A5018146430- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Inflammation biomarkers and pathways
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Intensive Care Unit Cognitive Disorders
- Sleep and Wakefulness Research
- Cardiac Ischemia and Reperfusion
- Congenital heart defects research
- Congenital Diaphragmatic Hernia Studies
- Research studies in Vietnam
- Pediatric Pain Management Techniques
- Lung Cancer Treatments and Mutations
- Industrial Gas Emission Control
- Pain Management and Opioid Use
- Autophagy in Disease and Therapy
- Obstructive Sleep Apnea Research
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
- Pharmacological Effects and Toxicity Studies
- Zebrafish Biomedical Research Applications
- Ferroptosis and cancer prognosis
- Thermal Regulation in Medicine
- Sleep and related disorders
Hangzhou Medical College
2017-2025
Zhejiang Provincial People's Hospital
2009-2025
Soochow University
2020
Second Affiliated Hospital of Soochow University
2020
Zhejiang University
2008
Propofol, commonly used as an intravenous anesthetic during pregnancy, can easily penetrate the placental barrier, potentially affecting fetal heart development. This study aims to investigate propofol's impact on developing zebrafish structure and function, identify potential drug targets. Zebrafish embryos were exposed different concentrations of propofol (0.5, 1, 5 mg/L) observe changes in larval function (heart rate). In vitro cell experiments conducted assess effects at cardiomyocyte...
Restoration of blood supply through medical or surgical intervention is a commonly adopted method for acute myocardial ischemia, but also trigger cardiac ischemia/reperfusion injury. Studies have shown that remifentanil (REM) displays cardioprotective effects. In this study, the effects REM on HCMEC viability were examined before and after induction H/R using Cell Counting Kit-8 assays. Wound healing Matrigel angiogenesis assays performed to assess migration angiogenesis, respectively....
Non-small cell lung cancer (NSCLC) is one of the most lethal malignant tumors. It has been shown that general anesthetic agents, propofol and astragaloside IV (AS-IV) both exert antitumor effects in NSCLC. However, combination with AS-IV NSCLC remain unclear. Cell counting kit-8, EdU Transwell assays were performed to evaluate viability, proliferation, migration. apoptosis autophagy observed by flow cytometric analysis TUNEL LC3 staining, respectively. notably enhanced anti-proliferative,...
Ropivacaine is commonly applied for local anesthesia and may cause neurotoxicity. Dexmedetomidine (DEX) exhibits neuroprotective effects on multiple neurological disorders. This study investigated the mechanism of DEX pretreatment in ropivacaine-induced neurotoxicity.Mouse hippocampal neuronal cells (HT22) human neuroblastoma (SH-SY5Y) were treated with 0.5 mM, 1 2.5 5 mM ropivacaine. Then pretreated different concentrations (0.01 μM, 0.1 10 100 μM) before ropivacaine treatment....
BackgroundCD molecules plays a vital role in gastric cancer (GC). We used bioinformatics analysis methods to develop prognosis related CD risk signature; On the other hand, we experiments further explore function and mechanism of differentially expressed prognostic (TREM1) GC.MethodsKaplan-Meier survival univariate Cox regression were evaluate overall molecule genes cancer. ROC curve Kaplan-Meier curves analyze predictive value signature by "survival timeROC" R packages. GSEA, Cibersortx...
The motive of this study was to investigate the interaction between polymorphisms in MDR1 gene and anesthetic effects following pediatric tonsillectomy. In total, 240 children undergoing tonsillectomy with preoperative propofol-remifentanil anesthesia were selected. Genomic DNA extracted from peripheral blood after operation, 2677 G>T/A, 1236 C>T 3435 detected by direct sequencing. We tested mean arterial pressure, diastolic systolic heart rate at several time-points: T0 (5 mins repose), T1...
This study aims to investigate the effect of placenta-derived mesenchymal stem cells (PMSCs) administration on tissue repair following acute lung injury (ALI). PMSCs were transplanted intravenously a mouse model lipopolysaccharide-induced ALI. The therapeutic effects determined by evaluating several indicators, including pathology; wet/dry ratio lungs; blood gas analysis; total protein content, cell numbers, and activity myeloperoxidase (MPO) in bronchial alveolar lavage fluid (BALF); levels...
Objective To compare multiple organ dysfunction score (MOBS), the sequential failure assessment (SOFA) and logistic (LOBS) in predicting hospital mortality severe sepsis. Methods Four hundred three patients admitted to ICU from December 2004 November 2007 with a diagnosis of sepsis were enrolled this study. Their MOBS, SOFA, LOBS Acute Physiology Chronic Health Evaluation (APACHE) Ⅱ at admission highest during hospitalization respectively recorded collated regard mortality. The...
Background: The nucleoplasmin/nucleophosmin (NPM) family was previously regarded as a critical regulator during disease development, and its mediation in carcinogenesis has achieved intensive attention recently. However, the clinical importance functional mechanism of NPM3 lung adenocarcinoma (LUAD) have not been reported yet. Objective: This study aimed to investigate role significance development progression LUAD, including underlying mechanisms. Methods: expression pan-cancer analyzed via...
Triggering receptor expressed on myeloid cells(TREM-1)is a new cellular surface molecule.It belongs to immune globin superflamily and its member includes TREM-1,TREM-2,TREM-like transcript(TLT)-1 TLT-2.TREM-1 mainly neutrophils mature monoeytes as well macrophages. It is in coordination with the signal pathway mediated by Toll-like receptors,enhances production of pro-inflammatory factors such TNF-α IL-β,amplifies inflammatory reaction. Meanwhile.these chemotaets lyphocytes,which indicates...