A5088286280- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Characterization and Applications of Magnetic Nanoparticles
- Iron oxide chemistry and applications
- Advanced Sensor and Energy Harvesting Materials
- Bone Tissue Engineering Materials
- Electrohydrodynamics and Fluid Dynamics
- Magnetic Properties and Synthesis of Ferrites
- Polysaccharides Composition and Applications
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Advancements in Battery Materials
- Advanced Drug Delivery Systems
- Dental Implant Techniques and Outcomes
- Tribology and Lubrication Engineering
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Nanocomposite Films for Food Packaging
- Polymer Nanocomposite Synthesis and Irradiation
- Polymer Surface Interaction Studies
- Therapeutic Uses of Natural Elements
- Electromagnetic wave absorption materials
- Coagulation and Flocculation Studies
- Microencapsulation and Drying Processes
Universidade Nova de Lisboa
2015-2025
University of Lisbon
2021-2024
Faculdade de Tecnologia e Ciências
2016-2017
Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, drug delivery and hyperthermia. Hyperthermia is a technique used cancer treatment which consists inducing temperature of about 41–45 °C cancerous cells through NPs an external field. Chemical precipitation was to produce iron 9 nm size coated with oleic acid trisodium citrate. The influence both stabilizers on heating ability vitro...
Conventional bone cancer treatment often results in unwanted side effects, critical-sized defects, and inefficient cancer-cell targeting. Therefore, new approaches are necessary to better address patient's recovery. One solution may reside the combination of regeneration scaffolds with magnetic hyperthermia. By incorporating pristine superparamagnetic iron oxide nanoparticles (pSPIONs) into additively manufactured we created structures for hyperthermia regeneration. For this, hydroxyapatite...
Superparamagnetic iron oxide nanoparticles with enhanced magnetic properties were produced by combining a chemical process and heat treatment, resulting in improved heating effects reduced cancer cell survival during hyperthermia assays.
Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in magnetic hyperthermia, where their therapeutic efficacy depends on efficient heat generation. However, intracellular uptake of SPIONs has been shown to reduce dissipation capacity, limiting hyperthermia performance. To address this challenge, we explored the use small-molecule endocytosis inhibitors block SPIONs’ vitro . stabilized with 3-aminopropyl triethoxysilane (APTES) were evaluated an advanced cutaneous...
Cancer theranostics is a recent concept that aims to combine in the same device diagnostic and therapeutic features.Magnetic nanoparticles (mNPs) are commonly used as critical part of these systems due their ability respond an external magnetic field.Consequently, mNPs can generate heat when alternating field applied enhance image contrast resonance.However, direct administration intravenously or directly tumor lead undesired side effects because mNP elimination by macrophages leakage...
Composite ferrogels were obtained by encapsulation of magnetic nanoparticles at two different concentrations (2.0 and 5.0 % w/v) within mixed agarose/chitosan hydrogels having agarose (1.0, 1.5 2.0% (w/v)) a fixed concentration chitosan (0.5% (w/v)). The morphological characterization carried out scanning electron microscopy showed that dried composite present pore sizes in the micrometer range. Thermogravimetric measurements higher degradation temperatures than blank chitosan/agarose...
Colorectal cancer is the third most frequent type of and second leading cause cancer-related deaths worldwide. The majority cases are diagnosed at a later stage, to need for more aggressive treatments such as chemotherapy. 5-Fluorouracil (5-FU), known its high cytotoxic properties has emerged chemotherapeutic agent. However, it presents several drawbacks lack specificity short half-life. To reduce these drawbacks, strategies have been designed namely chemical modification or association drug...
Several problems and limitations faced in the treatment of many diseases can be overcome by using controlled drug delivery systems (DDS), where active compound is transported to target site, minimizing undesirable side effects. In situ-forming hydrogels that injected as viscous liquids jellify under physiological conditions biocompatible clay nanoparticles have been used DDS development. this work, polymer–clay composites based on Pluronics (F127 F68) nanoclays were developed, aiming at a...
The physical properties of the cubic and ferrimagnetic spinel ferrite LiFe5O8 has made it an attractive material for electronic medical applications. In this work, nanosized crystallites were synthesized by a novel eco-friendly sol-gel process, using powder coconut water as mediated reaction medium. dried powders heat-treated (HT) at temperatures between 400 1000 °C, their structure, morphology, electrical magnetic characteristics, cytotoxicity, hyperthermia assays performed. heat treatment...
Gellan gum is a biocompatible and easily accessible polysaccharide with excellent properties to produce microparticles as drug delivery systems. However, the production methods often fail in reproducibility, compromising translational potential of such In this work, gellan gum-based was optimized using coaxial air flow method, an inexpensive reproducible method. A design experiments used identify main parameters that affect microparticle optimization, focusing on diameter dispersibility....
Composite biomaterials that combine osteoconductive and osteoinductive properties are a promising approach for bone tissue engineering (BTE) since they stimulate osteogenesis while mimicking extracellular matrix (ECM) morphology. In this context, the aim of present research was to produce polyvinylpyrrolidone (PVP) nanofibers containing mesoporous bioactive glass (MBG) 80S15 nanoparticles. These composite materials were produced by electrospinning technique. Design experiments (DOE) used...