Riley S. Carter
A5056272622- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- Biochemical and Structural Characterization
- Plant biochemistry and biosynthesis
- Microbial Metabolism and Applications
- Ubiquitin and proteasome pathways
- Microbial Natural Products and Biosynthesis
- Chemical Synthesis and Analysis
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
University of Illinois Urbana-Champaign
2024
Abstract Specialized or secondary metabolites are small molecules of biological origin, often showing potent activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis these natural products is governed by sets co-regulated physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs a standardized machine-readable way, Minimum Information Biosynthetic Gene cluster (MIBiG) data standard repository was initiated...
Borosins are ribosomally synthesized and post-translationally modified peptides (RiPPs) containing backbone α-N-methylations. These modifications confer favorable pharmacokinetic properties including increased membrane permeability resistance to proteolytic degradation. Previous studies have biochemically bioinformatically explored several borosins, revealing (1) numerous domain architectures (2) diverse core regions lacking conserved sequence elements. Due these characteristics, large-scale...
Cell cycle-regulated gene expression is essential for normal cell growth and development loss of stringent control associated with the acquisition transformed phenotype. The selective synthesis histone proteins during S phase cycle required to render cells competent ordered packaging replicating DNA into chromatin. Regulation H4 transcription requires proliferation-specific promoter binding factor HiNF-D. In diploid cells, HiNF-D activity regulated cycle; nuclear protein extracts prepared...
Borosins are ribosomally synthesized and post-translationally modified peptides containing backbone α-N-methylations. Identification of borosin precursor is difficult because (1) there no conserved sequence elements among (2) the biosynthetic gene clusters contain numerous domain architectures peptide fusions. To tackle this problem, we updated genome mining tool RODEO to automatically evaluate putative BGCs identify peptides. Enabled by new module, analyzed all found in available data...