A5024435031- HIV-related health complications and treatments
- HIV Research and Treatment
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Vitamin D Research Studies
- Spine and Intervertebral Disc Pathology
- Pain Mechanisms and Treatments
- Titanium Alloys Microstructure and Properties
- Pharmacological Effects and Toxicity Studies
- Medical and Biological Sciences
- Shoulder Injury and Treatment
- HIV/AIDS drug development and treatment
- Bone Tissue Engineering Materials
- Adenosine and Purinergic Signaling
- Mindfulness and Compassion Interventions
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Orthopaedic implants and arthroplasty
- Mental Health Research Topics
Hospital Universitario Fundación Jiménez Díaz
2018-2023
Universidad Autónoma de Madrid
2018-2021
Hospital El Escorial
2019
ABSTRACT Osteopenia and fragility fractures have been associated with human immunodeficiency virus (HIV) infection. Tenofovir, a common antiviral in HIV treatment, also leads to increases bone catabolism markers decreased BMD children young adults. In murine models cell lines, tenofovir inhibits adenosine triphosphate release decreases extracellular levels. Adenosine A2A receptor inhibit osteoclast formation, increase local concentration dipyridamole, an agent that blocks cellular uptake...
Abstract Psychological stress, social isolation, physical inactivity, and reduced access to care during lockdowns throughout a pandemic negatively impact pain function. In the context of first COVID-19 lockdown in Spain, we aimed investigate how different biopsychosocial factors influence chiropractic patients’ pain-related outcomes vice-versa. A total 648 patients completed online questionnaires including variables from following categories: demographics, outcomes, beliefs, pandemic,...
Low back pain is the leading cause of years lived with disability worldwide. Chiropractors employ different interventions to treat low pain, including spinal manipulative therapy, although mechanisms through which chiropractic care improves are still unclear. Clinical research and animal models suggest that manipulation might modulate plasma levels inflammatory cytokines, have been involved in stages pain. More specifically, serum Tumor Necrosis Factor-alpha (TNF-α) found be elevated...
Joint prosthesis failure is mainly related to aseptic loosening and prosthetic joint infections, both of which are associated with high morbidity substantial costs for patients health systems. The development a biomaterial that capable stimulating bone growth while minimizing bacterial adhesion would reduce the incidence failure. We report antibacterial osteostimulatory effects in novel fluorine-phosphorus (F-P)-doped TiO2 oxide film grown on Ti-6Al-4V alloy nanostructure bottle-shaped...
Abstract Background Low BMD (bone mineral density) has been described as a non–AIDS (Acquired Immune Deficiency Syndrome)-related event in HIV (human immunodeficiency virus)-patients but it is poorly studied young HIV-infected men who have received no previous antiretroviral therapy. Methods A cross-sectional study of 245 naïve-HIV-infected over 21 and under 50 years old voluntary attended the Infectious Disease Division appointment Hospital Fundación Jimenez Díaz Madrid, from January 1st,...
Introduction Over two thirds of individuals with low back pain (LBP) may experience recurrent or persistent symptoms in the long term. Yet, current data do not allow to predict who will develop chronic and recover from an acute episode. Elevated serum levels proinflammatory cytokine tumor necrosis factor-α (TNF-α) have been associated poor recovery following episode LBP. Inflammatory cytokines also mediate mechanisms involved nociplastic pain, thus, significant implications primary (CPLBP)....
Plasma levels of adenosine deaminase (ADA), an enzyme that deaminates to inosine, are increased during inflammation. An increase in ADA activity occurs with lower human immunodeficiency virus (HIV) viral load and higher CD4+ T cell counts. We aimed investigate the role plasma as a biomarker inflammation treatment-naïve HIV patients who received tenofovir or another nucleoside analog for comparison. Ninety-two were included study grouped by treatment, i.e., disoproxil fumarate (TDF),...
In March 2020, the COVID-19 pandemic forced Spanish government to declare a state of emergency. A stringent lockdown was enforced, restricting access healthcare services, including chiropractic. Reduced care provision in combination with psychological stress, social isolation and physical inactivity during were shown negatively influence pain conditions. However, data on strategies mitigate impact these conditions are lacking.Upon easing restrictions May 51 chiropractic clinics throughout...
Background: Bone alterations have been observed in the course of HIV infection, characterized by a marked decrease bone mineral density (BMD) and an increase frequency fractures as result fragility. We aim to evaluate early changes metabolic profile possible association with tenofovir other nucleoside nucleotide reverse transcriptase inhibitors (NRTIs) treatment-naïve patients. Methods: conducted prospective study naïve HIV-infected adults (under 50 years), separated into three groups...
Abstract Osteoarthritis (OA) is a degenerative disease characterized by injury of all joint tissues. Our previous study showed that in experimental osteoporosis, chiropractic manipulation (CM) exerts protective effects on bone. We here assessed whether CM might ameliorate OA improving subchondral bone sclerosis, cartilage integrity and synovitis. Male New-Zealand rabbits underwent knee surgery to induce anterior cruciate ligament injury. was performed using the instrument ActivatorV 3...
<h3>Background</h3> Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, although both subchondral bone deterioration and synovial inflammation are also hallmarks of the disease. Chiropractic manipulation (CM) therapeutic approach focused on diagnosis, treatment prevention musculoskeletal disorders. It essentially manual, allowing chiropractor to restore normal range motion function joints, muscles, ligaments. Clinical evidences suggest that CM might...
Introduction Low bone mineral density (BMD) has been described as a non-AIDS-related event in human immunodeficiency virus (HIV)-patients, but it is poorly studied by dual-energy X-ray absorptiometry (DXA) and trabecular score (TBS) young HIV-infected men who have received no previous antiretroviral treatment (ART). Material methods A retrospective study of 56 naïve-HIV-infected under 50 years old with recently diagnosed HIV infection, between May 2012 July 2017. Results The mean age was...
Abstract Background : Low bone mineral density has been described as a non–AIDS (Acquired Immune Deficiency Syndrome)-related event in HIV (human immunodeficiency virus)-patients but it is poorly studied young HIV-infected men who have received no previous antiretroviral therapy. Methods A cross-sectional study of 245 naïve-HIV-infected over 21 and under 50 years old was carried out between January 2014 September 2017. Results The mean age 36.4 years, 68% Caucasian 29.3% Latin American. At...