A5044479012- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Probiotics and Fermented Foods
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Gut microbiota and health
- Erythrocyte Function and Pathophysiology
- Transgenic Plants and Applications
- Blood properties and coagulation
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced biosensing and bioanalysis techniques
- Nanoparticles: synthesis and applications
- Inhalation and Respiratory Drug Delivery
- Dermatology and Skin Diseases
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Cancer Research and Treatments
- Clostridium difficile and Clostridium perfringens research
- Immunotherapy and Immune Responses
- Biomedical and Engineering Education
- Virus-based gene therapy research
University of North Carolina at Chapel Hill
2017-2024
American Pharmacists Association
2011-2021
University of California, Santa Barbara
2013-2020
Massachusetts Institute of Technology
2015-2019
University of California System
2015
Rensselaer Polytechnic Institute
2011
Ospedale Policlinico San Martino
1986
Biosensors based on field-effect transistors (FETs) have attracted much attention, as they offer rapid, inexpensive, and label-free detection. While the low sensitivity of FET biosensors bulk 3D structures has been overcome by using 1D (nanotubes/nanowires), latter face severe fabrication challenges, impairing their practical applications. In this paper, we introduce demonstrate molybdenum disulfide (MoS2), which provides extremely high at same time offers easy patternability device...
Vascular endothelium offers a variety of therapeutic targets for the treatment cancer, cardiovascular diseases, inflammation, and oxidative stress. Significant research has been focused on developing agents to target in diseased tissues. This includes identification antibodies against adhesion molecules neovascular expression markers or peptides discovered using phage display. Such targeting also have used deliver nanoparticles tissue. Here we report, based vitro vivo studies, that...
The impact of physical and chemical modifications nanoparticles on their biological function has been systemically investigated exploited to improve circulation targeting. However, the nanoparticles' flexibility (i.e., elastic modulus) explored a far lesser extent, potential benefits tuning nanoparticle elasticity are not clear. Here, we describe method synthesize polyethylene glycol (PEG)-based hydrogel uniform size (200 nm) with moduli ranging from 0.255 3000 kPa. These particles used...
The gastrointestinal (GI) microbiome is widely investigated for its role in many diseases. However, technologies designed delivery are lacking. Here, a layer-by-layer (LbL) approach reported probiotic encapsulation to protect probiotics against GI tract insults and improve their adhesion growth on the intestines. These advantages translate significantly enhanced survival of LbL-probiotics vivo. As service our authors readers, this journal provides supporting information supplied by authors....
Nanoparticulate drug delivery systems are one of the most widely investigated approaches for developing novel therapies a variety diseases. However, rapid clearance and poor targeting limit their clinical utility. Here, we describe an approach to harness flexibility, circulation, vascular mobility red blood cells (RBCs) simultaneously overcome these limitations (cellular hitchhiking). A noncovalent attachment nanoparticles RBCs increases level in over 24 h period allows transient...
Targeted delivery of therapeutic and imaging agents in the vascular compartment represents a significant hurdle using nanomedicine for treating hemorrhage, thrombosis, atherosclerosis. While several types nanoparticles have been developed to meet this goal, their utility is limited by poor circulation, margination, minimal targeting. Platelets an innate ability marginate wall specifically interact with injury sites. These platelet functions are mediated shape, flexibility, complex surface...
Technology used for computer chip manufacturing is combined with soft lithography to produce small polymeric structures.
Abstract Probiotic and engineered microbe-based therapeutics are an emerging class of pharmaceutical agents. They represent a promising strategy for treating various chronic inflammatory conditions by interacting with the host immune system and/or delivering therapeutic molecules. Here, we targeted probiotic yeast platform wherein Saccharomyces boulardii is designed to bind abundant extracellular matrix proteins found within lesions gastrointestinal tract through tunable antibody surface...