A5089296908- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Intensive Care Unit Cognitive Disorders
- Stroke Rehabilitation and Recovery
- Functional Brain Connectivity Studies
- Sleep and related disorders
- Pharmaceutical Practices and Patient Outcomes
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Anesthesia and Sedative Agents
- Neurological Disease Mechanisms and Treatments
- Treatment of Major Depression
- Health Systems, Economic Evaluations, Quality of Life
- EEG and Brain-Computer Interfaces
- MRI in cancer diagnosis
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- Psychiatric care and mental health services
- Healthcare Decision-Making and Restraints
- Cognitive Functions and Memory
- Patient Satisfaction in Healthcare
Akershus University Hospital
2013-2025
Norwegian University of Science and Technology
2018-2025
St Olav's University Hospital
2022-2024
University of Oslo
2008-2018
Neurology, Inc
2013
Oslo University Hospital
2008
Neuropathological correlates of Alzheimer's disease (AD) emerge years before dementia. Biomarkers preceding cognitive decline and reflecting the causative processes can potentially aid early intervention diagnosis. Diffusion tensor imaging (DTI)
To determine whether white matter (WM) memory network changes accompany early cognitive impairment and these represent early, pathologically independent axonal affection, we combined WM diffusion tensor imaging cortical morphometric measurements of normal control subjects, patients with only subjective (SCI), or mild (MCI).We included 66 SCI MCI 21 subjects from a university-hospital-based clinic in cross-sectional study. Morphometric analysis was performed FreeSurfer, Tract-Based Spatial...
Mild cognitive impairment (MCI) may take several forms, and amnestic MCI (aMCI) has been recognized as an early stage of Alzheimer's Disease (AD). Impairment in executive functions including attention (eMCI) be indicative neurodegenerative conditions. Executive is frequently found aMCI, it significant for prognosis, patients with eMCI go on to develop AD. Recent studies have changes white matter integrity more sensitive than measures cortical atrophy. Studies genetic high-risk groups using...
Mild cognitive impairment (MCI) may affect multiple neuropsychological domains. While amnestic MCI is associated with Alzheimer's disease, patterns of brain pathology in non-amnestic subtypes have been less studied. Twenty-three patients attention/executive (a/e MCI), seen at a university-based memory clinic, and 23 normal controls, matched according to age, gender, education, were included this study. All subjects assessed test battery, including tests memory, attention executive function,...
While APOE ε4 is the major genetic risk factor for Alzheimer's disease (AD), amyloid dysmetabolism an initial or early event predicting clinical and important focus secondary intervention trials.To improve identification of cases with increased AD risk, we evaluated recruitment procedures using pathological CSF concentrations A 42 (pA) as markers in a multi-center study Norway.In total, 490 subjects aged 40-80 y were included after response to advertisements media coverage memory clinics...
An estimated 40% of patients experience cognitive impairment 3 months after a stroke. However, there is lack knowledge about improvement This exploratory study aims to comprehend the prevalence and patterns within initial poststroke. At 1 week poststroke, 85 aged 40-79 years with supratentorial ischemic stroke Mini-Mental State Examination score ≥23 underwent neuropsychological testing learning, recall, recognition, working memory, verbal fluency, naming, executive function, attention,...
<b><i>Aims:</i></b> To improve early diagnosis of dementia disease, this study investigates correlates cognitive complaints and test performance in patients with subjective (SCI) mild (MCI) impairment. <b><i>Methods:</i></b> Seventy from a memory clinic, aged 45-79, score 2 (n = 23) or 3 47) on the Global Deterioration Scale, were included. CSF biomarkers [Aβ<sub>42</sub>, total tau (T-tau) phosphorylated (P-tau)], depressive...
<b>BACKGROUND AND PURPOSE:</b> Mild cognitive impairment (MCI) may affect several domains, including attention and reasoning, but is often first characterized by memory deficits. The purpose of this study was to ask these 2 questions: 1) Can levels CSF tau proteins amyloid beta 42 peptide explain thinning the cerebral cortex in patients with MCI? 2) How are brain morphometry, biomarkers, apolipoprotein E (APOE) allelic variation related episodic function <b>MATERIALS METHODS:</b> Hippocampal...
Alzheimer's disease (AD) and cerebrovascular (CVD) including chronic small vessel of the brain (SVD) are most frequent causes dementia. AD is associated with metabolism amyloid precursor protein (APP) low levels amyloid-β peptide (Aβ) X-42 in cerebrospinal fluid (CSF). CVD SVD established risk factors for AD, white matter lesions (WML) surrogate markers also reduced CSF AβX-42. A cohort survey was performed to examine whether or acute affects APP explore a potential association between WML...
To evaluate the relationship between (a) pathologic levels of cerebrospinal fluid (CSF) total tau as an index intensity ongoing neuronal degeneration and (b) longitudinal changes in white matter (WM) integrity patients with mild cognitive impairment (MCI).Participants gave written informed consent, Norwegian committee for medical research ethics approved study. Thirty MCI nonpathologic CSF levels, nine 16 age-matched healthy control subjects underwent diffusion-tensor imaging at baseline...
Objective To test the hypothesis that depressive symptoms correlate with Alzheimer's disease (AD) type changes in CSF and structural functional imaging including hippocampus volume, cortical thickness, white matter lesions, Diffusion tensor (DTI), fluoro-deoxy-glucose positron emission tomography (FDG-PET) patient subjective (SCI) mild (MCI) cognitive impairment. Method In 60 patients, were assessed using Geriatric Depression Scale. The subjects underwent MRI, 18F-FDG PET imaging, lumbar...
Abstract Objectives Preclinical Alzheimers disease (AD) patients may or not show cognitive impairment on testing. AD biomarkers are central to the identification of those at low, intermediate, high risk later dementia due . We investigated biomarker distribution in identified as subjective decline ( SCD ), amnestic aMCI and nonamnestic (na MCI ) mild subtypes. In addition, clinical groups were compared with controls downstream neuroimaging markers. Materials Methods Cerebrospinal fluid CSF...
Background Z-hypnotics or z-drugs are commonly prescribed for insomnia and sleep difficulties in older adults. These drugs associated with adverse events dependence not recommended long-term use. Despite evidence of adults being more sensitive to a wide array clinical guidelines advocating limiting use, inappropriate use this population is still prevalent. Previous intervention studies have focused mainly on prescriber information. Simple, individually designs less studied. Brief (BI)...
We present a patient with left anteromedial thalamic lesion an amnesic syndrome. The underwent neuropsychological testing, cerebrospinal fluid (CSF) analyses, magnetic resonance imaging (MRI) [T2, flair, and diffusion tensor (DTI)] [18F]-2-fluoro-deoxy-d-glucose positron emission tomography (FDG-PET) to assess indirect effects of lesions on cortical function.A 67-year-old right-handed woman was admitted university-based memory unit because concentration problems. Neuropsychological testing...
Disease and medication use in older age is a consequence of age-related declining health. Multimorbidity followed by polypharmacy common. Central nervous system depressing (CNSD) drugs such as opioids, benzodiazepines z-hypnotics are not recommended for long-term adults but many. We aimed to assess mortality change health-related quality life (HRQoL) with CNSDs. A prospective observational study was conducted at Akershus University Hospital, Norway, 2017-2019, follow-up 2021-2022, including...
Abstract Subjective and mild cognitive impairment (SCI MCI) are etiologically heterogeneous conditions. This poses problems for assessment of pathophysiological mechanisms risk conversion to dementia. Neuropsychological, imaging, cerebrospinal fluid (CSF) findings serve distinguish Alzheimer’s disease (AD) other etiological subgroups. Tau-molecules stabilize axonal microtubuli; high CSF total tau (T-tau) reflects ongoing damage consistent with AD. Here, we stratify patients by T-tau...
Introduction: Amyloid beta 1-43 (Aβ43), with its additional C-terminal threonine residue, is hypothesized to play a role in early Alzheimer's disease pathology possibly different from that of amyloid 1-42 (Aβ42). Cerebrospinal fluid (CSF) Aβ43 has been suggested as potential novel biomarker for predicting conversion mild cognitive impairment (MCI) dementia disease. However, the relationship between CSF and established imaging biomarkers never assessed. Material Methods: In this observational...
Abstract Objective Delirium, a common complication after stroke, is often overlooked, and long-term consequences are poorly understood. This study aims to explore whether delirium in the acute phase of stroke predicts cognitive psychiatric symptoms three, 18 36 months later. Method As part Norwegian Cognitive Impairment After Stroke Study (Nor-COAST), 139 hospitalized patients (49% women, mean ( SD ) age: 71.4 (13.4) years; National Institutes Health Scale (NIHSS) 3.0 (4.0)) were screened...
Mild cognitive impairment (MCI), especially amnestic, often represents pre-dementia Alzheimer's disease, characterized by medial temporal lobe atrophy, while white matter (WM) alterations are insufficiently described. We analyze both cortical morphometric and WM diffusivity differences in amnestic versus non-amnestic subtypes ask if memory tract affection related independently of atrophy. Forty-nine patients from a university-hospital based clinic with score 3 on the Global Deterioration...
To investigate putative interacting or distinct pathways for hippocampal complex substructure (HCS) atrophy and cognitive affection in early-stage Alzheimer's disease (AD) cerebrovascular (CVD), we recruited healthy controls, patients with mild impairment (MCI) poststroke patients. HCSs were segmented, quantitative white-matter hyperintensity (WMH) load cerebrospinal fluid (CSF) amyloid-β concentrations determined. The WMH was higher poststroke. All examined smaller amyloid-positive MCI than...
Central nervous system depressants (CNSDs) such as opioids, benzodiazepine and Z-hypnotics are commonly used. However, CNSDs may influence cognitive function, especially in older hospitalised patients with comorbidities. The aim was to examine the association between CNSD use function patients. We assessed global domain specific among patients, including covariates for comorbidity, anxiety depression. Cross-sectional hospital-based study. Data collected consecutively from inpatients at...
Abstract Background During discharge from hospital, older patients and physicians discuss the plan for managing patients’ health at home. If not followed home, it can result in poor medication management, readmissions, or other adverse events. Comorbidities, polypharmacy cognitive impairment may create challenges patients. We assessed conversations between in-patients treatment activities information, with emphasis on role of function ongoing conversation. Methods collected 11 videos...
Abstract Background Post-stroke neurocognitive disorder, though common, is often overlooked by clinicians. Moreover, although the Montreal Cognitive Assessment (MoCA) has proven to be a valid screening test for even more time saving tests would preferred. In our study, we aimed determine diagnostic accuracy of Clock Drawing Test (CDT) post-stroke disorder and association between CDT MoCA. Methods This study part Norwegian Impairment After Stroke multicentre prospective cohort following...