A5000722519- Wildlife Ecology and Conservation
- Species Distribution and Climate Change
- Bat Biology and Ecology Studies
- Primate Behavior and Ecology
- Rangeland Management and Livestock Ecology
- Immune Cell Function and Interaction
- Genetic diversity and population structure
- Cancer Genomics and Diagnostics
- Wildlife-Road Interactions and Conservation
- T-cell and B-cell Immunology
- Human-Animal Interaction Studies
- Ecology and Vegetation Dynamics Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Microbial Metabolic Engineering and Bioproduction
- Animal Ecology and Behavior Studies
- Animal Behavior and Welfare Studies
- Cancer-related Molecular Pathways
- Avian ecology and behavior
- Cancer Diagnosis and Treatment
- Rangeland and Wildlife Management
New Cross Hospital
2024
Maharishi Markandeshwar University, Mullana
2024
Government Medical College and Hospital
2021-2024
Narayana Health
2019-2024
University of Oxford
2021-2024
Yeungnam University
2024
Amity University
2015-2023
IEC University
2023
MRC Human Immunology Unit
2021-2022
MRC Weatherall Institute of Molecular Medicine
2022
The structure of a transposon specifying the biodegradation chlorobenzoate contaminants is described. Tn5271 17-kilobase (kb) that resides in plasmid or chromosome Alcaligenes sp. strain BR60 and allows this organism to grow on 3- 4-chlorobenzoate. flanked by directly repeated sequence 3201 base pairs (bp), which turn 110-bp inverted repeats. 3.2-kb sequence, designated IS1071, exists multiple copies genome involved recombination catabolic genes into strain. Sequence analysis revealed repeat...
Egr2 and 3 are important for maintaining immune homeostasis. Here we define a fundamental function of operating as checkpoint that controls the transition between clonal expansion differentiation effector T cells. deficiency resulted in defective but hyperactivation excessive cells response to viral infection. Conversely, sustained expression enhanced severely impaired differentiation. bound controlled genes regulating proliferation (Myc Myb) repressors (Bcl6, Id3), while repressing...
Global climate change is causing unprecedented impacts on biodiversity. In India, there little information available regarding how affects biodiversity at the taxon/group level, and large-scale ecological analyses have been lacking. this study, we demonstrated applicability of eBird GBIF (Global Biodiversity Information Facility), produced national-scale forecasts to examine possible terrestrial avifauna in India. Using data collected by citizen scientists, developed fine-tuned Species...
Abstract Mast cell products and high levels of type 2 cytokines are associated with severe dengue disease. Group innate lymphoid cells (ILC2) type-2 cytokine-producing that activated by epithelial mast cell-derived lipid mediators. Through ex vivo RNAseq analysis, we observed ILC2 during acute viral infection, show an impaired I-IFN signature in We circulating permissive for virus infection vitro, particularly when through prostaglandin D (PGD ). underwent productive which was inhibited...
Abstract We evaluated the status of tigers Panthera tigris and their prey in Panna Tiger Reserve using occupancy surveys, camera-trap mark-recapture population estimation, distance sampling along foot transects, 2006. Forest Range tiger landscape (3,500 km 2 ) estimated by 1,077 surveys 5 each was 29% ± SE 1. Within occupied Ranges a mean 68% 7 forest Beats had signs. A total 800 nights yielded 24 captures seven individual adult within an effective trap area 185.0 15.8 -2 . The best model...
Wildlife management in rapid changing landscapes requires critical planning through cross cutting networks, and understanding of landscape features, often affected by the anthropogenic activities. The present study demonstrates fine-scale spatial patterns genetic variation contemporary gene flow red panda (Ailurus fulgens) populations with respect to connectivity Kangchenjunga Landscape (KL), India. found about 1,309.54 km2 area suitable for KL-India, which 62.21% fell under Protected Area...
Abstract T-bet is important for differentiation of cytotoxic CD8 and Th1 CD4 T cells. We have discovered that Egr2 3 are potent inhibitors function in effector were essential to suppress Th2 Th17 conditions vitro also control IFN-γ–producing cells response virus infection. Together with 3, induced naive by Ag stimulation, but expression was inhibited Th1–inducing cytokines. found physically interact the T-box domain T-bet, blocking DNA binding inhibiting T-bet–mediated production IFN-γ....
T follicular helper (Tfh) cells support differentiation of B to plasma and high affinity antibody production in germinal centers (GCs), Tfh requires the function cell lymphoma 6 (BCL6). We have now discovered that early growth response gene 2 (EGR2) EGR3 directly regulate expression Bcl6 cells, which is required for their regulation GC formation. In absence EGR2 -3, BCL6 defective, leading impaired resulting a failure form GCs following virus infection defects antiviral antibodies. Enforced...
Understanding the mechanism of coexistence, where carnivores adapt to humans and vice versa in shared landscape, is a key determinant long-term carnivore conservation but yet be comprehensively examined. We explored coexistence striped hyena ( Hyaena hyaena) landscape Sawai Mansingh Wildlife Sanctuary (SMS WLS), Rajasthan, from November 2019 March 2021. used data derived motion sensors-based surveys, satellite remote sensing images, household questionnaires understand socio-ecological,...
Despite massive global conservation strategies, tiger populations continued to decline until recently, mainly due habitat loss, human-animal conflicts, and poaching. These factors are known affect the genetic characteristics of decrease local effective population sizes. The Terai Arc Landscape (TAL) at foothills Himalaya is one 42 source sites tigers around globe. Therefore, information on how landscape features anthropogenic fine-scale spatial structure variation in TAL needed develop...
SUMMARY Cell-mediated T-helper type-1 (Th1) responses play a vital role in the immunopathogenesis of genital infections caused by herpes simplex virus 2 (HSV-2). We investigated Th HSV-2 infection at different disease stages analysing production cytokines HSV-stimulated peripheral blood mononuclear cells (PBMCs). IFN-γ decreased over time following recurrence, whereas levels IL-10, and to lesser extent IL-2, remained elevated during this period. In addition, PBMCs from asymptomatic...
Abstract Background and Objectives: Although cancer in adolescents young adults (AYAs) is increasingly an area of focus, there a paucity clinical epidemiological data from developing countries. Our objective was to analyze the geographical distribution, sex ratio, histology, disease patterns cancers AYA. Materials Methods: All patients aged 15-29 years with diagnosis who were registered two hospitals New Delhi during 12-month period January 2014 December included. Basic demographic...
Population estimates of tigers (Panthers tigris) are affected by movement patterns the sexes. We evaluated sex-specific heterogeneity to estimate tiger population at Ranthambhore Tiger Reserve, western Rajasthan, India. also compared attributes obtained using a likelihood-based spatially explicit capture–recapture (SECR) method with traditional approaches that use alternate information on animal space used an effective sampled area around traps. 122 photo-captures 27 individuals (14 F and 13...