A5065491541- Musculoskeletal pain and rehabilitation
- Bone health and treatments
- Spine and Intervertebral Disc Pathology
- Parathyroid Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Myofascial pain diagnosis and treatment
- Pain Mechanisms and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Osteoarthritis Treatment and Mechanisms
- Hemoglobinopathies and Related Disorders
- Metabolism, Diabetes, and Cancer
- Soft tissue tumor case studies
- Scoliosis diagnosis and treatment
- Pain Management and Placebo Effect
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Biomedical Research and Pathophysiology
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Advanced Glycation End Products research
- Reproductive Biology and Fertility
- Fetal and Pediatric Neurological Disorders
- Alzheimer's disease research and treatments
Universidad de Málaga
2023
Instituto de Investigación Biomédica de Málaga
2023
Hospital El Escorial
2017-2023
Hospital Universitario Santa Cristina
2017-2023
Canadian Chiropractic Association
2023
Universidad de Alcalá
2007-2019
Hospital Universitario Fundación Jiménez Díaz
2001-2018
Brain Physiology Lab
2012
Vall d'Hebron Hospital Universitari
1988-2011
Universitat Autònoma de Barcelona
2003-2008
Parathyroid hormone–related protein (PTHrP) is shortly upregulated in acute renal injury, but its pathophysiologic role unclear. Investigated was whether PTHrP might act as a profibrogenic factor mice that do or not overexpress the proximal tubule after folic acid (FA) nephrotoxicity, model of damage followed by partial regeneration and patchy tubulointerstitial fibrosis. It found constitutive overexpression these animals conveyed significant increase fibrosis, associated with both...
ABSTRACT. Angiotensin II (AngII) participates in the pathogenesis of kidney damage. Parathyroid hormone (PTH)–related protein (PTHrP), a vasodilator and mitogenic agent, is upregulated during renal injury. The aim this study was to investigate potential relation between AngII PTHrP system kidney. Different methods were used find that both rat mesangial mouse tubuloepithelial cells express type 1 PTH/PTHrP receptor (PTH1R). In these cells, increased mRNA production. contrast, PTH1R...
Treatment of acute renal failure (ARF) would be enhanced by identification factors that accelerate recovery from injury. Parathyroid hormone-related protein (PTHrP) and hepatocyte growth factor (HGF) have been shown to stimulate proliferation in proximal nephron-derived cells. For studying the pathophysiologic roles therapeutic potential these two ARF, transgenic mice overexpressing PTHrP or HGF tubule under direction gamma-glutamyl transpeptidase-I promoter were developed. These display (1)...
Parathyroid hormone-related protein (PTHrP), a mitogenic factor for renal cells, is overexpressed in acute failure (ARF). Recent data support an association between PTHrP and the renin-angiotensin system damaged kidney. The effects of angiotensin II (Ang II) inhibitors (quinapril, enalapril, and/or losartan) on PTH1 receptor (PTH1R) expression rats with either folic acid (FA)- or gentamicin-induced ARF were analyzed. decreased function upregulation PTH1R downregulation induced by...
Degenerative joint disease (DJD) in the lumbar spine is a common condition that associated with chronic low back pain. Excessive loading of joints risk factor for DJD. Changes lordosis significantly redistribute forces weight-bearing on facet and intervertebral discs. However, relationship between DJD has not been characterized men women.We characterised correlation standing radiographic images from 301 adult female male chiropractic patients. was rated using Kellgren-Lawrence scale,...
Background. Hypertrophy of podocytes is characteristic in diabetic nephropathy (DN). Previously, we observed the upregulation parathyroid hormone-related protein (PTHrP) and its receptor PTH1R, experimental DN, associated with renal hypertrophy. Herein, test hypothesis that PTHrP participates mechanism high glucose (HG)-induced podocyte Methods. On mouse podocytes, hypertrophy was assessed by content/cell [H3]leucine incorporation. Podocytes were stimulated HG (25 mM), PTHrP(1–36) (100 nM),...
FSH-secreting pituitary adenomas are extremely rare in children and seldom associated with clinical manifestations of high serum gonadotrophin levels. Thus, most patients have a late presentation, usually as macroadenomas.Two different forms presentation reported: one 12-year-old boy macroorchidism due to microadenoma, probably FSH-secreting, the other 15-year-old panhypopituitarism an FSH-producing macroadenoma. Both presented slightly or FSH low LH inhibin B In first case, microadenoma was...
Hypertrophy of human mesangial cells (HMC) is among the earliest characteristics in patients with diabetic nephropathy (DN). Recently, we observed upregulation parathyroid hormone (PTH)-related protein (PTHrP) experimental DN, associated renal hypertrophy. Herein, first examined whether PTHrP was overexpressed and next assessed putative role this on high glucose (HG)-induced HMC As previously found mice, kidneys from showed an increased tubular glomerular immunostaining for PTHrP. In HMC, HG...
Abstract Psychological stress, social isolation, physical inactivity, and reduced access to care during lockdowns throughout a pandemic negatively impact pain function. In the context of first COVID-19 lockdown in Spain, we aimed investigate how different biopsychosocial factors influence chiropractic patients’ pain-related outcomes vice-versa. A total 648 patients completed online questionnaires including variables from following categories: demographics, outcomes, beliefs, pandemic,...
Evidence suggests that PTHrP [PTH (parathyroid hormone)-related protein] can act as an inflammatory mediator in several pathological settings including cardiovascular disease. The aim of the present study was to determine whether might be involved human platelet activation. We used a turbidimetric method aggregation. expression PTH1R (PTH type 1 receptor) platelets analysed by Western blot and flow cytometry analyses. PTHrP-(1–36) (10−7 mol/l) itself failed modify activation platelets....
Only little is known about the meiotic prophase events in human oocytes, although some of them are involved origin aneuploidies. Here, a broad study pairing and synaptic processes 3263 euploid 2613 aneuploid oocytes (47,XX, +21 47,XX, +13), using different techniques methods, presented order to elucidate characteristics this essential process. Our results reaffirm existence common high efficiency process leading obtainment bivalent for all chromosomes studied cases. Nevertheless, was...
The role of diabetic nephropathy in the outcome acute renal injury (AKI) is not well defined. Herein we evaluate lipopolysaccharide- (LPS-) induced AKI streptozotocin-induced diabetes, as potential Hypoxia Inducible Factor (HIF-1 α ) this condition. Although 6 h after LPS injection all mice developed a decrease function, proteinuric showed better recovery parameter throughout study (72 h). Both HIF-1 and vascular endothelium growth factor (VEGF) were found to be upregulated mice. After...
Low back pain is the leading cause of years lived with disability worldwide. Chiropractors employ different interventions to treat low pain, including spinal manipulative therapy, although mechanisms through which chiropractic care improves are still unclear. Clinical research and animal models suggest that manipulation might modulate plasma levels inflammatory cytokines, have been involved in stages pain. More specifically, serum Tumor Necrosis Factor-alpha (TNF-α) found be elevated...