A5026274142- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Renal Diseases and Glomerulopathies
- Iron Metabolism and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Muscle and Compartmental Disorders
- Adrenal Hormones and Disorders
- Parathyroid Disorders and Treatments
- Inflammatory mediators and NSAID effects
- COVID-19 Clinical Research Studies
- Genetic and Kidney Cyst Diseases
- Ultrasound in Clinical Applications
- Central Venous Catheters and Hemodialysis
- Vasculitis and related conditions
- Renin-Angiotensin System Studies
- Organ Donation and Transplantation
- Adrenal and Paraganglionic Tumors
- Long-Term Effects of COVID-19
- Protease and Inhibitor Mechanisms
- Pharmacy and Medical Practices
- Blood transfusion and management
- Lipoproteins and Cardiovascular Health
- Myasthenia Gravis and Thymoma
- Tuberous Sclerosis Complex Research
- Urticaria and Related Conditions
Social Insurance Saitama Chuo Hospital
2015-2024
Hakodate Central General Hospital
2020-2022
Towada City Hospital
2019
Saiseikai Ibaraki Hospital
2011
Tokyo Medical and Dental University
2009-2010
Tokyo Women's Medical University
2006-2010
Iwate Prefectural Central Hospital
2003
The renin-angiotensin-aldosterone system (RAS) plays a central role in atherosclerosis. To investigate the effects of direct renin inhibitor aliskiren on vascular inflammation, we conducted leukocyte adhesion assays vivo and vitro using novel real-time imaging system.Aliskiren (10 mg/kg/d) or PBS was administered to C57BL/6 mice (6-7 weeks age; Oriental Yeast, Tokyo, Japan) for 2 via an osmotic pump. Blood pressure not significantly changed groups throughout experimental period. A...
Aim: Angiotensin-converting enzyme inhibitors (ACEIs) have been shown to block matrix metalloproteinase (MMP)-9 activity, which plays a role in atherogenesis. MMP-9 activity of macrophages is increased during foam cell formation. To investigate the contribution ACEIs formation, we studied effects an ACEI, imidaprilat, on THP-1 and underlying molecular mechanisms vitro.Methods Results: Pre-treatment with imidaprilat (100 nmol/L, 4 hours) significantly decreased formation induced by oxidized...
Objective Although recent reports have highlighted the benefits of multidisciplinary team care (MTC) for chronic kidney disease (CKD) in slowing progress renal insufficiency, its long-term effects not been evaluated patients with diabetes mellitus (DM). We compared survival rate between MTC and conservative (CC). Methods In this five-year, single-center, prospective, observational study, we examined 24 (mean age 65.5±12.1 years old, men/women 18/6) DM-induced CKD stage ≥3 an clinic. The...
Abstract: Since its experimental introduction in 1960, hemodialysis has become a widely performed and relatively safe procedure. Therapeutic strategies have been developed, the numbers of long‐term survivors therapy increasing. Hemodialysis was introduced at Sangenjaya Hospital October 1970, 16 patients who survived for more than 30 years on since hospital were enrolled this study to investigate characteristics patients. For comparison, 50 less also studied (21 with <10 hemodialysis, 13...
We report a patient with adult-onset nephronophthisis (NPHP) that was identified homozygous full gene deletion of NPHP1 and heterozygous PKD1 mutation. suggest the mutation may have epistatically ameliorated NPHP disease progression screening larger cohorts for similar possible epistatic effects is needed.
Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA) typically occurs anti-neutrophil cytoplasmic autoantibody (ANCA)-positive cases presenting rapidly progressive renal insufficiency and urinary abnormalities induced by primarily necrotizing crescentic glomerulonephritis (NCGN). Recently, ANCA-negative EGPA has also been reported to manifest involvement, such as NCGN or non-NCGN, including membranous nephropathy (MN). Herein, we report a 70-year-old female who presented...
Abstract Background Peritoneal dialysis (PD) is associated with various complications, some of which may result in its discontinuation. Pleuroperitoneal communication (PPC) commonly recognized by the presence a diaphragmatic defect and pressure elevation abdominal cavity due to dialysate. PPC unpredictable prevents continuation PD. We present clinical course pathological findings PD patient after bacterial peritonitis total gastrectomy for gastric neuroendocrine tumors. provide brief review...
We experienced a nosocomial outbreak of coronavirus disease 2019 (COVID-19) from November 2020 to February 2021, during the third wave pandemic in Japan.We retrospectively assessed characteristics and data 20 inpatients undergoing hemodialysis who were hospitalized for treatment diseases other than COVID-19 ("inpatient," IP), 10 outpatients care under outpatient visits ("outpatient," OP).Eleven patients IP group (55%) one OP (10%) died. Kaplan-Meier analysis showed that died more rapidly (p...
A 46-year-old woman was presented with mineralocorticoid excess syndrome and a large mass originating from the right adrenal gland. Clinical examination before adrenalectomy revealed elevated serum concentrations of 18-hydroxy-ll-deoxycorticosterone (18-OH-DOC) both systemically in veins bilaterally. Histopathological immunohistochemical analyses surgical specimen demonstrated hyperplasia outer fasciculata cells, presence cystic mass. The ameliorated her blood pressure (BP) 156/96 mmHg to...
症例は46歳の女性. 29歳出産時に子宮内膜症を指摘された既往がある. 2000年7月原因不明の腎不全に対し透析導入された. 2001年10月より月経時痛が増強し, 2002年4月より月経前後に右自然気胸を繰り返した. 2002年8月より6か月GnRH療法を開始されたが, 月経時に気胸を繰り返した. 2003年7月再度GnRH療法を開始され, 治療中は月経もなく気胸も認めなかった. しかし治療終了後の月経時に気胸が再発し, 同年9月に入院となった. 胸腔鏡で右肺bullaと肺と横隔膜表面に暗赤色のblueberry spotを認め, 外科的に切除した. 切除組織の病理診断は子宮内膜であり月経随伴性気胸と確定診断した. その後気胸の再発はなく, 経過は良好である. 月経随伴性気胸は手術のタイミングにより確定診断を得ることは難しいこと, また透析患者では規則的な月経を有する者が少ないため, 透析患者に合併した月経随伴性気胸は貴重な症例と考え報告する.