O. Loboda

ORCID: 0000-0001-8410-6926
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About
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Research Areas
  • Erythropoietin and Anemia Treatment
  • Parathyroid Disorders and Treatments
  • Blood Pressure and Hypertension Studies
  • Electrolyte and hormonal disorders
  • Heart Rate Variability and Autonomic Control
  • Vitamin D Research Studies
  • Human Health and Disease
  • Dialysis and Renal Disease Management
  • Chronic Disease Management Strategies
  • Bipolar Disorder and Treatment
  • Organ Donation and Transplantation
  • Iron Metabolism and Disorders
  • Long-Term Effects of COVID-19
  • Biosimilars and Bioanalytical Methods
  • Muscle and Compartmental Disorders
  • Biomarkers in Disease Mechanisms
  • Pharmacological Effects and Toxicity Studies
  • Healthcare Systems and Public Health
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Medical History and Research
  • Ectopic Pregnancy Diagnosis and Management
  • Medical and Agricultural Research Studies
  • COVID-19 Clinical Research Studies
  • Hydrogen's biological and therapeutic effects
  • Urinary Tract Infections Management

Institute of Nephrology of the National Academy of Medical Sciences of Ukraine
2014-2023

National Academy of Sciences of Ukraine
2023

People living with kidney disease are among the most vulnerable at times of natural or man-made disasters. In addition to their unpredictable course, armed conflicts impose a major threat given disruption infrastructure, sanitation and access food, water medical care. The ongoing war in Ukraine has once more demonstrated importance preparedness, organization, coordination solidarity during face serious challenges dependence on life-sustaining treatment, irrespective whether they remain zone...

10.1093/ndt/gfad053 article EN Nephrology Dialysis Transplantation 2023-03-17

<b>Purpose:</b> Assessment of public knowledge chronic kidney disease (CKD) is an essential step in<b> </b>development CKD prevention and screening programs. Our aim was to estimate the level its predictors in former Soviet Union countries using a validated questionnaire.<br /> <b>Materials methods: </b>This cross-sectional survey conducted 10 adapted online questionnaire. Descriptive statistics were used describe participants’ characteristics assess...

10.29333/ejgm/13517 article EN Electronic Journal of General Medicine 2023-08-01

The war in Ukraine is now entering its ninth year, and a year has passed since the russian army invaded on large scale. A few months ago, Ukrainian Renal Disaster Relief Committee of Association Nephrologists Kidney Transplant Specialists was established began work to provide immediate support kidney patients during war. In this brief report, we present first data collected number receiving replacement therapy, possibility enrolling new patients, availability an autonomous electricity water...

10.31450/ukrjnd.1(77).2023.01 article EN Ukrainian Journal of Nephrology and Dialysis 2023-02-18

Метою нашої роботи було вивчити особливості ВГПТ у пацієнтів з діабетичною хворобою нирок, які лікуються методом гемодіалізу.
 Методи. Ми провели поперечне (одномоментне) дослідження. До дослідження були залучені 263 гемодіалізних вторинним гіперпаратиреозом. У всіх хворих визначали рівні паратгормону (ПТГ), глікозильованого гемоглобіну (HbA1c), 25-гідроксивітаміну Д (вітамін 25-ОН), холестерину (ХС), тригліцеридів (ТГ), лужної фосфатази (ЛФ), С-реактивного білку (СРБ), альбуміну...

10.31450/ukrjnd.1(77).2023.08 article UK Ukrainian Journal of Nephrology and Dialysis 2023-01-18

Метою нашого дослідження було дослідити вплив постковідного синдрому (ПКС) на когнітивні функції та якість життя (ЯЖ) у пацієнтів, які лікуються гемодіалізом (ГД).
 Матеріали методи. Було проведено одномоментне когортне дослідження. До досліджень були залучені 200 лікувались ГД перенесли COVID-19 принаймні за 3 місяці до включення Хворі поділені наявністю ПКС: І групу склали 118 (59%) пацієнтів з ПКС, ІІ групи включено 82 (41%) пацієнти, повністю одужали. ПКС діагностували наявності 1...

10.31450/ukrjnd.4(80).2023.08 article UK cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2023-09-20

Abstract. The occurrence of an emergency situation (ES) forced international (ISN, EDTA/ERA) and national (Turkey) nephrological associations to establish the Renal Disaster Relief Task Force, which is primarily concerned with treatment patients acute kidney injury end-stage renal disease requiring dialysis. war started by RF putting Ukrainian state, society, healthcare system in catastrophic ES. Under these circumstances, all became one most vulnerable categories patients.
 To provide...

10.31450/ukrjnd.3(75).2022.01 article EN cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2022-07-01

The purpose of the work was to determine effect continuous erythropoietin receptor activator (CERA) on autonomic regulation cardiac activity and cardiovascular events in patients treated with online hemodiafiltration (HDF).Materials methods. A total 105 stable chronic HDF were included this prospective observational multicenter study. According CERA treatment, assigned one two groups: 1st group (n = 73) received for at least 6 months 2nd 32) consisted without treatment months. period 3...

10.14739/2310-1210.2019.3.169112 article EN cc-by Zaporozhye Medical Journal 2019-05-31

The paper presents the summary of recommendation statements "KDIGO 2020 clinical practice guideline for diabetes management in chronic kidney disease" translated into Ukrainian.

10.31450/ukrjnd.4(68).2020.09 article EN Ukrainian Journal of Nephrology and Dialysis 2020-11-17

The aim of our study was to determine the relationship processes atherogenesis and indicators endothelial dysfunction with activation lipid peroxidation (LPO) chronic inflammation in patients CKD stages II-IV.
 Material methods. Levels proinflammatory anti-inflammatory cytokines, peroxidation, thickness intima-media (IMT) carotid artery, ankle-brachial index (ABI) were measured 90 stage II-IV (30 - st. II, 31 III 29 IV patients) 30 healthy subjects (control group). correlation analysis...

10.31450/ukrjnd.1(45).2015.03 article EN Ukrainian Journal of Nephrology and Dialysis 2015-01-26

Summury. Data about lipid disorders at different stages of chronic kidney disease (CKD), including those on dialysis are presented in the review. The possible influence dyslipidemia progression CKD, as well onset and cardiovascular complications patients with CKD discussed. questions lipid-lowering therapy use, statins, predialysis, disclosed.

10.31450/ukrjnd.2(42).2014.10 article EN Ukrainian Journal of Nephrology and Dialysis 2014-03-31

The aim of the research: to study efficacy using Solidagoren in complex treatment urinary tract infection (UTI).
 Materials and methods. involved patients (n=51) aged from 18 65 years. All were verified UTI. divided into two groups: main group (n=30) prescribed an antibacterial drug combination with medicinal herbal remedies Solidagoren; comparison (n=21) who underwent only therapy. patient was representative terms demographic indicators, nosology UTI, course disease before began....

10.30841/2307-5112.5.2016.248627 article EN Family Medicine 2016-11-30

There are a small number of works that have studied heart rhythm variability parameters in patients treated with hemodialysis.
 Aim. To investigate the peculiarities Methods. The observational controlled study included 55 hemodialysis, aged 24 to 75 years, including 29 men and 26 women. control group consisted 20 healthy individuals comparable age sex. Heart were investigated all patients.
 Results. In hemodialysis comparatively time most frequency indexes decreased.
...

10.31450/ukrjnd.2(38).2013.07 article EN Ukrainian Journal of Nephrology and Dialysis 2017-12-12

Abstract. The aim of our study was to evaluate the quality life (QoL) in peritoneal dialysis (PD) patients and its relationship with nutritional disorders.
 Methods. 52 PD were included observational cross-sectional study. QoL conducted using a SF-36 assessment questionnaire. Moreover, patients’ nutrition status (NS) examined. For further analysis, divided into four groups according condition NS: first group (n = 22) consisted without disturbance, second =13) mild disorders, third 10)...

10.31450/ukrjnd.1(61).2019.06 article EN cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2019-02-08

Aims: To determine the relationship of prolactin (PL) levels with frequency anemia and level cardiovascular events in patients CKD VD stage.Material methods: A prospective cohort study included 55 stage anemia. Serum were determined all patients.Results discussion: 24 (44%) had normal PL, 31 (56%) elevated PL. It was that PL a negative correlation hemoglobin (r = -0.42; p 0.01), as well albumin -0.38; 0.02). The after 12 months. In significantly higher than PL: 17 (55%) vs 4 (17%) (χ2 8.4,...

10.37321/nefrology.2019.25-05 article EN cc-by Actual Problems of Nephrology 2020-03-19

Despite rapid progress in improving dialysis technology recent years, mortality hemodialysis (HD) patients remains quite high. The main reasons are cardiovascular disease. search of factors that associated with an increased risk adverse clinical events chronic kidney disease (CKD) is urgent problem modern nephrology.
 Prolactin (PL) a unique hormone can perform the functions both and neuropeptide. Among CKD, frequency hyperprolactinemia (HPL) increases decreasing glomerular filtration...

10.31450/ukrjnd.1(69).2021.09 article EN cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2021-01-09

The research objective had been to evaluate the autonomic status in peritoneal dialysis (PD) patients and identify its lipid metabolism interaction.
 Patients methods. During process 40patients examined who received continuous ambulatory (CAPD). was studied using questionnaire (A.N. Wayne test) sympathetic skin response (SSR) by electroneuromyograph «Neuro–MEP–4». 20 conventionally healthy individuals formed control group matched according age sex.
 Results. Obtained data showed...

10.31450/ukrjnd.4(44).2014.04 article EN Ukrainian Journal of Nephrology and Dialysis 2014-09-01

The aim of study was to evaluat the efficacy and safety ofSUFER® (iron (III) sucrose complex) in correction anemia stage 5D chronic kidney disease hemodialysis patients.
 Methods. This included thirty patients undergoing regular (mean age 48,81±3,24 years, mean duration dialysis 30,43±9,25 months) with renal iron deficiency. All were treated SUFER® intravenously 200 mg three times a week. Correction dose determined according manufacturer’s recommendations.
 Results. Mean level...

10.31450/ukrjnd.4(44).2014.07 article EN cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2014-11-24

Aim. The aim was to investigate the use of I1–imidazoline receptor agonist moxonidine as an ‘add–on’ agent and determine its effect on heart rate variability in patients with CKD st. I–III resistant hypertension.
 Methods. We investigated safety efficacy (200–600 mg) a group 35patients whose had prior treatment three or more antihypertensive medications, although without adequate control [systolic blood pressure (SBP) 145–165 mm Hg and/or diastolic BP (DBP) 95–100 Hg]. measured...

10.31450/ukrjnd.3(43).2014.01 article EN Ukrainian Journal of Nephrology and Dialysis 2014-08-23

Anemia is a common complication of CKD. Iron deficiency one leading cause anemia in HD patients. The causes iron these patients are multifactorial. Main factors that contribute to reduction intake and impaired intestinal absorption dietary iron, blood losses, chronic inflammation increased requirements during therapy with erythropoiesis–stimulating agents.
 Aim.The aim was study efficacy safety sucrose (Venofer) anemia.
 Materials methods. This an retrospective, epidemiologic,...

10.31450/ukrjnd.3(43).2014.03 article EN cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2014-08-27

Summary. The aim of the present research was to study influence еpoetin alfa level pro- and anti-inflammatory cytokines in patients with anemia treated by hemodialysis (HD).
 Materials methods: We examined 73patients (mean age 45,85 ±1,21 years). Patients were divided into 2groups: I group - comparison (n = 32), II treatment epoetin 41). levels hemoglobin, C-reactiveprotein, ferritin, albumin, pro-and determined before after both groups. duration 5 months.
 Results: Epoetin...

10.31450/ukrjnd.2(42).2014.03 article EN cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2014-03-27

The article are covering problems for the organization of nephrological care in Kyiv. Regulations according to which assistance is provided city residents listed. Proposals improve aid Kншv presented

10.31450/ukrjnd.1(49).2016.01 article EN Ukrainian Journal of Nephrology and Dialysis 2016-02-23

The aim is to determine the effect of drug pentosan polysulphate at rate disease progression in patients with CKD II - IVst., confirmation lipid lowering action and setting on indicators chronic inflammation.
 Materials methods. Tests conducted one center for 12 weeks. study included 60patients IV st. Patients were divided into 2 groups: group 1 (basic) 30patients addition standard therapy receiving medication, polysulphate, 30 received only therapy. was administered 8 weeks: 100 mg. a...

10.31450/ukrjnd.3(47).2015.03 article EN cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2015-09-07

Introduction. Cytokines play the corresponding role in inflammatory processes and development of endothelial dysfunction therefore take an important place problem systemic chronic inflammation (SCI) patients with kidney disease (CKD), stage V, who are treated methods renal replacement therapy (RRT).
 Aim work was to determine features ofpro- anti-inflammatory cytokines, VEGF CKD V D, depending on method RRT (HD, HDF, PD).
 Materials methods. There were examined 56 CKD, st. RRT:...

10.31450/ukrjnd.4(52).2016.03 article EN cc-by-sa Ukrainian Journal of Nephrology and Dialysis 2016-12-12
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