A5100361694- Liver physiology and pathology
- Genetic and Kidney Cyst Diseases
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Liver Disease Diagnosis and Treatment
Anhui Medical University
2020
Ministry of Education of the People's Republic of China
2020
Abstract As an outcome of chronic liver disease, fibrosis involves the activation hepatic stellate cells (HSCs) caused by a variety injuries. It is important to explore approaches inhibit and proliferation HSCs for treatment fibrosis. PLK1 overexpressed in many human tumour has become popular drug target therapy. Therefore, further study function cell cycle valid. In present study, we found that expression was elevated primary isolated from CCl 4 ‐induced mice LX‐2 stimulated with TGF‐β1....
Background: Recurring liver injury leads to inflammation and fibrosis, triggering serious diseases such as cirrhosis. Hepatic stellate cell (HSC) activation proliferation are key processes during fibrogenesis. JunB proto-oncogene (JunB), an AP-1 component, is involved in acute inflammation. However, its fundamental cellular molecular mechanisms fibrosis remain unclear.Methods: Immunohistochemical, western blot RT-qPCR assays were used evaluate expression human mouse fibrotic tissues....