A5066543249- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Surgical Simulation and Training
- MicroRNA in disease regulation
- Explainable Artificial Intelligence (XAI)
- Social Media in Health Education
- Imbalanced Data Classification Techniques
- Genomics and Chromatin Dynamics
- Global Health and Surgery
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Anatomy and Medical Technology
- Developmental Biology and Gene Regulation
- RNA regulation and disease
- Cerebrospinal fluid and hydrocephalus
- Abdominal Trauma and Injuries
- RNA and protein synthesis mechanisms
- Ethics and Social Impacts of AI
- Cardiac, Anesthesia and Surgical Outcomes
- Cell death mechanisms and regulation
- Retinal and Optic Conditions
- Neurogenesis and neuroplasticity mechanisms
- Diversity and Career in Medicine
University of Cambridge
2020-2025
Rothman Orthopaedics
2023
Addenbrooke's Hospital
2020-2022
Barts Health NHS Trust
2021
American Association of Neurological Surgeons
2021
National Institute for Health Research
2020
King's College London
2018-2020
Haverford College
2016-2017
National Research Council Canada
2004-2016
Stephen F. Austin State University
2015
Sexual dimorphisms are typically attributed to the hormonal differences arising once sex differentiation has occurred. However, in some sexually dimorphic diseases that differ frequency but not severity, cannot be logically connected hormones. Therefore, we asked whether any aspect of sexual dimorphism could chromosomal rather than differences. Cells taken from mice at d 10.5 postconception (PC) before differentiation, 17.5 PC after first embryonic assertion hormones, and postnatal day 17...
Background MicroRNAs (miRNAs) are short non-coding RNAs predicted to regulate one third of protein coding genes via mRNA targeting. In conjunction with key transcription factors, such as the repressor REST (RE1 silencing factor), miRNAs play crucial roles in neurogenesis, which requires a highly orchestrated program gene expression ensure appropriate development and function diverse neural cell types. Whilst previous studies have highlighted select groups during development, there remains...
Data-trained predictive models see widespread use, but for the most part they are used as black boxes which output a prediction or score. It is therefore hard to acquire deeper understanding of model behavior, and in particular how different features influence prediction. This important when interpreting behavior complex models, asserting that certain problematic attributes (like race gender) not unduly influencing decisions. In this paper, we present technique auditing black-box lets us...
<sec> <title>BACKGROUND</title> Photoplethysmography (PPG) is an optical method for measuring blood volume changes in microcirculation, through non-invasive photodetection. It has become a widespread and essential clinical tool, used pulse oximeters wearable devices. However, technical aspects of PPG make it susceptible to intrinsic bias, with the potential adversely affect particular patient consumer populations. Developments technology, increasingly driven by existing datasets as opposed...
The teaching of human anatomy and surgical procedures in medicine has traditionally relied on cadaveric dissections, textbook illustrations more recently digital simulations. Although tried tested, these methods do not come without limitations; cadavers have limited availability are expensive to procure store, two dimensional simulations lack tactile feedback. Innovations such as 3D printing aim bridge perceived education gaps, provide the most comprehensive practical learning experience...
Transcription factors regulate gene expression by interacting with their specific DNA binding sites. Some transcription factors, particularly those involved in initiation, always bind close to start sites (TSS). Others have no such preference and are functional on even tens of thousands base pairs (bp) away from the TSS. The Cyclic-AMP response element (CRE) protein (CREB) binds preferentially a palindromic sequence (TGACGTCA), known as canonical CRE, also other CRE variants. CREB can...
Low-income and-middle-income countries (LMICs) are increasing investment in research and development, yet there remains a paucity of neurotrauma published by those LMICs. The aim this study was to understand neurosurgeons' experiences of, aspirations for, ability conduct disseminate clinical LMICs.This two-stage inductive qualitative situated within the naturalistic paradigm. This committed an interpretivist way knowing (epistemology), considered reality subjective multiple (ontology). Data...
Confounding any genome-scale analysis of gene expression after cerebral ischemia is massive suppression protein synthesis. This inefficient translation questions the utility examining profiles total transcripts. Our approach to such postischemic profiling in mouse by microarray was concentrate on those mRNAs bound polyribosomes. In our proof-of-principle study, polysomally and unbound were subjected analysis: 1,161 transcripts that we found increase ischemia, only 36% addition expected...
Introduction: Undergraduate student conferences provide networking opportunities for students interested in exploring a speciality. The ability to meet with like-minded students, engage senior clinicians and experience the practical side of speciality are valuable shaping career trajectory undergraduates. We report our developing national undergraduate neurosurgery conference – combined project between medical King's College London School Medicine department at Hospital NHS Foundation...
The increasing shift toward a more generalized medical undergraduate curriculum has led to limited exposure subspecialties, including neurosurgery. lack of standardized teaching may result in insufficient coverage core learning outcomes. Social media (SoMe) education are becoming an increasingly accepted and popular way for students meet objectives outside formal school teaching. We delivered series case-based discussions (CbDs) over SoMe attempt needs neurosurgery determine whether...
A rat gene, designated DNaseY, encoding a 36 kDa endonuclease was identified and cloned. Sequence analysis of the cDNA showed it to be homologue human DNAS1L3. The DNaseY gene product had 42% identity DNaseI, including conserved critical active site residues, essential disulfide bridge, calcium binding domain, signal peptide, as well 2 3 signature boxes. Significantly, nuclear localization signals more basic (pI 9.5) than DNaseI 4.8). contained number exons similar that separated by much...
To explore the value and potential of qualitative research to neurosurgery provide insight understanding this underused methodology. The definition is critically discussed heterogeneity within field inquiry explored. articulated through its contribution complex clinical problems. resolve some misunderstanding research, paper discusses design choices. We approaches that use techniques but are not, necessarily, situated a paradigm in addition how philosophy aids researchers conduct...