A5050436288- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Cystic Fibrosis Research Advances
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Respiratory viral infections research
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- High Altitude and Hypoxia
- Respiratory and Cough-Related Research
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- School Health and Nursing Education
- Nosocomial Infections in ICU
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Pneumothorax, Barotrauma, Emphysema
- Neonatal and fetal brain pathology
- Airway Management and Intubation Techniques
- Renal function and acid-base balance
- Foreign Body Medical Cases
Shaare Zedek Medical Center
2015-2025
Hebrew University of Jerusalem
2018-2024
Pulmonary Associates
1996-2012
Tel Aviv University
2002-2009
Ben-Gurion University of the Negev
2006-2007
Hadassah Medical Center
2001
Misgav Ladach
2001
Bikur Cholim Hospital
1990-1996
Geha Mental Health Center
1974
In the last few months world has witnessed a global pandemic due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19). Obviously, this affected individuals differently, with significant impact on populations considered be at high-risk. One such population, was assumed patients primary genetic defect involving components or pathways of immune system. While human immunity against COVID-19 is not fully understood, it is, so far,...
Over the last decade, high-flow nasal cannula (HFNC) therapy has become an increasingly important and popular mode of noninvasive respiratory support. HFNC facilitates delivery humidified heated oxygen at a high flow rate generates positive airway pressure.We present five cases children with OSA without adenotonsillar hypertrophy who were treated HFNC.We demonstrated statistically significant improvement in apnea-hypopnea index nadir saturation this small cohort.We our successful experience...
Abstract PolyADP‐ribosylation is a post‐translational modification of nuclear proteins, catalyzed by polyADP‐ribose polymerases (PARPs). In the nucleus, polyADP‐ribosylation PARP‐1 alters protein–protein and protein–DNA interactions, implicated in chromatin remodeling, DNA transcription, repair. Previous results linked activation with long‐term memory formation during learning marine mollusk Aplysia ( Science 2004, 304:1820–1822). Furthermore, was highly activated mammalian cerebral neurons...
A previous study has suggested that the Human Leukocyte Antigen (HLA) allele DQB1*06:02 affects hypoxic ventilatory response (HVR) but not hypercapnic (HCVR) in an Asian population. The current evaluated relationship Caucasians and Asians. In addition we assessed whether gender or polymorphisms genes participating control of breathing affect HVR HCVR.A re-breathing system was used to measure HCVR 551 young adults (56.8% Caucasians, 30% Asians). HLA-DQB1*06:02 tagged coding variants (PHOX2B,...
Obstructive sleep apnea (OSA) syndrome is a common disorder among children and often associated with significant morbidity. The causes of OSA are related to either fixed upper airway abnormalities such as adenotonsillar hypertrophy, or dynamic laryngomalacia pharyngeal wall collapse. aim the present study was determine prevalence abnormalities, based on endoscopic findings, in normotonic hypotonic polysomnographically documented OSA. records 39 consecutive who underwent bronchoscopy (22...
We performed an observational pilot study of plasma concentrations N-terminal pro-B-type natriuretic peptide (BNP) in premature infants with a diagnosis bronchopulmonary dysplasia (BPD) at 4 weeks age and after 1 month conventional therapy. Thirty-four born before 34 weeks' gestational without cardiac or infectious diseases were included. Serum NT-pro-BNP was measured all neonates age. In the BPD (n = 11), measurements repeated 6 8 under treatment. Specific clinical characteristics collected...
To find the clinical and laboratory criteria that best predict a prolonged fever in children with parapneumonic effusion-associated pneumonia treated conservatively.Retrospective, cohort study.Children admitted to Shaare Zedek Medical Center between January 1, 1997, December 31, 2006, who had been discharged diagnosis of empyema pleurisy.One hundred-twenty were included, all whom antibiotics; 80 patients, thoracic drain was introduced; 23, pleural tap performed; 17 no special procedure...
To determine the normal SpO2 in healthy term newborns at mild altitude (MA, 780 metres) compared with sea level (SL), within context of universal screening for critical congenital heart disease (CCHD).We studied 199 (119 MA and 80 SL) consecutively born newborns. recordings were 24-72 h using Masimo SET Radical-7 on right hand left foot.Mean was lower SL (97.86 ± 1.58 vs 98.28 1.41, p = 0.05) foot (98.49 1.35 98.90 1.16, 0.03). No infant <95% had CCHD. Extrapolating predicted regression...
It is not known whether SpO2 in healthy volunteers affected by sex.To evaluate there are differences between young adult males and females to the already present at birth.We studied two cohorts of patients. The first one consisted (105 102 females). In these patients, was measured as well selected anthropometric variables (height, weight), vital signs (respiratory rate, pulse rate body temperature) obtained data on menstrual cycle phase female participants. For second cohort, we reanalyzed...
Patients with coronavirus 2019 (COVID-19) and obstructive sleep apnoea (OSA) have a worse prognosis than COVID-19 patients without OSA. This study aimed to examine the relationship between OSA risk severity of in undiagnosed diagnosed hospitalized or admitted community hotel were recruited for after recovery during clinic check-up visit 6–8 weeks discharge. At this visit, they answered Epworth Sleeping Scale (ESS) Berlin questionnaire. Demographic clinical details collected from electronic...
<b><i>Background:</i></b> Arterial hemoglobin oxygen saturation (Sa<i>O</i><sub>2</sub>) decreases at an altitude of >1,500 m. There are no reports on normal Sa<i>O</i><sub>2</sub> altitudes between 0 and 1,500 The clinical significance decreased such is unclear. <b><i>Objective:</i></b> To test the hypothesis that in healthy volunteers moderate (MA; 725 m) lower than almost sea level (SL; 43...
A 5-month-old boy who suffered from a leukocyte chemotactic defect underwent flexible bronchoscopy for persistent right upper lobe atelectasis and tachypnea. Ten hours after the procedure he developed fulminant sepsis, died 16 hrs bronchoscopy. Streptococcus pneumoniae (serotype 23) grew bronchoalveolar lavage fluid blood culture taken during sepsis work-up. We, therefore, suggest administering prophylactic antimicrobial therapy immediately following to immunosuppressed children, even when...
Impacted foreign bodies in the esophagus can result respiratory symptoms including stridor and aphonia. Several mechanisms have been proposed to explain these symptoms, but possibility of vocal cord paralysis its cause has not adequately emphasized. Two cases young children with esophageal body are described; both presented 1 aphonia other stridor. In cases, were secondary paralysis. A possible mechanism recurrent nerve injury is proposed.
Right lower quadrant abdominal pain may pose a diagnostic problem in patients with cystic fibrosis. Abdominal ultrasound examination, used commonly the work-up, reveal abnormalities of appendix. However, interpretation such findings is problematic, because appearance gastrointestinal system during routine examination has not been documented The purpose this study was to investigate scans our cohort fibrosis and control subjects.Abdominal were performed prospectively clinic visits...