A5052257730- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Genomics, phytochemicals, and oxidative stress
- Natural Antidiabetic Agents Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Radiopharmaceutical Chemistry and Applications
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Bioactive Compounds and Antitumor Agents
- Galectins and Cancer Biology
- Phytochemistry Medicinal Plant Applications
- Nutrition, Genetics, and Disease
- Wound Healing and Treatments
- Endometrial and Cervical Cancer Treatments
- Tendon Structure and Treatment
- Macrophage Migration Inhibitory Factor
- Phytochemicals and Antioxidant Activities
- Advanced biosensing and bioanalysis techniques
- Natural product bioactivities and synthesis
- Tannin, Tannase and Anticancer Activities
- Bee Products Chemical Analysis
- Cancer-related cognitive impairment studies
Universidade Federal do Rio de Janeiro
2018-2023
Universidade do Estado do Rio de Janeiro
2023
Universidade Estadual da Zona Oeste
2015-2020
Escola Nacional de Saúde Pública
2015-2016
Fundação Oswaldo Cruz
2015-2016
Dermal wound healing involves a cascade of complex events including angiogenesis and extracellular matrix remodeling. Several groups have focused in the study skin activity natural products. The phytomedicine Acheflan®, its main active constituent is oil from Cordia verbenacea which has known anti-inflammatory, analgesic antimicrobial activities. To our knowledge, no investigation evaluated effect Acheflan® an experimental model healing. present explored property compared it with topical...
Among the processes involved in breast tumor microenvironment, angiogenesis and inflammation play a central role, main factors of these are vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2) macrophages. Recently, extract Euterpe oleracea (açaí), fruit that is widely found Amazon region, already showed antitumorigenic effects vitro human cancer cell lines. The present study aimed to investigate effect açaí on using chemically DMBA (7,12-dimethylbenzanthracene) experimental...
This study investigated the therapeutic potential of Euterpe oleracea extract (açaí) on growth and survival endometriotic lesions using an experimental model. Twenty female Sprague-Dawley rats were randomized into two groups after implantation establishment autologous endometrium onto peritoneum abdominal wall treated with 200 mg/kg hydroalcoholic solution from açaí stone or vehicle via gastric tube for 30 consecutive days. Body weight, lesion surface areas, histological immunohistochemistry...
The use of monoclonal antibodies and aptamers is growing every single day, as the nanoparticle systems. Although most products are under investigation, there a few commercialized available at market, for human consume. In this study, we have compared three formulations (aptamer anti-MUC1, antibody – Trastuzumab nanoparticles PLA/PVA/MMT trastuzumab) to identify their profile also understand behavior into an alive biological system. direction radiolabeling were done they all tested in animals...
This study aimed to analyse the effects of clotrimazole (CTZ) on estrogen production pathway in endometriosis progression. Experimental was induced by autologous transplantation female Wistar rats, and then rats were treated with (200 mg/kg) or vehicle, both orally intraperitoneally, for 15 consecutive days. Serum levels vaginal smear analyses performed ERα (estrogen receptor alpha) CYP19 (cytochrome P450 aromatase) endometriotic lesions analysed morphologically immunohistochemically. The...
Abstract Background Açaí, a Brazilian native fruit, has already been demonstrated to play role in the progress of breast cancer and cardiotoxicity promoted by chemotherapy agents. Thus, present study aimed evaluate combined use açaí FAC-D protocol model vivo. Methods Mammary carcinogenesis was induced thirty female Wistar rats subcutaneous injection 25 mg/kg 7,12-dimethylbenzanthracene (DMBA) mammary gland. After sixty days, were randomized into two groups: treated with 200 either extract or...