Abstract One of the major challenges on way to low‐cost, simple, and effective cancer treatments is lack smart anticancer drug delivery materials with requisite site‐specific microenvironment‐responsive properties. This work reports development plasma‐engineered nanocarriers (SDNCs) containing chitosan nitrogen‐doped graphene quantum dots (NGQDs) for in a pH‐responsive manner. Through customized microplasma processing, highly cross‐linked SDNC only 4.5% NGQD ratio can exhibit enhanced...

Osteoarthritis is a widespread and debilitating condition, particularly affecting the medial compartment of knee joint due to varus deformities. Medial opening wedge high tibial osteotomy (MOWHTO) has emerged as an effective treatment, but it comes with challenges like fractures, correction loss, nonunion, leading unsatisfactory results in up 26 % patients. In response, our study explores potential bioabsorbable magnesium-based bulk metallic glass composite (Mg67Zn28Ca5 BMGC) enriched...

The introduction and designing of functional thermoresponsive hydrogels have been recommended as recent potential therapeutic approaches for biomedical applications. development bioactive materials such thermosensitive gelatin-incorporated nano-organic with a porous structure photothermally triggerable cell adhesion properties may potentially achieve this goal. This novel class photothermal can provide an advantage hyperthermia together reversibly transformable hydrogel tissue engineering....

Bioactive and mechanically stable metal-based scaffolds are commonly used for bone defect repair. However, conventional induce nonuniform cell growth, limiting damaged tissue restoration. Here, we develop a plasma nanotechnology-enhanced graphene quantum dot (GQD) hydrogel-magnesium (Mg) composite scaffold functional repair by integrating bioresource-derived nitrogen-doped GQD (NGQD) hydrogel into the Mg ZK60 alloy. Each component brings major synergistic advantages over current alloy-based...

3D Bioscaffold with relative high mechanical property was developed using rabbit ADSCs.

The nonunion and delayed union of bones are common challenges in orthopedic surgery, even when bone alignment is correct sufficient mechanical stability provided. To address this, artificial grafts often applied to fracture gaps or defect sites promote osteogenesis enhance healing. In this study, we developed an alginate-based hydrogel incorporating gold nanoparticles (AuNPs) cell proliferation facilitate healing through a photothermal effect induced by near-infrared (NIR) laser irradiation....

Mg-based alloys have great potential for development into fixation implants because of their highly biocompatible and biodegradable metallic properties. In this study, we sought to determine the biocompatibility Mg60Zn35Ca5 bulk glass composite (BMGC) with fabricated in a rabbit tendon-bone interference model. We investigated cellular cytotoxicity BMGC toward osteoblasts compared it conventional titanium alloy (Ti6Al4V) polylactic acid (PLA). The results show that may be classed as slightly...

Large bone defects in the distal femur present a significant challenge due to lack of inherent self-healing capabilities. Traditional approaches, such as utilizing polymethyl methacrylate (PMMA) conjunction with plate for reconstruction, have shown unsatisfactory osseointegration outcome, which leads complications. To address this challenge, study focuses on developing lattice-structured implant reconstructing femoral defects. The lattice geometry is based cuboctahedron lattice, its design...

Mg-based bulk metallic glass materials have been investigated for their large potential application in orthopedic implants due to biocompatibility, low degradation rate, and osteogenetic ability. As an implant, initial cell adhesion has a critical issue subsequent osteogenesis bone formation because the first contact between cells implant occurs upon surface. Here, we aimed create samples with three different surface roughness attributes order understand behavior of ability cells. It was...

Background and Purpose: Strontium ranelate (SrR) is an oral pharmaceutical agent for osteoporosis. In recent years, numerous unwanted side effects of SrR have been revealed. Therefore, its clinical administration applications are limited. Hereby, this study aims to develop, formulate, characterize effective carrier system spinal bone regeneration. Methods: Herein, glycol chitosan with hyaluronic acid (HA)-based nanoformulation was used encapsulate nanoparticles (SrRNPs) through electrostatic...

Mg-Zn-Ca bulk metallic glass (BMG) is a promising orthopedic fixation implant because of its biodegradable and biocompatible properties. Structural supporting bone implants with osteoinduction properties for effective regeneration have been highly desired in recent years. Osteogenic growth peptide (OGP) can increase the proliferation differentiation mesenchymal stem cells enhance mineralization osteoblast cells. However, short half-life non-specificity to target areas limit applications OGP....

Platelet-rich fibrin (PRF) is a natural meshwork material with multiple functions that are suitable for tissue engineering applications. PRF provides scaffold critical-size bone defect treatment due to its platelet cytokines and rich growth factors. However, the structure of not only promotes cell attachment but also, density, pool migration into facilitate regeneration. In our study, we used repeated freeze drying enlarge pores engineer large-pore (LPPRF), type has expanded migration....

Platelet-rich fibrin (PRF) and Photobiomodulation (PBM) are established methods for promoting bone healing. PRF enhances cell proliferation migration due to its rich concentration of growth factors, while PBM stimulates tissue repair through mitochondrial activation. Despite their efficacies, no in-depth studies have explored the synergistic effects combining PBM.

In this study, a porous titanium zirconium (TiZr)-based bulk metallic foam was successfully fabricated using the Cu spacer by employing hot press method. TiZr-based foams with porosities ranging from 0% to 50% were and analyzed. The results indicate that thermal conductivity increased addition of spacer; reduced holding time in Moreover, compressive strength decreased 1261 76 MPa when porosity 50%, predictable. addition, demonstrated favorable biocompatibility cell viability, migration...

Smart Anticancer Drug Nanocarriers In article number 2206813, Neralla Vijayakameswara Rao, Wei-Hung Chiang, and co-workers develop a plasma engineering of nitrogen-doped graphene quantum dot (NGQD) hydrogels with robust, porous photoluminescence properties. The presence NGQDs in the hydrogel can accelerate improve loading capacity anticancer drug doxorubicin via π-π interaction, exhibits stable solid-state photo-luminescence (PL) to monitor releasing through Förster resonance energy transfer...

More and more elderly problems come to our life the health care become important. Elderly people with lower extremities weakness usually use walkers assist in walking. Although commercial standard (N-type) can improve people's walking ability, users sometimes take risk of falling when using perform sit-to-stand (STS). The purpose this study is design an additional armrest which be attached a walker for performing STS easily evaluate it clinical assessments body worn sensor.The combination...