A5070362938- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Orthopedic Infections and Treatments
- Connective tissue disorders research
- High Altitude and Hypoxia
- Shoulder Injury and Treatment
- Cellular Mechanics and Interactions
- Elbow and Forearm Trauma Treatment
- Bone fractures and treatments
- Travel-related health issues
- Protease and Inhibitor Mechanisms
- Neuroscience of respiration and sleep
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular and Diving-Related Complications
- Musculoskeletal synovial abnormalities and treatments
- Peripheral Nerve Disorders
- Radiology practices and education
- Advanced X-ray and CT Imaging
- Collagen: Extraction and Characterization
- Occupational exposure and asthma
- Child Abuse and Related Trauma
- COVID-19 and healthcare impacts
Northumbria Healthcare NHS Foundation Trust
2023-2024
Newcastle University
2015-2023
Wansbeck General Hospital
2023
Princess Elizabeth Orthopaedic Centre
2023
The Honourable Society of Lincoln's Inn
2020-2021
Freeman Hospital
2015-2020
British Society for Surgery of the Hand
2020
Newcastle upon Tyne Hospitals NHS Foundation Trust
2018-2020
Royal Victoria Infirmary
2015-2020
Chapel Allerton Hospital
2020
Embryonic growth occurs predominately by an increase in cell number; little is known about mechanisms later development when fibrous tissues account for the bulk of adult vertebrate mass. We present a model tissue based on 3D-electron microscopy mouse tendon. show that number collagen fibrils increases during embryonic and then remains constant postnatal growth. was explained fibril length. Postnatal arose from length diameter. A helical crimp structure established embryogenesis, persisted...
Aims The aim of this consensus was to develop a definition post-operative fibrosis the knee. Patients and Methods An international panel experts took part in formal process composed discussion phase three Delphi rounds. Results Post-operative knee defined as limited range movement (ROM) flexion and/or extension, that is not attributable an osseous or prosthetic block from malaligned, malpositioned incorrectly sized components, metal hardware, ligament reconstruction, infection (septic...
Collagen fibrils can exceed thousands of microns in length and are therefore the longest, largest, most size-pleomorphic protein polymers vertebrates; thus, knowing how cells transport collagen is essential for a more complete understanding its role tissue morphogenesis. Here, we identified newly formed being transported at surface embryonic tendon vivo by using serial block face-scanning electron microscopy cell-matrix interface. Newly ranged from ~1 to ~30 µm. The shortest (1-10 µm)...
Tendons are composed of longitudinally aligned collagen fibrils arranged in bundles with an undulating pattern, called crimp. The crimp structure is established during embryonic development and plays a vital role the mechanical behaviour tendon, acting as shock-absorber loading. However, mechanism formation unknown, partly because difficulties studying tendon vivo. Here, we used 3D cell culture system which fibroblasts synthesise tendon-like construct comprised parallel bundles....
Abstract A distinctive feature of embryonic tendon development is the steady increase in collagen fibril diameter and associated improvement tissue mechanical properties. potential stimulus for these changes slow stretching during limb growth. Testing this hypothesis vivo complicated by presence other developmental processes including muscle innervation. Here we used a cell culture tendon‐like construct to determine if stretch can explain increases properties that are observed vivo....
The James Lind Alliance aims to bring patients, carers, and clinicians together identify uncertainties regarding care. A Priority Setting Partnership was established by the British Association for Surgery of Knee in conjunction with research priorities related assessment, management, rehabilitation patients persistent symptoms after knee arthroplasty.The project conducted using protocol. steering group convened including surgeons, anaesthetists, nurses, physiotherapists, researchers. Partner...
Tendons attach muscles to bone and thereby transmit tensile forces during joint movement. However, a detailed understanding of the mechanisms that establish mechanical properties tendon has remained elusive because practical difficulties studying tissue mechanics in vivo. Here we have performed study tendon-like constructs made by culturing embryonic cells fixed-length fibrin gels. The display (toe-linear-fail stress-strain curve, stiffness, ultimate strength, failure strain) as well...
Type I collagen-containing fibrils are major structural components of the extracellular matrix vertebrate tissues, especially tendon, but how they formed is not fully understood. MMP14 a potent pericellular collagenase that can cleave type collagen in vitro. In this study, we show tendon development arrested Scleraxis-Cre::Mmp14 lox/lox mice unable to release from plasma membrane fibripositors. contrast its role turnover adult tissue, promotes embryonic tissue formation by releasing cell...
The extensor carpi ulnaris musculotendinous unit has important agonist and antagonist action in wrist motion, including the dart-throwing action, is a dynamic stabilizer of distal radioulnar joint during forearm rotation. Despite its functional clinical importance, little known about internal structure. Investigation ultrastructure human (ECU) tendon was undertaken using plane polarized light microscopy microcomputer tomography with 3D reconstruction. study demonstrates that comprises fibre...
Abstract Arthrofibrosis is a fibroproliferative disease characterised by excessive deposition of extracellular matrix components intra-articularly leading to pain and restricted range movement. Although frequently observed following total knee arthroplasty (TKA) no therapeutic options exist. A pilot study demonstrated that intra-articular injection Anakinra, an IL-1R antagonist, improved movement in patients with arthrofibrosis however the mechanism action unknown. We hypothesise IL-1α/β...
Gastrointestinal symptoms are common on acute exposure to high-altitude (HA). Underlying mechanisms not understood, but vascular shunting away from the gut could be responsible. Therefore, blood flow in superior mesenteric artery (SMA) and hepatic portal vein (HPV) was examined at sea level (SL) after ascent 4392 m (HA).Twelve subjects [eight male, mean age 40 (22-72) years] were studied following an overnight fast a standard meal. Cross-sectional vessel area velocity measured by ultrasound,...
Significance Cells in developing tissues tune the mechanical properties of their extracellular matrix face changes external loading to maintain a tension “set point,” but mechanism has not been studied. We show here that set point is an equilibrium between cell-independent stress relaxation and nonmuscle myosin II-dependent contraction cell. The matrix-dependent cell-dependent phases exhibit oscillating component. Detensioning, also retensioning, induces synchronization oscillations...
ABSTRACT Chronic pain and restricted knee motion is a significant problem following the total arthroplasty (TKA). The molecular pathogenesis of post‐TKA not known no targeted therapeutic intervention available. aim this study was to investigate whether pro‐inflammatory mediators are elevated in revision patients, indicating an active, ongoing inflammatory process that may contribute pain. Twelve key markers (pro‐inflammatory cytokines granulocyte‐macrophage colony‐stimulating factor...
Post-radiation peripheral neuropathy has been reported in brachial and cervical plexuses the femoral nerve. We describe a patient who developed post-radiation sciatic after approximately 3 years discuss pathophysiology, clinical course treatment options available for deleterious effects of radiation to nerves. This is first case involvement nerve literature.
Objective Joint stiffness is a common, debilitating, age-related symptom, which may be seen after total joint replacement (TJR). Stiffness also occurs in fibrotic conditions such as shoulder capsulitis and Dupuytren's contracture. We speculated that the two traits (TJR disease) are linked pathogenically. Methods Using TwinsUK NIHR BRC BioResource we tested hypotheses 1) (hip knee) stiffness, TJR knee), associated 2) genetic factors contribute to them. Results Participating twins (n = 9718)...
The rate of day-case total knee arthroplasty (TKA) in the UK is currently approximately 0.5%. Reducing length stay allows orthopaedic providers to improve efficiency, increase operative throughput, and tackle rising demand for joint surgery COVID-19-related backlog. Here, we report safe delivery TKA an NHS trust via inpatient wards with no additional resources.Day-case TKAs, defined as patients discharged on same calendar day surgery, were retrospectively reviewed a minimum follow-up six...
Pain and knee stiffness are common problems following total replacement surgery, with 10-20% of patients reporting dissatisfaction their procedure. A remote assessment could improve outcomes through continuous monitoring, facilitating timely intervention. Using machine learning algorithms, computer vision can extract joint angles from video footage, offering a method to monitor range motion in patients' homes. This study outlines protocol provide proof concept validate vision-based approach...