at ultra-high risk (UHR) for psychosis experience persistent attenuated psychotic symptoms (APS) yet it is unclear (1) whether they share overlapping clinical and functional outcomes compared to who transition psychosis, (2) when symptom functioning trajectories begin diverge between UHR with different outcomes, (3) non-remission (persistent APS or transition) can be predicted using baseline and/or longitudinal data. Study Design Participants...
Abstract Introduction: Emerging evidence highlights the role of socioeconomic status (SES) in symptom burden related to cancer treatments. However, its underlying biological mechanisms are not fully understood. Thus, present study aimed evaluate associations between patients’ education, as an indicator SES, and gut microbiome with psychoneurological symptoms (PNS) cluster gynecologic patients over time. Methods: Nineteen women cervical endometrial cancers treated radiotherapy or...
Abstract Background: As the prevalence of obesity in women increases US, a better understanding effect on with gynecologic cancer (GynCa) is imperative. However, whether impacts sexual functioning (SF) GynCa patients has been understudied. Limited studies have used body mass index (BMI) as only indicator, which may result misunderstanding SF different compositions. This study aimed to explore role via two measures determining pre-and post-radiotherapy (RT). Methods: In this secondary...