A5063212845- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- S100 Proteins and Annexins
- SARS-CoV-2 detection and testing
- Acute Myeloid Leukemia Research
- Sepsis Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Chronic Lymphocytic Leukemia Research
- Intensive Care Unit Cognitive Disorders
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Response and Inflammation
- Trace Elements in Health
- Bacterial Infections and Vaccines
- Celiac Disease Research and Management
- Long-Term Effects of COVID-19
- Immunodeficiency and Autoimmune Disorders
- Vaccine Coverage and Hesitancy
- Venomous Animal Envenomation and Studies
- Intestinal and Peritoneal Adhesions
- Multiple Myeloma Research and Treatments
- Cardiovascular and Diving-Related Complications
- Food Allergy and Anaphylaxis Research
- Biomedical and Chemical Research
KU Leuven
2021-2025
AZ Sint-Jan
2020-2025
Universitair Ziekenhuis Leuven
2021-2022
Korea Disease Control and Prevention Agency
2022
Korea University
2022
Onze Lieve Vrouwziekenhuis Hospital
2021-2022
AZ Sint-Lucas
2019
This retrospective multi-center matched cohort study assessed the risk for severe COVID-19 (combination of severity indicators), intensive care unit (ICU) admission, and in-hospital mortality in hospitalized patients when infected with Omicron variant compared to Delta variant. The is based on a causal framework using individually-linked data from national registries. population consisted 954 (of which, 445 were Omicron) above 18 years old admitted Belgian hospital during autumn winter...
Calprotectin (CLP) is a promising biomarker for the evaluation of neutrophil-related inflammation. Our aim was to establish reference values circulating CLP in different sample types and study effect pre-analytical variables. Reference were determined 100 healthy individuals. Pre-analytical variables evaluated 10 controls four rheumatoid arthritis patients with active disease covered type (serum with/without gel separator, heparin, EDTA citrate plasma), pre-centrifugation time (<2 h, 6 24...
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the general population context a relatively high immunity gained through early waves disease 19 (COVID-19), and vaccination campaigns. Despite this context, significant number patients were hospitalized, identifying risk factors associated with era is critical for targeting further preventive, curative interventions. We retrospectively analyzed individual medical records 1501 SARS-CoV-2 positive...
Illustrated by a clinical case supplemented epidemiologic data, early reinfections with SARS-CoV-2 Omicron BA.1 after infection Delta variant, and reinfection BA.2 infection, can occur within 60 days, especially in young, unvaccinated persons. The definition of reinfection, which influences retesting policies, should be reconsidered.
Analytical validation of newly released SARS-CoV-2 antibody assays in the clinical laboratory is crucial to ensure sufficient performance respect its intended use. We aimed assess analytical and diagnostic 8 (semi-)quantitative detecting anti-nucleocapsid IgG (Euroimmun, Id-Vet) or total Ig (Roche), anti-spike protein Theradiag, DiaSorin, Thermo Fisher) both (Theradiag) 2 rapid lateral flow (LFA) (AAZ-LMB Theradiag).
Abstract The emergence of the SARS-CoV-2 Omicron variant, characterized by a significant antigenic diversity compared to previous Delta had led decrease in antibody efficacy both convalescent and vaccinees’ sera resulting high number reinfections breakthrough cases worldwide. However, date, are defined ECDC as two positive tests ≥60 days apart, influencing retesting policies after an initial test several European countries. We illustrate clinical case supplemental epidemiological data that...
Circulating calprotectin (cCLP) has been shown to be a promising prognostic marker for COVID-19 severity. We aimed investigate the value of serial measurements cCLP in patients admitted an intensive care unit (ICU).From November 2020 May 2021, with COVID-19, at ICU OLV Hospital, Aalst, Belgium, were prospectively included. For sixty-six (66) patients, blood samples collected admission and subsequently every 48 h during stay. On sample (total n=301), (EliA™ Calprotectin 2, Phadia 200, Thermo...
Serum free light chain (sFLC) measurements have inherent analytical limitations impacting sFLC clinical interpretation. We evaluated and diagnostic performance of three polyclonal assays on four platforms.sFLC concentration was measured using Diazyme FLC (Diazyme) cobas c501/c503 analyzer (Roche); Freelite (The Binding Site) Optilite c501 Sebia ELISA (Sebia) AP22 ELITE (DAS). Imprecision, linearity, method comparison vs. Freelite/Optilite, antigen excess detection reference value...
We present a case of young man with known urinary tract abnormalities who developed pyelonephritis and bacteremia caused by Haemophilus parainfluenzae. Since routine urine culture usually does not include enriched media for spp., the true incidence infections H. parainfluenzae is currently unknown. Our case, however, demonstrates that potential pathogen, at least in patients anomalies. Clinical laboratories should consider expanding their efforts to detect unusual pathogens underlying risk factors.
Abstract Background Barely two per million Belgian children/adolescents are diagnosed with chronic myeloid leukemia (CML) annually. In this retrospective study, we aimed to investigate the diagnostic features, clinical and laboratory characteristics, treatment outcome of rare entity. Methods Medical records all pediatric CML patients (age ≤ 17 years) at University Hospitals Leuven between 1986 2021 were reviewed. Results Fourteen (median age diagnosis 12.5 included, presenting in phase. Five...