Abstract Nighttime light (NTL) data from the Defense Meteorological Satellite Program (DMSP)/Operational Linescan System (OLS) and Visible Infrared Imaging Radiometer Suite (VIIRS) on Suomi National Polar-orbiting Partnership satellite provide a great opportunity for monitoring human activities regional to global scales. Despite valuable records of nightscape DMSP (1992–2013) VIIRS (2012–2018), potential historical archive NTL observations has not been fully explored because severe...

Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is growing in incidence but treatment options remain limited, particularly for late stage disease. As cirrhosis principal risk state HCC development, markers to detect early within this patient population are urgently needed. Perturbation epigenetic marks, such as DNA methylation (5mC), a hallmark human cancers, including HCC. Identification regions with consistently altered 5mC levels circulating cell free (cfDNA)...

City lights, fishing boats, and oil fields are the major sources of nighttime therefore light images provide a unique source to map human beings their activities from outer space. While most scholars focused on application remote sensing in urbanization regional development, actual much wider. This paper summarized applications into such as estimation socioeconomic parameters, monitoring urbanization, evaluation important events, analyzing pollution, fishery, etc. For promising progress is...

Plant metal tolerance proteins (MTPs) play major roles in enhancing resistance to heavy and homeostasis. However, the role of MTPs genes tomato, which is one most popular crops, still largely limited. Hence, we investigated genome-wide study tomato MTPs, including phylogenetic, duplication, gene structure, ontology previous transcriptomic data analysis. Moreover, expression behaviour under various metals stress has rarely been investigated. In current study, eleven MTP candidate were...

High spatiotemporal population data are critical for a wide range of applications (e.g. urban planning and management, risk assessment, epidemic control). However, such still not widely available due to the limited knowledge complex human activities. Here we proposed downscaling framework estimating hourly dynamics in Beijing by integrating remote sensing social data. First, generated two baseline maps during sleep work times using dasymetric method. Second, functional zones random forest...

Aerosol loadings and their spatial distribution are among the most important atmospheric information needed for a range of applications such as air quality monitoring, climate research, public health. A key measure aerosol quantity is optical depth (AOD) it has been routinely observed from space by Earth observing satellites/instrument, especially Moderate Resolution Imaging Spectroradiometer (MODIS). Despite its global coverage daily temporal resolution, MODIS Multi-Angle Implementation...

RNA N6-methyladenosine (m6A) plays diverse roles in metabolism and its deregulation contributes to tumor initiation progression. Clear cell renal carcinoma (ccRCC) is characterized by near ubiquitous loss of VHL followed mutations epigenetic regulators PBRM1, SETD2, BAP1. Mutations a histone H3 lysine 36 trimethylase (H3K36me3), are associated with reduced survival, greater metastatic propensity, metabolic reprogramming. While m6A H3K36me3 separately implicated tumorigenesis, may participate...

Inherited rickets of Corriedale sheep is characterized by decreased growth rate, thoracic lordosis and angular limb deformities. Previous outcross backcross studies implicate inheritance as a simple autosomal recessive disorder. A genome wide association study was conducted using the Illumina OvineSNP50 BeadChip on 20 related comprising 17 affected 3 carriers. homozygous region 125 consecutive single-nucleotide polymorphism (SNP) loci identified in all sheep, covering 6 Mb ovine chromosome...

Abstract Background and Aims Chronic HCV infection is a leading etiologic driver of cirrhosis ultimately HCC. Of the approximately 71 million individuals chronically infected with HCV, 10%‐20% are expected to develop severe liver complications in their lifetime. Epigenetic mechanisms including DNA methylation histone modifications become profoundly disrupted disease processes disease. Approach Results To understand how influences epigenome whether these events remain as “scars” following...

Alpha‐1 antitrypsin deficiency (AATD) liver disease is characterized by marked heterogeneity in presentation and progression, despite a common underlying gene mutation, strongly suggesting the involvement of other genetic and/or epigenetic modifiers. Variation clinical phenotype has added to challenge detection, diagnosis, testing new therapies patients with AATD. We examined contribution DNA methylation (5‐methylcytosine [5mC]) AATD because 5mC responds environmental cues its deregulation...

Scrotal hernia in pigs is a complex trait likely affected by genetic and environmental factors. A large-scale association analysis of positional functional candidate genes was conducted four previously identified genomic regions linked to susceptibility on Sus scrofa chromosomes 2 12, as well the fifth region around 67 cM chromosome 2, respectively. In total, 151 out 416 SNPs discovered were genotyped successfully. Using family-based we found that surrounding ELF5, KIF18A, COL23A1 NPTX1...

Summary Chondrodysplasia in T exel sheep is a recessively inherited disorder characterized by dwarfism and angular deformities of the forelimbs. A genome‐wide association study using I llumina O vine SNP 50 B ead C hip on 15 diagnosed as affected eight carriers descended from three rams was conducted to uncover genetic cause. homozygous region 25 consecutive single nucleotide polymorphism ( ) loci identified all sheep, covering 1 M bp ovine chromosome 4. Seven positional candidate genes –...

This paper examines the mechanisms by which risk perception affects farmers' timing of grain sales and role played preference based on 2019 China Family Database Household Finance Survey. The results indicate that high is more likely to lead farmers current compared with intertemporal sales. It reveals underlying reason for indifference in increased under constraints, causes risky returns from lower than certain utility comparison. further found has a substitution effect

Disruption of the epigenome is a hallmark human disease, including liver cirrhosis and HCC. While genetic heterogeneity an established effector pathologic phenotypes, epigenetic less well understood. Environmental exposures alter liver-specific DNA methylation landscape influence onset cancer. Given that currently available treatments are unable to target frequently mutated genes in HCC, there unmet need for novel therapeutics prevent or reverse damage leading hepatic tumorigenesis, which...

To investigate candidate genes involved in human type 2 diabetes (T2D) for obesity-related phenotypes pigs. Statistical association analyses of with fat deposition were realized a pig reference family constructed by two breeds, Berkshire and Yorkshire. Extensive sequencing was then attempted to discover the causative polymorphism. Genes implied T2D development, TCF7L2, WFS1, FTO, SLC30A8, GCKR, mapped on Sus scrofa chromosomes 14, 8, 6, 4, 3, respectively. Only TCF7L2 significantly...

The majority of the research using night-time data has focused on terrestrial environment, while light flooding our oceans is less studied. Meanwhile, given rapid development imaging technology at night, remotely sensed can now provide a great opportunity to improve understanding spatiotemporal distribution over large areas. In this article, we used monthly cloud-free imagery from Suomi National Polar-Orbiting Partnership (Suomi NPP) Visible Infrared Imaging Radiometer Suite Day/Night Band,...

Urban connectivity information is important for regional planning of sustainable development goals. However, there are still challenges in deriving the spatial relationship among urban areas. The nighttime light data measure anthropogenic phenomenon remotely and can be seen as a unique source monitoring expansion human activities. This study presents an object-based approach investigating patches by incorporating Suomi National Polar-Orbiting Partnership Visible Infrared Imaging Radiometer...

Histone‐lysine N ‐methyltransferase SETD2 (SETD2), the sole histone methyltransferase that catalyzes trimethylation of lysine 36 on H3 (H3K36me3), is often mutated in clear cell renal carcinoma (ccRCC). mutation and/or loss H3K36me3 linked to metastasis and poor outcome ccRCC patients. Epithelial‐to‐mesenchymal transition (EMT) a major pathway drives invasion various cancer types. Here, using novel kidney epithelial lines isogenic for , we discovered inactivation EMT promotes migration,...

Abstract Objective —To evaluate the associations between 14 biological candidate genes and scrotal hernias in pigs. Animals —1,534 Pietrain-based pigs, including 692 individuals from 298 pig families 842 male pigs without family information. Procedures —Pigs were classified as affected or unaffected for hernias. Single nucleotide polymorphisms of analyzed via PCR assays genotyped. Statistical analyses performed on family-trio case-control data. Results —2 involved collagen metabolism...

Summary Cryptorchidism (CO) as a common developmental defect in purebred dogs causes health concerns of reduced fertility and increases risk testicular malignancies. A total 49 single nucleotide polymorphisms (SNPs) discovered from 20 candidate genes was investigated to analyse their associations with CO Siberian Huskies. The sibling‐transmission disequilibrium test on 38 discordant full‐sibs revealed seven SNPs the collagen type II α 1 ( COL2A1 ) gene were significantly (p < 0.05) or...

Summary Cryptorchidism is a condition whereby one or both testes fail to descend into the scrotal sac. Here, we performed genome‐wide association study (GWAS) with case–control analysis using GEMMA software accounting for population structure and BayesB approach in GenSel applied every 1 Mb window of SNP s haplotypes. The haplotypes were constructed from genealogical tree 204 Siberian Huskies. analyses identified six putative genomic candidate regions on CFA 6, 9, 24, 27 X. These explained...