A5087972355- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- Silk-based biomaterials and applications
- Polymer Surface Interaction Studies
- Nerve injury and regeneration
- Innovative Microfluidic and Catalytic Techniques Innovation
- biodegradable polymer synthesis and properties
- Biomedical Text Mining and Ontologies
- Polymer Nanocomposite Synthesis and Irradiation
- Bone Tissue Engineering Materials
- Supramolecular Self-Assembly in Materials
- Orthopaedic implants and arthroplasty
- Neuroinflammation and Neurodegeneration Mechanisms
- Additive Manufacturing and 3D Printing Technologies
- Wound Healing and Treatments
- Supercapacitor Materials and Fabrication
- Spinal Cord Injury Research
- Spine and Intervertebral Disc Pathology
- Adsorption and biosorption for pollutant removal
- Cell Image Analysis Techniques
- Advanced Drug Delivery Systems
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Sensor and Energy Harvesting Materials
- Neurogenesis and neuroplasticity mechanisms
Zhejiang University
2025
Duke University
2022
Texas A&M University
2016-2021
Mitchell Institute
2019-2021
College Station Medical Center
2019
Gainesville Obstetrics & Gynecology
2016
University of Florida
2015-2016
Wuhan University
2013-2016
Hubei University of Technology
2016
Huazhong Agricultural University
2012-2013
Clickable poly(ethylene glycol) hydrogel microspheres can be 3D printed and photochemically annealed to produce complex cell-laden structures.
The assembly of microgel building blocks into 3D scaffolds is an emerging strategy for tissue engineering. A key advantage that the inherent microporosity these provides cells with a more permissive environment than conventional nanoporous hydrogels. Here, norbornene-bearing poly(ethylene glycol) (PEG) based microgels are assembled cell-instructive using PEG-dithiol linker and thiol-ene click photopolymerization. bulk modulus materials depends primarily on crosslink density blocks. However,...
Bioprinting hydrogel microparticles requires consideration of size, stiffness, and nozzle geometry due to jamming effects.
Abstract Extracellular vesicle (EV)‐incorporated hydrogels have emerged as promising scaffolds for tissue repair due to their ability present biological cues. However, the encapsulation efficiency and distribution of EVs within still require improvement enhance healing outcomes. In this study, a novel approach is developed that uses crosslinkers hydrogel formation, ensuring are at every crosslinking point thereby achieving both functional incorporation uniform EVs. Amphiphilic molecules with...
Layer-by-layer coating technique is effective in modifying the surface of nanofibrous mats, but overmuch film-coating makes mats less porous to hardly suit condition for tissue engineering. We developed novel layer-by-layer coated by silk fibroin and lysozyme on cellulose electrospun template via electrostatic interaction. The assembled was not excessive because charge proteins varied process due different pH value. In addition, pure nature materials made nontoxic, biodegradable low-cost....
Abstract Microporous annealed particle (MAP) hydrogels are an attractive platform for engineering biomaterials with controlled heterogeneity. Here, a microfluidic method is introduced to create physicochemical gradients within poly(ethylene glycol) based MAP hydrogels. By combining mixing and droplet generator modules, microgels varying properties produced by adjusting the relative flow rates between two precursor solutions collected layer‐by‐layer in syringe. Subsequently, injected out of...
Microporous annealed particle (MAP) hydrogels are an emerging class of biomaterials with the potential to improve outcomes in tissue repair and regeneration. Here, a new MAP hydrogel platform comprising poly(ethylene) glycol (PEG) microparticles that situ using bio-orthogonal tetrazine click chemistry is reported (i.e., TzMAP hydrogels). Briefly, clickable PEG-peptide extracellular matrix mimetic peptides permit cell adhesion enzymatic degradation were fabricated via submerged...
Damaged axons in the adult mammalian central nervous system (CNS), including those of spinal cord, have extremely limited endogenous capacity to regenerate. This is result both intrinsic and extrinsic inhibitory factors that limit regeneration neurons. Despite attempts or eliminate components, neurons CNS still limited. Therefore, additional can further enhance plasticity need be considered. Herein, we examine effects brain-derived neurotrophic factor (BDNF), a known growth for neuronal...
Core-shell structured beads were fabricated from chitosan (CS)/organic rectorite (OREC) composites and alginate (ALG) in Ca(2+) aqueous solutions with different mixing ratios by a cross-linking process. The mechanical properties, surface internal morphology, intercalation structure between CS OREC, porosity pore size distribution, bovine serum albumin (BSA) encapsulation efficiency its controllable release ability investigated. Optical microscopy, scanning electron microscopy transmission...
Instructive biomaterials capable of controlling the behaviour cells are particularly interesting scaffolds for tissue engineering and regenerative medicine. Novel important in societies with rapidly aging populations, where demand organ/tissue donations is greater than their supply. Herein we describe preparation electrically conductive silk film-based nerve that manufactured using all aqueous processing. Aqueous solutions Bombyx mori were cast on flexible polydimethylsiloxane substrates...
This paper reported antibacterial hydroxypropyl chitosan (HPCS)/organic rectorite (OREC)-based nanofibrous mats with intercalated structure fabricated via solution intercalation method and electrospinning. Field emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectra, Energy-dispersive spectroscopy, photoelectron inhibition zone surrounding circular disks measurement were performed to characterize the morphology, structure, elements analysis, properties...
Abstract Reactive astrocytes are both neurotoxic and pro-regenerative. Their reparative roles after injury have been demonstrated, but how they play a contributing role to regeneration remains question. Here, we investigate the use of astrocytic extracellular vesicles from primary cultured in reactive conditions promoting repair ischemic stroke. Our studies show that derived co-express significant number genes (155 upregulated including log2 9.61 for Lcn2 ) axonal outgrowth (59 3.49 Ntn1...
Objective: To observe the degradation process of biodegradable magnesium alloy stent (BMAS) in vivo order to evaluate its time and biological safety. Methods: Twenty-four male New Zealand white rabbits were divided into two groups: group A (n=12) B (n=12). The BMAS (a total 12) was implanted infrarenal aorta each rabbit A, while control group, without treatment. Color Doppler ultrasound used at 1, 2, 3, 4 months postoperatively stents A. arterial blood samples main organs groups also...