A5101284199- Angiogenesis and VEGF in Cancer
- Transcranial Magnetic Stimulation Studies
- Neural and Behavioral Psychology Studies
- Cerebrovascular and Carotid Artery Diseases
- Apelin-related biomedical research
- Neurological Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Healthcare Decision-Making and Restraints
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Ginkgo biloba and Cashew Applications
- Mitochondrial Function and Pathology
- Lipid metabolism and disorders
- Nanofabrication and Lithography Techniques
- Dyeing and Modifying Textile Fibers
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Lymphatic System and Diseases
- Pigment Synthesis and Properties
- Autophagy in Disease and Therapy
- Schizophrenia research and treatment
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
Sunnybrook Health Science Centre
2021-2025
University of Toronto
2021-2025
Sunnybrook Research Institute
2021-2025
Sunnybrook Hospital
2021-2024
Health Sciences Centre
2022
Canada Research Chairs
2021
Hebei University of Technology
2014
Angiogenesis may play an important role in the pathophysiology of Alzheimer's disease (AD). Previous vitro and vivo studies suggest a link between angiogenesis cerebral blood flow (CBF) AD; however, this has never been studied clinically. In sample study participants with early AD (n = 15), serum vascular endothelial growth factor (VEGF), biomarker, was negatively associated regional CBF (rCBF) angular gyrus even after bootstrapping at repetition 5000 controlling for age, sex, diagnosis (β...
Abstract Background Transcranial direct current stimulation (tDCS) is a non-invasive type of brain that uses electrical currents to modulate neuronal activity. A small number studies have investigated the effects tDCS on cognition in patients with Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD), demonstrated variable effects. Emerging evidence suggests most effective when applied active circuits. Aerobic exercise known increase cortical excitability improve network connectivity....
Abstract Background Angiopoietin‐2, which regulates endothelial permeability and angiogenesis functions, is emerging as a potential biomarker for early Alzheimer’s disease (AD). Elevated levels of cerebrospinal fluid angiopoietin‐2 concentrations have been found in AD may be associated with the breakdown blood‐brain barrier that can contribute to cognitive decline. There lack research on blood cognition AD. Hence, we examined association between serum global cognition. Method Participants...
Abstract Background Circulating cell‐free mitochondrial DNA (ccf‐mtDNA), a measure of dysfunction, is emerging as potential biomarker for early Alzheimer’s disease (AD). Decreased levels cerebrospinal fluid ccf‐mtDNA concentrations have been detected in AD patients. Few studies investigated peripheral or with cognitive measures, much less evaluating the role physical activity within relationships. Considering hallmark episodic memory impairment AD, we examined association between serum and...
Abstract Background Endostatin is an endogenous angiogenesis inhibitor that can regulate pro‐and anti‐angiogenic factors, notably vascular endothelial growth factor. Research shows endostatin levels in the brain are associated with amyloid plaque formation Alzheimer’s disease (AD), and may contribute to AD pathogenesis. Hence, be relevant broad range of cognitive impairments, namely people mild impairment (MCI), AD, and/or coronary artery (CAD) who at risk for impairment. We examine...
Abstract Background VEGF has been associated with memory decline in neurodegenerative diseases. As an angiogenesis biomarker, should be analyzed to better understand the variable treatment response from tDCS, a non‐invasive brain stimulation, and priming effect of exercise on tDCS for improvements MCI AD. Using blinded data ongoing clinical trial (EXPRESS), we aimed evaluate ability serum predict recall mild AD patients. Method Participants were enrolled five‐week, randomized, receive either...
Oxidizing agent of ferric nitrate was added into Sodium thiosulfate chemical coloring liquid. The influence components concentration and process parameters on the film analysed. results indicated that colored mainly composed CuS, obtained by method combining oxidation sulfidation, it had a better adhesion with substrate, best optimal condition were temperature 70°C 9.5g/L 45g/L respectively.
Abstract Background Studies investigating the use of transcranial direct current stimulation (tDCS) to improve outcomes in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) have reported mixed findings. Such variability may be explained by inter‐individual differences such as demographics or pathology. Given increased prevalence cardiovascular risk factors aging potential changes neurobiology those exhibiting additional vascular etiology, we evaluate influence...
Abstract Background Brain derived neurotrophic factor (BDNF) has been associated with cognitive decline in Alzheimer’s disease (AD) and mild impairment (MCI). Transcranial direct current stimulation (tDCS), a non‐invasive brain stimulation, found to improve functions AD/MCI, particularly after priming. While the mechanism of tDCS response remains unclear, BDNF proposed be involved beneficial effects tDCS. However, few studies have investigated relationship between cognition individuals...