A5030938588- Hydrogels: synthesis, properties, applications
- Polysaccharides Composition and Applications
- Advanced Drug Delivery Systems
- Polysaccharides and Plant Cell Walls
- 3D Printing in Biomedical Research
- Tribology and Lubrication Engineering
- Plant Surface Properties and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Neonatal skin health care
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Microencapsulation and Drying Processes
- Spacecraft and Cryogenic Technologies
- Methane Hydrates and Related Phenomena
- Polymer-Based Agricultural Enhancements
- Polymer Foaming and Composites
- Cyclone Separators and Fluid Dynamics
- Natural Fiber Reinforced Composites
- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- Liquid Crystal Research Advancements
- Block Copolymer Self-Assembly
- Additive Manufacturing and 3D Printing Technologies
- biodegradable polymer synthesis and properties
University of Lisbon
2022-2024
Universidade Nova de Lisboa
2019-2024
A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 as the continuous phase and alginate microparticles dispersed of this system. It is well known that forms gel when added to water in an appropriate concentration certain temperature range. may be injected, its sol state, act physiological environment. rheological characterization allowed most (15.5 wt%) contents (5 10 determined. Methylene blue...
Gellan gum is a biocompatible and easily accessible polysaccharide with excellent properties to produce microparticles as drug delivery systems. However, the production methods often fail in reproducibility, compromising translational potential of such In this work, gellan gum-based was optimized using coaxial air flow method, an inexpensive reproducible method. A design experiments used identify main parameters that affect microparticle optimization, focusing on diameter dispersibility....
Polysaccharides such as alginate and gellan gum are biocompatible easily accessible biopolymers with excellent properties to produce microparticles drug delivery systems. However, the production methods often fail in reproducibility, compromising translational potential of In this work, made from were optimized using coaxial air flow method, an inexpensive reproducible method. A Design Experiments was used identify main parameters that affect microparticle’s optimization, focusing on...
This study investigates the rheological behavior of cellulose microfiber suspensions derived from kahili ginger stems (Hedychium gardnerianum), an invasive species, in two adhesive matrices: a commercial water-based (Coplaseal®) and casein-based made non-food-grade milk, referred to as K S samples, respectively. Rheological analyses were performed using oscillatory rotational shear tests conducted at 25 °C, 50 75 °C assess materials’ viscoelastic properties more comprehensively. Oscillatory...
Due to the high complexity of some treatments, there is a need develop drug-delivery systems that can release multiple drugs/bioactive agents at different stages treatment. In this study, thermoresponsive injectable dual-release system was developed with gellan gum/alginate microparticles (GG:Alg) within Pluronic hydrogel composed mixture F127 and F68. The increase in F68 ratio decrease lead higher transition temperatures. addition GG:Alg decreased temperatures linear tendency. aqueous...
Cancer is a disease that continues to greatly impact our society. Developing new and more personalized treatment options crucial decreasing the cancer burden. In this study, we combined magnetic polysaccharide microparticles with Pluronic thermoresponsive hydrogel develop multifunctional, injectable drug delivery system (DDS) for hyperthermia applications. Gellan gum alginate were loaded superparamagnetic iron oxide nanoparticles (SPIONs) without coating. The microparticles’ registered...
Biopolymers present ideal properties to be used in wound dressing solutions. By mixing two oppositely charged macromolecules it is possible form polyelectrolyte complex (PEC) based cryogels using lyophilization. Their application the biomedical field limited due their sterilization requirements, as conventional methods compromise physicochemical properties. ScCO2 appears an alternative method for decontamination. This work assessed several cryogel PEC formulations, chitosan-pectin,...
first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Size: Aa Line Spacing: Column Width: Background: Open AccessAbstract A Thermoresponsive Injectable Microparticles/Hydrogel Drug Delivery System for Cancer Treatment † by Henrique Carrêlo, Paula I. P. Soares, João Paulo Borges and Maria Teresa Cidade * CENIMAT/i3N, Materials Science Department, Nova School of Sciences Technology, New University Lisbon, 2829-516 Caparica, Portugal Author to whom correspondence...