A5108463971- Neuropeptides and Animal Physiology
- Protein Hydrolysis and Bioactive Peptides
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Antimicrobial Peptides and Activities
- Gene Regulatory Network Analysis
- Gene expression and cancer classification
- Peptidase Inhibition and Analysis
- Pregnancy and preeclampsia studies
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Nerve injury and regeneration
- Evolution and Genetic Dynamics
- Tryptophan and brain disorders
- Infant Nutrition and Health
- Adipose Tissue and Metabolism
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Genetics and Neurodevelopmental Disorders
- Chemical Synthesis and Analysis
- Neuroendocrine regulation and behavior
- Animal testing and alternatives
- Signaling Pathways in Disease
Tel Aviv University
2014-2024
Arthur M. Sackler Gallery
2014
Human Factors (Norway)
2014
Hadassah Medical Center
2003
Oregon National Primate Research Center
1990-1993
University of Copenhagen
1990
Weizmann Institute of Science
1987-1990
The vulnerability of neurons and the irreversibility loss make discoveries neuroprotective compounds fundamentally important. Here, complete coding sequence a novel protein (828 amino acids, pI 5.99), derived from mouse neuroglial cells, is revealed. contained (1) peptide, NAPVSIPQ, sharing structural immunological homologies with previously reported, activity-dependent neurotrophic factor; (2) glutaredoxin active site; (3) zinc binding domain. Gene expression was enriched in hippocampus...
We have recently cloned the mouse activity-dependent neuroprotective protein (ADNP). Here, we disclose cloning of human ADNP (hADNP) from a fetal brain cDNA library. Comparative sequence analysis these two orthologs indicated 90% identity at mRNA level. Several single nucleotide polymorphic sites were noticed. The deduced structure contained nine zinc fingers, proline-rich region, nuclear bipartite localization signal, and homeobox domain profile, suggesting transcription factor function....
Autophagy plays a key role in the pathophysiology of schizophrenia as manifested by 40% decrease BECN1/Beclin 1 mRNA postmortem hippocampal tissues relative to controls. This was coupled with deregulation essential ADNP (activity-dependent neuroprotector homeobox), binding partner MAP1LC3B/LC3B (microtubule-associated protein light chain 3 β) another major constituent autophagy. The drug candidate NAP (davunetide), peptide fragment from ADNP, enhanced ADNP-LC3B interaction. Parallel genetic...
Abstract PolyADP‐ribosylation is a post‐translational modification of nuclear proteins, catalyzed by polyADP‐ribose polymerases (PARPs). In the nucleus, polyADP‐ribosylation PARP‐1 alters protein–protein and protein–DNA interactions, implicated in chromatin remodeling, DNA transcription, repair. Previous results linked activation with long‐term memory formation during learning marine mollusk Aplysia ( Science 2004, 304:1820–1822). Furthermore, was highly activated mammalian cerebral neurons...
Tauopathy, a major pathology in Alzheimer's disease, is also found ∼50% of frontotemporal dementias (FTDs). Tau transcript, product single gene, undergoes alternative splicing to yield 6 protein species, each with either 3 or 4 microtubule binding repeat domains (tau 3R 4R, associated dynamic and stable microtubules, respectively). While the healthy human brain shows 1/1 ratio tau 3R/4R, this may be dramatically changed FTD brain. We have previously discovered that activity-dependent...
Abstract Activity-dependent neuroprotective protein (ADNP), essential for brain formation, was discovered as a leading de novo mutated gene causing the autism-like ADNP syndrome. This syndrome is phenotypically characterized by global developmental delays, intellectual disabilities, speech impediments, and motor dysfunctions. The Adnp haploinsufficient mouse mimics human in terms of synapse density expression patterns, well developmental, motor, cognitive abilities. Peripheral also biomarker...
The octapeptide NAP has been shown to exert neuroprotective properties and reduce neuro-inflammatory responses. aim of the present study was investigate if provides anti-inflammatory effects in acute murine colitis. To address this, C57BL/6 j mice were challenged with 3.5% dextran sulfate sodium from day 0 until 6 induce colitis, either treated intraperitoneally or placebo (NaCl 0.9%) 1 post-induction (p.i.) subjected depth macroscopic, microscopic immunological evaluations. Whereas...
Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific probes. High levels of expression observed as early in 16-day-old embryos. In aging rats, the VIP-mRNA reduced significantly (in cerebral cortex) compared to 21-day-old rats. Our results suggest a role for VIP protein products during embryonal development. During processes decrease may be consequence either reduction transcriptional activity neurons or death VIP-producing cells.
Abstract Mutated disrupted in schizophrenia 1 (DISC1), a microtubule regulating protein, leads to and other psychiatric illnesses. It is hypothesized that stabilization may provide neuroprotection schizophrenia. The NAP ( V SIP Q) sequence of activity-dependent neuroprotective protein (ADNP) contains the SxIP motif, end binding (EB) target, which critical for dynamics leading synaptic plasticity neuroprotection. Bioinformatics prediction FDA approved drugs mimicking SxIP-like motif displace...
NAP (NAPVSIPQ, davunetide) is a microtubule stabilizing peptide drug candidate. Here, we set out to identify NAP-like peptides that provide neuroprotection and reduce tau pathology. were derived using publically available search eng