A5022973255- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Sleep and Wakefulness Research
- Therapeutic Uses of Natural Elements
- Sleep and Work-Related Fatigue
- Sleep and related disorders
- Influenza Virus Research Studies
- Bacterial biofilms and quorum sensing
- Microbial Inactivation Methods
- Transgenic Plants and Applications
- Nanoparticles: synthesis and applications
- Bacteriophages and microbial interactions
Fudan University
2025
Central Hospital of Putuo District
2025
Huashan Hospital
2025
University of North Carolina at Chapel Hill
2018-2023
The development and progression of colorectal cancer (CRC) is closely related to gut microbiome. Here, the impact lipopolysaccharide (LPS), one most prevalent products in microbiome, on CRC immunotherapy investigated. It found that LPS abundant orthotopic tissue associated with low responses anti-PD-L1 mAb therapy, clearance Gram-negative bacteria from using polymyxin B (PmB) or blockade Toll-like receptor 4 TAK-242 will both relieve immunosuppressive microenvironment boost T-cell...
It has been demonstrated that older adults' cognitive capacities can be improved with sleep duration. However, the relationship between overweight, obesity, and decline remains a subject of debate. The impact duration on performance in seniors body mass index (BMI) ≥ 25 kg/m2 is largely unknown. This makes it an intriguing to explore further. study used data from National Health Nutrition Examination Survey (NHANES) (2011-2014) 2,243 participants. Weighted multivariate linear regression...
Influenza virus is a major cause of death on global scale. Seasonal vaccines have been developed to combat influenza; however, they are not always highly effective. One strategy develop more broadly active influenza vaccine the use multiple rounds layered consensus buildings generate recombinant antigens, termed computationally optimized reactive antigen (COBRA). Immunization with COBRA hemagglutinin (HA) can elicit broad protection against strains single subtype (e.g., H1N1). We formulated...
Microbe-based therapeutics (MBTs) are an emerging therapeutic modality for treating gastrointestinal infections and inflammatory bowel diseases. Current formulations oral delivery of MBTs use capsules to achieve safe gastric transit, but that control the spatiotemporal concentration yet be developed, despite well-established connections between all their location, concentration, distribution at sites action. The development a multi-functional polymer-based encapsulation system formulate...
Live microbes such as lactobacilli have long been used probiotic supplements and, more recently, explored live biotherapeutic products with the potential to treat a range of conditions. Among these is category anaerobes that possess therapeutic while exhibiting unique oxygen sensitivity and thus requiring careful considerations in formulation storage processes. Existing microbial development has focused on facultative natural tolerance; few strategies reported for demonstrated intolerance,...
Abstract Live biotherapeutic products (LBPs) are an emerging therapeutic modality that have been clinically investigated for treating pathogenic infections and inflammatory diseases. A major class of LBPs feces‐derived microbial consortiums which require numerous process development steps (e.g., separation, purification, blending) to facilitate LBP formulation into oral dosage forms. subset these circumvents the need continuous fecal processing by batch culture individual strains microbes...