A5014490741- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Sphingolipid Metabolism and Signaling
- Parasites and Host Interactions
- Bacteriophages and microbial interactions
- Dermatology and Skin Diseases
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Helminth infection and control
- Cytomegalovirus and herpesvirus research
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
University of Oxford
2018-2024
MRC Human Immunology Unit
2019-2023
MRC Weatherall Institute of Molecular Medicine
2018-2023
We recently reported the discovery of a new parasite-derived protein that functionally mimics immunosuppressive cytokine transforming growth factor (TGF)-β. The Heligmosomoides polygyrus TGF-β Mimic (Hp-TGM) shares no homology to any family member, however it binds mammalian receptor and induces expression Foxp3, canonical transcription both mouse human regulatory T cells. Hp-TGM consists five atypical Complement Control Protein (CCP, Pfam 00084) domains, each lacking certain conserved...
Abstract Mast cell products and high levels of type 2 cytokines are associated with severe dengue disease. Group innate lymphoid cells (ILC2) type-2 cytokine-producing that activated by epithelial mast cell-derived lipid mediators. Through ex vivo RNAseq analysis, we observed ILC2 during acute viral infection, show an impaired I-IFN signature in We circulating permissive for virus infection vitro, particularly when through prostaglandin D (PGD ). underwent productive which was inhibited...
Group A
Cutaneous group 2 innate lymphoid cells (ILC2) are spatially and epigenetically poised to respond barrier compromise associated immunological threats. ILC2, lacking rearranged antigen-specific receptors, primarily activated by damage-associated cytokines with type cytokine production. To investigate ILC2 potential for direct sensing of skin pathogens allergens, we performed RNA sequencing derived from in vivo challenged human or blood. We detected expression
Abstract Atopic dermatitis (AD) is a common, relapsing–remitting inflammatory skin disease that associated with other disorders such as food allergy, allergic asthma and rhinitis, leading to increased rates of morbidity mortality. The discovery CD1a involvement in AD pathogenesis through the presentation permissive neolipid antigens generated by house dust mite phospholipase A2 (PLA2) enhanced our understanding complex network T-cell targets contribute development. As well defining agonist...