A5112501940- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Natural Products and Biological Research
- Advances in Cucurbitaceae Research
- Natural product bioactivities and synthesis
- Bone Metabolism and Diseases
- Antioxidant Activity and Oxidative Stress
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Nutrition, Health and Food Behavior
- Genomics, phytochemicals, and oxidative stress
- Potato Plant Research
- Bioactive natural compounds
- Pharmacological Effects and Assays
- Ziziphus Jujuba Studies and Applications
- Neurobiology and Insect Physiology Research
- Phytoestrogen effects and research
- Phytochemistry and biological activity of medicinal plants
- Food Chemistry and Fat Analysis
- Bone health and treatments
- Dye analysis and toxicity
- Plant biochemistry and biosynthesis
- Effects and risks of endocrine disrupting chemicals
- Biochemical Analysis and Sensing Techniques
- Ecology and Conservation Studies
Central Research Institute
2025
Kangwon National University
2020-2021
Aster scaber is a wild vegetable cultivated in Korea and known to contain phytochemicals with various biological activities. The potential antioxidant anti-obesity effects of A. their mechanism are yet be reported. We evaluated the total phenolic, flavonoid, proanthocyanidin contents oxygen radical absorbance capacity ethanolic extract (ASE), analyzed major phenolic compounds ASE. Antioxidant activity was measured at chemical level through 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power...
With the increase in bone metabolic diseases owing to aging of global population, interest functional food ingredients for improving health is increasing. This study aimed determine anti-osteoporosis effect Benincasa hispida extract (BHE, HR1901-W) and 2-furoic acid ovariectomy (OVX)-induced osteoporosis female ICR mice. Thirty-five mice underwent OVX or sham operation were randomized into seven groups five animals as follows: normal, sham, OVX, with genistein (10 mg/kg), (20 LBHE (100 HBHE...
The objective of the present study was to develop a concoction natural products that could dramatically improve immune function with minimal possible side effects. Sasa quelpaertensis Nakai and Ficus erecta var. sieboldii are plants native Jeju Island, Korea known be rich in physiologically active substances. We prepared mixture different proportions extraction conditions using two determined their optimum mixing ratio method by assessing function-related biomarkers RAW264.7 macrophages....
The bioactive compounds of Platycodon grandiflorum have been studied with saponin, including platycodin D (PD) and platycoside E (PE), but functional enhancement studies through bioconversion as fermentation are insufficient. In this study, we determined the potential therapeutic effects fermented extracts (FPE) on atopic dermatitis-induced HaCaT cell line NC/Nga mice. Atopic dermatitis was induced by TNF-α (10 ng/mL)/IFN-γ ng/mL) in cells topical application 0.2% 1-chloro-2,4-dinitrobenzene...
Owing to global population aging, instances of bone metabolic diseases have increased. Consequently, interest in natural and functional plant food products for the prevention treatment osteoporosis is also increasing. In this study, we determine potential therapeutic effects Benincasa hispida extract (HR1901-W) on osteoblast osteoclast differentiation. The preventive not previously been reported. We identified analyzed 2-furoic acid, a chemical component HR1901-W. evaluated whether HR1901-W...
In recent years, Brassica juncea has been selected as a special agricultural crop in Jeongseon, Gangwon-do, Korea, and is actively grown there. However, there have no studies on B. cultivated Jeongseon (BJJ). Sinigrin, an index component of cruciferous vegetables, reported to antiobesity effects. this study, we developed method for obtaining BJJ extract with optimized sinigrin content, investigate the properties sinigrin. The optimal extraction conditions were found be 60% ethanol, at 70°C,...
In this study, we investigated and validated a method for the quantitative analysis of ethoxyquin in paprika seasonings sauces, which are frequently consumed South Korea. Using analytical method, were able to confirm presence under optimized high-performance liquid chromatography/photodiode array (HPLC-PDA) chromatography with tandem mass spectrometry conditions. Additionally, antioxidant activity was assessed using American Spice Trade Association values its residual levels seasoning...
Fermentation is a process that improves health functionality by inducing the production and increase of bioactive compounds. In this study, to standardize fermentation for Benincasa hispida, marker compounds are increased or produced during were identified based on UPLC-QTOF-MS/MS. Analysis method verification content analysis conducted using HPLC-PDA. The in as 2-furoic acid, 2,3-dihydroxybenzoic rubinaphthin A comparing their retention times, UV MS spectra, molecular formulas with those...
The incidence of cardiovascular diseases, such as high blood pressure, is increasing worldwide, owing to population aging and irregular lifestyle habits. Previous studies have reported the vasorelaxant effects Prunus yedoensis bark methanol extract. However, various solvent extracts P. their vascular relaxation mechanisms not been sufficiently studied. We prepared using solvents (water, 30% ethanol, 70% ethanol). ethanol extract (PYB-30E) decreased expression cell adhesion molecule-1...
(i) Background: The increasing prevalence of allergic diseases highlights the need for effective treatments. Lonicera caerulea fruit has been recognized its anti-inflammatory, anti-cancer, and neuroprotective effects, but mechanisms underlying anti-allergic properties remain unclear. (ii) Objective: This study aims to evaluate total phenolic, flavonoid, cyanidin-3-glucoside (C3G) contents extract (HR2302-30E) investigate antioxidant activities. (iii) Methods: Using an IgE-stimulated RBL-2H3...
본 연구는 차풀 잎을 70% 에탄올을 이용하여 추출한 후 항산화 성분 측정, 활성 측정과 피부섬유아세포에서의 및 항노화 효과를 측정하였다. 그 결과 잎 추출물에서 높은 수준의 페놀성 화합물을 함유한 것으로 나타났으며 DPPH, ABTS 라디칼 소거능, 환원력, hydrogen peroxide 소거능 NO 등의 in vitro 실험에서 농도 유의적으로 생리활성을 확인하였다. 피부 섬유아세포에서의 실험은 peroxide를 산화적 스트레스를 유도한 상태에서 추출물의 세포 보호효과, 내 효과 효소 단백질 발현을 관찰하였다. 스트레스로 인해 섬유아세포의 생존율이 감소했지만 처리로 손상이 억제되어 증가하는 관찰되었으며, H₂-DCFDA 염색을 통해 활성산소의 생성을 확인한 추출물에 의한 활성산소 저감을 또한 효소적 방어시스템인 SOD2, catalase, GR, GPX1을 측정한 인하여 감소하였지만, 차풀잎 추출물 방어시스템의 발현 정도가 증가하였다. 이에 따라 노화의 지표인...
Fermentation is a process that improves health functionality by inducing the production and increase of bioactive compounds. In this study, to standardize fermentation for Benincasa hispida, marker compounds are increased or produced during were identified based on UPLC-QTOF-MS/MS. Analysis method verification content analysis conducted using HPLC-PDA. The in as 2-furoic acid, 2,3-dihydroxybenzoic rubinaphthin A comparing their retention times, UV MS spectra, molecular formulas with those...
Recently, interest in functional foods that enhance immunity has increased owing to social and environmental changes. In this study, we investigated the immunomodulatory effects of fermented Benincasa hispida extract (FBE) normal BALB/c mice. FBE enhanced nitric oxide (NO) production natural killer (NK) cell activity. addition, perforin 1 granzyme B production, demonstrating CD8+ cytotoxic T CD4+ helper activity was analyzed by measuring Th1 Th2 cell-related cytokines. cells while...