A5007162129- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Magnetic Properties and Synthesis of Ferrites
- Hydrogels: synthesis, properties, applications
- Dental Implant Techniques and Outcomes
- Iron oxide chemistry and applications
- Silk-based biomaterials and applications
- Advancements in Battery Materials
- Advanced Sensor and Energy Harvesting Materials
- Characterization and Applications of Magnetic Nanoparticles
- Nanoparticles: synthesis and applications
- Wound Healing and Treatments
- Polymer composites and self-healing
- Nanoplatforms for cancer theranostics
- Dental materials and restorations
- Photodynamic Therapy Research Studies
- Maternal and Neonatal Healthcare
- Innovative concrete reinforcement materials
- Innovations in Concrete and Construction Materials
- Tissue Engineering and Regenerative Medicine
- Recycled Aggregate Concrete Performance
- 3D Printing in Biomedical Research
- Multiferroics and related materials
Universidade Nova de Lisboa
2015-2025
University of Lisbon
2014-2024
Instituto Politécnico de Lisboa
2014-2015
Superparamagnetic iron oxide nanoparticles with enhanced magnetic properties were produced by combining a chemical process and heat treatment, resulting in improved heating effects reduced cancer cell survival during hyperthermia assays.
Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in magnetic hyperthermia, where their therapeutic efficacy depends on efficient heat generation. However, intracellular uptake of SPIONs has been shown to reduce dissipation capacity, limiting hyperthermia performance. To address this challenge, we explored the use small-molecule endocytosis inhibitors block SPIONs’ vitro . stabilized with 3-aminopropyl triethoxysilane (APTES) were evaluated an advanced cutaneous...
Several problems and limitations faced in the treatment of many diseases can be overcome by using controlled drug delivery systems (DDS), where active compound is transported to target site, minimizing undesirable side effects. In situ-forming hydrogels that injected as viscous liquids jellify under physiological conditions biocompatible clay nanoparticles have been used DDS development. this work, polymer–clay composites based on Pluronics (F127 F68) nanoclays were developed, aiming at a...
The physical properties of the cubic and ferrimagnetic spinel ferrite LiFe5O8 has made it an attractive material for electronic medical applications. In this work, nanosized crystallites were synthesized by a novel eco-friendly sol-gel process, using powder coconut water as mediated reaction medium. dried powders heat-treated (HT) at temperatures between 400 1000 °C, their structure, morphology, electrical magnetic characteristics, cytotoxicity, hyperthermia assays performed. heat treatment...
Ferrites have been widely studied for their use in the biomedical area, mostly due to magnetic properties, which gives them potential be used diagnostics, drug delivery, and treatment with hyperthermia, example. In this work, KFeO2 particles were synthesized a proteic sol-gel method using powdered coconut water as precursor; is based on principles of green chemistry. To improve its base powder obtained was subjected multiple heat treatments at temperatures between 350 1300 °C. The samples...
The small pore size of electrospun membranes prevents their use as three-dimensional scaffolds. In this work, we produced polycaprolactone (PCL) fibrous with expanded pores by incorporating chitosan (CS) granules into the PCL solution. Scanning electron microscopy images confirmed presence CS embedded in fibers, creating an open structure. Tensile testing results showed that addition decreased both Young’s modulus and yield stress, but co-electrospun (PCL fibers blended CS-containing fibers)...
Cancer is a major worldwide public health problem. Although there have already been astonishing advances in cancer diagnosis and treatment, the scientific community continues to make huge efforts develop new methods treat cancer. The main objective of this work prepare, using green sol–gel method with coconut water powder (CWP), nanocomposite mixture Gd3Fe5O12 ZnFe2O4, which has never synthesized previously. Therefore, we carried out structural (DTA-TG X-ray diffraction), morphological...
Hybrid scaffolds obtained by combining two or more biopolymers are studied in the context of tissue regeneration due to possibility achieving new functional properties structural features. The aim this work was produce a type hybrid polycaprolactone (PCL)/chitosan (CS) electrospun mat through controlled deposition CS flakes interspaced between PCL fibers. A poly(ethylene oxide) (PEO) solution used transport with size. This, and solution, were simultaneously onto rotatory mandrel...
Photodynamic therapy is a minimally invasive procedure used in the treatment of several diseases, including some types cancer. It based on photosensitizer molecules, which, presence oxygen and light, lead to formation reactive species (ROS) consequent cell death. The selection molecule important for efficiency; therefore, many molecules such as dyes, natural products metallic complexes have been investigated regarding their photosensitizing potential. In this work, phototoxic potential...
Cancer is one of the leading causes death worldwide. Conventional treatments such as surgery, chemotherapy, and radiotherapy have limitations severe side effects. Magnetic hyperthermia (MH) an alternative method that can be used alone or in conjunction with chemotherapy to treat cancer. Cobalt ferrite particles were synthesized using innovative biogenic sol–gel powder coconut water (PCW). The obtained powders subjected heat between 500 °C 1100 °C. Subsequently, they characterized by thermal,...
Traditional bioactive glass powders are typically composed of irregular particles that can be packed into dense configurations presenting low interconnectivity, which limit bone ingrowth. The use novel biocomposite sphere formulations comprising factors as fillers most advantageous, it simultaneously allows for packing the in a 3-dimensional manner to achieve an adequate interconnected porosity, enhanced biological performance, and ultimately superior new formation. In this work, we develop...
Bone replacement is one of the major medical procedures in oral surgery field due to progressive ageing population and illness or trauma younger age groups. The use implants without biological activity effective osseointegration increases chances implant failure. This work aims improve interaction between bone by using Bioglass 45S5 (BG)/hydroxyapatite (HAp) mixtures, including copper-, zinc-, cerium-doped BG, as well co-doping mentioned metals, coatings produced CoBlastTM technique. All...
Open-cell foams based on hydroxyapatite (HAp) can mimic the extracellular matrix (ECM) to better replace damaged hard tissues and assist in their regeneration processes. Aerogels of HAp nanowires (NW) with barium titanate (BT) particles were produced characterized regarding physical chemical properties, bioactivity, vitro cytotoxicity. Considering role piezoelectricity (mainly due collagen) surface charges bone remodeling, all BT particles, size 280 nm 2 3 µm, contained BaTiO3 piezoelectric...