A5004893446- Surgical Simulation and Training
- Spine and Intervertebral Disc Pathology
- Computational Drug Discovery Methods
- Hospital Admissions and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Lymphoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Hip and Femur Fractures
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Diversity and Career in Medicine
- Management of metastatic bone disease
- Vascular Malformations Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Healthcare Operations and Scheduling Optimization
- Receptor Mechanisms and Signaling
- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cervical and Thoracic Myelopathy
- Cancer therapeutics and mechanisms
- Pregnancy-related medical research
- Neurofibromatosis and Schwannoma Cases
- Opioid Use Disorder Treatment
- TGF-β signaling in diseases
Neurological Surgery
2017-2025
Oregon Health & Science University
2022-2025
American Association of Neurological Surgeons
2025
Center for Cancer Research
2009-2023
Mayo Clinic
2012-2017
University of California, San Francisco
2017
Mayo Clinic in Florida
2015
Baptist Medical Center Jacksonville
2015
Cancer Institute (WIA)
2005-2011
National Cancer Institute
2009
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has uncertain. Using state-of-the-art Taqman-based quantitative RT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome six types, established cell lines (grown monolayer, 3D scaffold, or xenograft) and samples, either containing >75% tumor cells microdissected. The MDR was determined priori based on an extensive curation literature...
Decompressive hemicraniectomy is a common emergent surgery for patients with stroke, hemorrhage, or trauma. The typical incision reverse question mark (RQM); however, retroauricular (RA) has been proposed as an alternative. widespread adoption ofthe RA slowed by lack of familiarity and concerns over decompression efficacy. Our goal to compare the vs RQM incisions regarding safety examine skill acquisition among resident neurosurgeons. Six cadaveric heads were randomized first receive either...
INTRODUCTION: Burnout is a critical issue among healthcare providers, particularly in care, necessitating resilience-enhancing programs. Critical care professionals are at heightened risk due to close interaction with severely ill patients, combined lack of continuity patients. To address this, we introduced Vibrancy and Vitality Rounds, aiming counter the challenges Morbidity Mortality sessions by showcasing successful long-term patient outcomes fostering hope, connection, meaning daily...
Study Design: Retrospective cross-sectional study aimed to investigate the postoperative outcomes following anterior cervical discectomy and fusion (ACDF) surgery in patients with end-stage renal disease (ESRD) transplant recipients, using data from a large national database. Three patient groups were analyzed: control group, ESRD group. Objective: To ACDF utilizing Background: Patients recipients face unique health challenges, there is paucity of comprehensive research examining their...
Study Design A retrospective cohort utilizing the PearlDiver Patient Claims Database. Objective Cervical disc arthroplasty (CDA) is accepted treatment for cervical radiculopathy; however, it may also be safe and effective in myelopathy. Thus, we compared clinical characteristics outcomes patients undergoing CDA anterior discectomy fusion (ACDF) degenerative myelopathy (DCM) specifically. Methods Patients or ACDF between 2015-2019 were identified with follow-up through 2021. Univariate...
Abstract The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment cancer. Resistance exists against every effective anticancer drug and can develop by multiple mechanisms. These mechanisms act individually or synergistically, leading MDR, which cell becomes resistant variety structurally mechanistically unrelated drugs addition initially administered. Although extensive work has been done characterize MDR vitro, translation this knowledge...
Wide-necked anterior communicating artery aneurysms represent a subset of lesions with challenging endovascular treatment despite new endoluminal and intrasaccular devices.To assess the long-term clinical angiographic outcomes stent-assisted embolization for wide-necked aneurysms.Between March 2008 2014, 32 patients unruptured AComm were treated using embolization. The Glasgow Outcome Scale was reviewed at time discharge latest follow-up. Ischemic hemorrhagic events also recorded analyzed....
BACKGROUND AND OBJECTIVES: Labeling residents as “black” or “white” clouds based on perceived presumed workloads is a timeworn custom across medical training and practice. Previous studies examining whether such perceptions align with objective workload patterns have offered conflicting results. We assessed peer-assigned labels were associated between-resident differences in objective, on-call metrics three classes of neurosurgery junior residents. In doing so, we introduce more inclusive...
BACKGROUND AND IMPORTANCE: Intracranial dural arteriovenous fistulas (DAVFs) are acquired abnormal communications between arteries and veins. Risk factors for development include sinus thrombosis hypercoagulability, such as occurs in heritable thrombophilias. While there have been reports of other types vascular anomalies (such cavernous malformations) occurring families, to our knowledge no familial intracranial DAVFs. We describe the first 2 cases DAVFs first-degree relatives. CLINICAL...
The study objective was to create a novel milestones evaluation form for neurosurgery sub-interns and assess its potential as quantitative standardized performance assessment compare residency applicants. In this pilot study, the authors aimed determine form's interrater reliability, relationship percentile assignments in letter of recommendation (SLOR), ability quantitatively differentiate tiers students, ease use.
The purpose of this study is to examine the utilization kyphoplasty/vertebroplasty procedures in management compression fractures. With growing elderly population and associated increase rates osteoporosis, vertebral fractures have become a daily encounter for spine surgeons. However, there remains lack consensus on optimal patient population.
To comply with the removal of 88-hour week exemption and to support additional operative experience during junior residency, Oregon Health & Science University (OHSU) switched from a night-float call schedule modified 24-hour on July 1, 2019. This study compared volumes clinical, procedural, cases experienced by postgraduate year 2 (PGY-2) PGY-3 residents under these systems.The authors retrospectively studied billing related clinical records, schedules, Accreditation Council for Graduate...
INTRODUCTION: Cervical arthroplasty is a treatment for cervical radiculopathy; however, it may also be safe and effective in patients with mild myelopathy. METHODS: Retrospective data spanning 2016-2020 from the PearlDiver Patient Claims Database was used to select patients. Age, gender, osteoporosis, obesity, smoking, diabetes, Charlson Comorbidity Index (CCI), 1- or 2-level surgery, re-operation rates, 90-day readmission, medical complications, morphine milligram equivalents (MME)...
Bundled payment for care improvement advanced (BPCIA) is a voluntary alternative model administered by the Centers Medicare and Medicaid Services using value-based to reduce costs incentivizing coordination improved quality. We aimed identify drivers of negative financial performance in BPCIA among patients undergoing spinal fusion surgery.
ABSTRACT Background The proportion of women surgeons is increasing, but studies show that in surgical residency are granted less autonomy than men. Objective We utilized the Surgical Autonomy Program (SAP), an educational framework, to evaluate gender differences self-reported autonomy, attending-reported and operative feedback among US neurosurgical residents. Methods SAP tracks resident progression guides teaching neurosurgery. Surgeries divided into zones proximal development (opening,...
To the Editor: Thank you for opportunity to respond letter by Dr Nguyen et al.1 We appreciate and colleagues' thorough reading of our work in Neurosurgery on workload differences on-call neurosurgery residents.2 Their brief report furthers understanding variability an under-studied area training, which we are so grateful. pleased offer detailed responses: Study Design: al tabulated similar data, focusing consult number, urgent/emergent surgery, bedside procedures, like study. They...
INTRODUCTION: Low-grade gliomas represent 10%-15% of all brain tumors in adults. Increasing data suggest that initial maximal surgical resection at the time diagnosis may lead to improved survival provided morbidity surgery does not significantly impair patient quality life. To further investigate benefits and risks this population, we conducted a retrospective review examining outcomes patients with intracranial low-grade undergoing our institution. METHODS: Adult newly diagnosed craniotomy...
OBJECTIVE Bone morphogenetic protein (BMP) has been increasingly used in spinal surgery to promote arthrodesis. Because BMP stimulates cellular proliferation, its association with tumorigenesis is a concern. Previous research generated conflicting conclusions on the risk of cancer patients receiving BMP. The authors aimed compare incidence solid organ and hematopoietic malignancies undergoing arthrodesis or without METHODS PearlDiver Mariner Patient Claims Database was queried for...