A5076240407- Renal Transplantation Outcomes and Treatments
- Hormonal and reproductive studies
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Sexual function and dysfunction studies
- Renal and Vascular Pathologies
- Urinary Bladder and Prostate Research
- Organ and Tissue Transplantation Research
- Renal Diseases and Glomerulopathies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Pelvic floor disorders treatments
- Sexuality, Behavior, and Technology
- Transplantation: Methods and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Sexual Differentiation and Disorders
- Hypothalamic control of reproductive hormones
- Cytomegalovirus and herpesvirus research
- Complement system in diseases
- Renal cell carcinoma treatment
- Metabolism and Genetic Disorders
- Blood groups and transfusion
- Bladder and Urothelial Cancer Treatments
- Neurological Complications and Syndromes
- Prostate Cancer Diagnosis and Treatment
Juntendo University Urayasu Hospital
2016-2024
Juntendo University
2023
Tokyo Women's Medical University
2005-2016
Cleveland Clinic
2006-2014
Tokyo Women's Medical University Hospital
2014
Hitachi (Japan)
2012
Hakodate Central General Hospital
2012
Case Western Reserve University
2008
Kidney Centre
2008
In many experimental models, heart, pancreas and kidney allografts are accepted long-term following costimulation-targeting therapies, whereas skin, lung intestine resist the induction of tolerance under same regimens. We noted that a common feature resistant organs is their constant exposure to commensal microbes hypothesized these microorganisms may stimulate Toll-like receptors (TLRs), promote alloresponses prevent induction. This hypothesis prompts predictions TLR engagement at time...
ABO-incompatible living kidney transplantation (ABO-ILKT) has steadily become more widespread. However, the optimal immunosuppressive regimen for ABO-ILKT remains uncertain. We aimed to determine longitudinal changes in outcomes from compared with those ABO-compatible (ABO-CLKT) over last 25 years. Of 1195 patients who underwent transplantations (LKT) at our institute between 1989 and 2013, 1032-including 247 785 ABO-CLKT cases-were evaluated graft survival, patient infectious adverse...
Normal immune responses stimulated by pathogenic and environmental antigens generate memory T cells that react with donor no currently used immunosuppressive drug completely inhibits T-cell function. While donor-reactive clearly compromise graft outcomes, mechanisms utilized to promote rejection are largely unknown. In this study, we investigated how early endogenous infiltrate express effector function in cardiac allografts. Endogenous CD8 nonsensitized recipients distinguish syngeneic...
ObjectivePoor tolerability to sunitinib with the standard dosing schedule has become an issue. We retrospectively analyzed treatment efficacy and profile of adverse events 2 weeks followed by 1-week-off (Schedule 2/1) compared results 4 2-weeks-off 4/2).
Abstract Rejected MHC-mismatched cardiac allografts in CCR5−/− recipients have low T cell infiltration, but intense deposition of C3d the large vessels and capillaries graft, characteristics Ab-mediated rejection. The roles donor-specific Ab CD4 CD8 responses rejection complete heart grafts by were directly investigated. Wild-type C57BL/6 B6.CCR5−/− (H-2b) A/J (H-2a) had equivalent numbers donor-reactive cells producing IFN-γ, whereas IL-4 increased recipients. Numbers IFN-γ reduced 60% Day...
Increasing detection of acute humoral rejection (AHR) renal allografts has generated the need for appropriate animal models to investigate underlying mechanisms. Murine recipients lacking chemokine receptor CCR5 reject cardiac with marked C3d deposition in parenchymal capillaries and high serum donor-reactive antibody titers, features consistent AHR. The MHC-mismatched from A/J (H-2(a)) donors by B6.CCR5(-/-) (H-2(b)) was investigated. survived longer than 100 days wild-type C57BL/6 normal...
Abstract Objectives To investigate the incidence of asymptomatic unruptured renal artery pseudoaneurysm detected by 3‐D computed tomography arteriography in early period after minimally invasive partial nephrectomy, including laparoscopic and robotic nephrectomy. Methods From February 2012 to November 2013, 101 patients underwent nephrectomy for masses. Computed was carried out 3–4 days surgery; radiologists diagnosed a blinded manner. Factors influencing occurrence were analyzed with...
We tried to establish the technique of retroperitoneoscopic live donor nephrectomy (RPLDN). Between July 2001 and March 2004, 135 renal transplant donors underwent RPLDN. Low (average: 7 mmHg) CO2 gas pressure was employed during procedure. All procedures were performed through a three-port retroperitoneal approach without opening peritoneal cavity. The hand-assisted not used. One hundred twenty-seven cases left eight right nephrectomy. Donor carried out successfully in all patients. In one...
Objectives To investigate the efficacy of tadalafil for patients with benign prostatic hyperplasia and chronic prostatitis/chronic pelvic pain syndrome. Methods Tadalafil 5 mg was given each morning 12 weeks to diagnosed as having either moderate or severe lower urinary tract symptoms. Voiding symptoms were compared between a high (≥4; group) low (<4; subscore National Institutes Health Chronic Prostatitis Symptom Index before after administration. The correlation changes in International...
To evaluate the role of oral glucose tolerance test (OGTT) before transplantation and to examine risk factors for new-onset diabetes after (NODAT) during long-term follow-up renal transplant recipients receiving FK-based therapy.The study evaluated 378 patients pre-transplantation using OGTT assigned them one three groups: Group 1, normal pattern; 2, impaired fasting (IFG)/impaired (IGT) pattern (IFG/IGT); 3, DM pattern.Although incidence NODAT was higher in 3 than groups 1 no significant...
Atherosclerosis is a systematic disease in which plaque builds up inside the arteries that can lead to serious problems related quality of life (QOL). Lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and late-onset hypogonadism (LOH) are highly prevalent aging men significantly associated with reduced QOL. However, few questionnaire-based studies have fully examined relation between atherosclerosis several urological symptoms.The study comprised 303 outpatients who visited our...
Abstract CD4 T cell-dependent mechanisms promoting allograft rejection include expression of inflammatory functions within the graft and provision help for donor-reactive CD8 cell Ab responses. These studies tested cell-mediated MHC-mismatched cardiac allografts in absence both B lymphocytes. Whereas wild-type C57BL/6 recipients depleted cells rejected A/J grafts 10 days, were not cell-deficient B6.μMT−/− cells. Isolated had nearly equivalent vivo alloreactive proliferative numbers spleens...
Abstract Purpose The direct effects of Lepidium meyenii (Maca) on sperm remain unclear. Herein, we examined the effect Maca in vitro fertilization. Methods We fertilization rate a mouse model and acrosome reaction from transgenic mice expressing enhanced green fluorescent protein (EGFP) extract‐containing human tubal fluid (HTF) medium. Using sperm, assessed status via fluorescein isothiocyanate‐conjugated peanut agglutinin (FITC‐PNA) staining performed detailed analysis using motility...
Abstract Introduction Phosphodiesterase type 5 inhibitors (PDE5i) are first-line therapy for most men with erectile dysfunction (ED). If ineffective, vacuum erection devices, intracavernous injections, and penile prosthesis implantation suitable as second- or third-line therapies. However, very few patients select these It is critically important to improve function oral administration of effective agents. Administration L-citrulline transresveratrol in animal experiments has been reported...
Objectives The vacuum erection device (VED) is a second‐line treatment tool recommended in erectile dysfunction (ED) guidelines but has long been unavailable Japan. A new VED, Vigor 2020 ® (A & HB Company Limited, Tokyo, Japan), now manufactured and received medical approval from the Pharmaceuticals Medical Devices Agency We conducted retrospective observational study of ED patients who used clinical practice. Methods analyzed male aged ≥20 years treated with our outpatient clinics....
The effector CD4 T-cell response in wild-type C57BL/6 recipients of single class II MHC-disparate B6.H-2(bm12) cardiac allografts is restricted by CD4(+)CD25(+) regulatory T cells (Tregs) resulting long-term allograft survival. To investigate the role chemokine receptors might play Treg function, this study tested requirement for CCR5 on Tregs to suppress alloimmune allografts. In contrast survival (>100 days), were acutely rejected within 25 days CCR5(-/-) with intense infiltration cells....
Sexuality is very important for men's health. Currently, phosphodiesterase type 5 inhibitors (PDE5i) remain the first-line therapy erectile dysfunction, and no other oral drugs or drinks are approved used clinically to treat male libido orgasm dysfunction. In reference a pharmaceutical dosage document, growing health consciousness said have boosted yearly sales of supplement more than 170 billion yen (1.58 US dollars) in Japan. We created drink comprised testofen, L-citrulline, resveratrol,...
Objective. To assess the long-term graft survival of right-sided retroperitoneoscopic live donor nephrectomy (RPLDN), we compared outcomes right- and left-sided RPLDN. Methods. Five hundred thirty-three patients underwent renal transplantation with allografts procured by RPLDN from July 2001 to August 2010 at our institute. Of these, 24 (4.5%) cases were selected for (R-RPLDN) according criteria kidney selection. Study variables included peri- postoperative clinical data. Results. No...
Premature ejaculation (PE) has negative personal consequences, such as distress, bother, frustration, and/or the avoidance of sexual intimacy. In Japan, no oral drugs or devices are approved used clinically to treat PE. The Men's Training Cup Keep (MTCK), a masturbation aid, was developed for MTCK offers 5 grades tightness and strength.We aimed investigate efficacy in patients who unable delay ejaculation.Inclusion criteria were 20- 60-year-old men feeling distressed frustrated by PE had...