A5059331869- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
- Healthcare Systems and Public Health
- Cardiac, Anesthesia and Surgical Outcomes
- Vascular Procedures and Complications
- Central Venous Catheters and Hemodialysis
- Cardiac tumors and thrombi
- Coronary Artery Anomalies
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Health and Mental Health
- Cardiac pacing and defibrillation studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammation biomarkers and pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Non-Invasive Vital Sign Monitoring
- Adrenal and Paraganglionic Tumors
Hospital Braga
2016-2024
Universidade do Porto
2014-2019
Universität Hamburg
2014
University Medical Center Hamburg-Eppendorf
2014
Imperial College London
2014
Berlin Heart (Germany)
2014
Septic shock is a life-threatening clinical situation associated with acute myocardial and vascular dysfunction, whose pathophysiology still poorly understood. Herein, we investigated microRNA-155-dependent mechanisms of dysfunction in septic shock.Prospective, randomized controlled experimental murine study cohort analysis.University research laboratory ICU at tertiary-care center.Septic patients, controls, healthy controls. Postmortem samples from nonseptic patients. Ex vivo evaluation...
Introduction: Cardiac dysfunction is an important outcome predictor in patients with septic shock and lacks effective targeted therapies. MicroRNA-155 (miR-155) a multifunctional microRNA target genes inflammation, immunity cardiovascular system. Hypothesis: The present study assessed the role of miR-155 experimental human sepsis-induced cardiac dysfunction. Methods: Experimental sepsis was induced using endotoxin injection (LPS) or cecal ligation puncture (CLP) models. Genetic loss (miR-155...
Introduction: Septic cardiomyopathy remains a leading cause of death in critically ill patients. Myocardial edema and inflammatory cell recruitment to cardiac interstitial space are proposed mechanisms underlying sepsis-induced contractile dysfunction. Hypothesis: Evaluate the role endothelial microRNA-155 (miR-155) experimental septic cardiomyopathy. Methods: Experimental sepsis was induced using LPS injection WT (n=20) miR-155-/- (KO; n=20) male mice. Cardiac function evaluated through...
A 59-year-old female patient with breast cancer (ductal carcinoma in situ ), treated chemotherapy, radiation therapy and hormone as relevant past medical history. During follow-up oncology consultation, the presented cough underwent a chest X-ray thoracic computed tomography that revealed fracture embolization of intravascular portion central venous catheter to right pulmonary artery (Figures 1A 1B). The was referred cardiac catheterization lab for percutaneous removal [...]