A5036639421- Radiation Dose and Imaging
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Radioactive contamination and transfer
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
- Effects of Radiation Exposure
- Risk Perception and Management
- Microtubule and mitosis dynamics
- Reproductive Biology and Fertility
- Radioactivity and Radon Measurements
- Plant Genetic and Mutation Studies
- HER2/EGFR in Cancer Research
- Genetics, Aging, and Longevity in Model Organisms
- Carcinogens and Genotoxicity Assessment
- Nuclear and radioactivity studies
- Cancer therapeutics and mechanisms
- Virology and Viral Diseases
- Chronic Lymphocytic Leukemia Research
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Radiation Therapy and Dosimetry
- Respiratory viral infections research
Canadian Nuclear Safety Commission
2018-2024
Children's Minnesota
2024
Minnesota West Community & Technical College
2024
Ottawa Hospital
2005-2022
Ottawa Hospital Research Institute
2011-2022
Institut Paoli-Calmettes
2021
Centre Hospitalier de l’Université de Montréal
2021
Creative Commons
2019
Institut de Cancérologie Strasbourg
2019
Université de Montréal
2018
The reactivity of aluminum and several other divalent trivalent metallic cations toward chromatin from rat brain liver has been investigated. Two criteria are used to determine the relative these chromatin. first involves ability ions compact fibers point where precipitates. second criterion measures interfere with accessibility exogenous structural probes (nucleases) Of tested, nickel, cobalt, zinc, cadmium, mercury were most reactive chromatin, on basis their induce precipitation in...
Classical apoptotic cell death can be defined by certain morphological and biochemical characteristics that distinguish it from other forms of death. One such feature, which is a hallmark apoptosis, DNA fragmentation. In dying cells, cleaved an endonuclease fragments the chromatin into nucleosomal units, are multiples about 180-bp oligomers appear as ladder when run on agarose gel. Here, we present commonly used methods conventional gel electrophoresis to analyze fragmented nuclei in cells....
Measles is readily spread to susceptible individuals, but no longer endemic in the United States. In March 2011, measles was confirmed a Minnesota child without travel abroad. This first identified case-patient of an outbreak. An investigation initiated determine source, prevent transmission, and examine measles-mumps-rubella (MMR) vaccine coverage affected community. Investigation response included follow-up, post-exposure prophylaxis, voluntary isolation quarantine, early MMR for...
Survival curve behaviour and degree of correspondence between the linear-quadratic (LQ) model experimental data in an extensive dose range for high rates were analysed. Detailed clonogenic assays with irradiation given 0.5 Gy increments a total varying from 10.5 to 16 performed. The cell lines investigated were: CHOAA8 (Chinese hamster fibroblast cells), U373MG (human glioblastoma CP3 DU145 prostate carcinoma lines). analyses based on chi2-statistics Monte Carlo simulation experiments. A...
Abstract SOX2 is a key neurodevelopmental gene involved in maintaining the pluripotency of stem cells and proliferation neural progenitors astroglia. Two evolutionally conserved enhancers, SRR1 SRR2, are controlling expression during neurodevelopment; however, molecular mechanisms regulating their activity not known. We have examined DNA methylation histone H3 acetylation at both enhancers NT2‐D1 progenitors, neurons astrocytes, to establish role epigenetic cell‐type‐specific expression....
Polar body emission is a specialized cell division throughout the animal kingdom, serving to reduce chromosome ploidy while preserving egg cytoplasm. Critical polar are asymmetric positioning of meiotic spindle prior anaphase, with one pole attached oocyte cortex, and simultaneous membrane protrusion during subsequent cytokinesis. We have shown that, Xenopus maturation, small GTPase Cdc42 promotes classical RhoA contractile ring forms constricts at base protrusion. report here that treating...
OBJECTIVE: Electronic immunization information systems (IISs) are now established in almost all US states. We used the IIS Minnesota, Georgia, and Connecticut for data as source of 1 2 control groups to measure pentavalent rotavirus vaccine (RV5) effectiveness (VE) using case-control methodology. PATIENTS AND METHODS: Case-subjects were vaccine-eligible children who presented 5 hospitals or emergency departments with gastroenteritis had antigen detected stool during any 3 seasons...
Purpose: The occurrence and predictors of delirium in older adults hospitalized for coronavirus disease 2019 (COVID-19) have not been well described. Highlighting the association with inflammatory markers may be useful identifying delirium. This study aimed to determine prevalence incidence explore its C-reactive protein (CRP). Patients Methods: cohort aged 65 a COVID-19 diagnosis took place at an academic healthcare institution between April May 2020. was diagnosed by positive...
The purpose of toxicology is to protect human health and the environment. To support this, Organisation for Economic Co-operation Development (OECD), operating via its Extended Advisory Group Molecular Screening Toxicogenomics (EAGMST), has been developing Adverse Outcome Pathway (AOP) approach consolidate evidence chemical toxicity spanning multiple levels biological organization. knowledge transcribed into AOPs provides a structured framework transparently organize data, examine weight...
Purpose: In 2012, the Organization for Economic Cooperation and Development (OECD) formally launched Adverse Outcome Pathway (AOP) Programme. The AOP framework has potential predictive utility in identifying early biological endpoints linked to adverse effects. It uses weight of correlative evidence identify a minimal set measurable key events that link molecular initiating an outcome. AOPs have capability knowledge gaps priority areas future research based on relevance addition, can...
There are no recent descriptions of measles hospitalizations and complications in US children despite outbreaks within the past decade-including 2 Minnesota (2011 2017). The objective our study was to describe complications, hospital management resource utilization for hospitalized at a children's hospital.Retrospective case series (0-18 years age) (observation/inpatient diagnosis code measles) Children's Minnesota, January 1, 2011, September 2017. Descriptive statistics were...
One of the goals Canadian National Transplant Research Program (CNTRP) is to develop novel therapies for acute rejection that could positively affect graft outcomes with greater efficacy or less toxicity. To innovative management strategies kidney rejection, new modalities need be compared current clinical practices. However, there are no standardized practices concerning T cell-mediated (TCMR).To describe clinicians' practice patterns in diagnosis, treatment, and monitoring TCMR...
Decades of research to understand the impacts various types environmental occupational and medical stressors on human health have produced a vast amount data across many scientific disciplines. Organizing these in meaningful way support risk assessment has been significant challenge. To address this other challenges modernizing chemical assessment, Organisation for Economic Cooperation Development (OECD) formalized adverse outcome pathway (AOP) framework, an approach consolidate knowledge...
ABSTRACT In this paper, we show that there is a two‐step process of DNA fragmentation in apoptosis; first cleaved to large fragments 50–300 kb are subsequently smaller oligonucleosomes some, but not all cells. Significantly, only the stage considered essential for cell death since some cells, example human MCF7 breast carcinoma cells and NT2 neuronal do behavior still display normal nuclear morphological apoptotic changes. usually produce small blocking second (internucleosomal) prevents...
Existing and future nuclear fusion technologies involve the production use of large quantities tritium, a highly volatile, but low toxicity beta‐emitting isotope hydrogen. Tritium has received international attention because public scientific concerns over its release to environment potential health impact internalization. This article provides brief summary current state knowledge both biological regulatory aspects tritium exposure; it also explores gaps in this recommendations on best ways...