A5057969821- Nerve injury and regeneration
- Axon Guidance and Neuronal Signaling
- Acute Myeloid Leukemia Research
- Erythropoietin and Anemia Treatment
- Neurogenesis and neuroplasticity mechanisms
- Cancer Genomics and Diagnostics
- Iron Metabolism and Disorders
- Neurofibromatosis and Schwannoma Cases
- Viral-associated cancers and disorders
- Immunodeficiency and Autoimmune Disorders
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Intensive Care Unit Cognitive Disorders
- Peripheral Artery Disease Management
- S100 Proteins and Annexins
- Cancer, Hypoxia, and Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Acute Ischemic Stroke Management
- PI3K/AKT/mTOR signaling in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Chronic Lymphocytic Leukemia Research
- Vitamin C and Antioxidants Research
- Hemoglobinopathies and Related Disorders
Royal Marsden Hospital
2019-2024
Universidade do Porto
2008-2022
Genomics (United Kingdom)
2019
MRC Laboratory for Molecular Cell Biology
2010-2018
University College London
2010-2018
Abstract Hepcidin is the principal iron regulatory hormone, controlling systemic absorption and remobilization of from intracellular stores. Recent in vivo studies have shown that hepcidin down-regulated by erythropoiesis, anemia, hypoxia, which meets need input for erythrocyte production. Erythropoietin (EPO) primary signal triggers erythropoiesis anemic hypoxic conditions. Therefore, a direct involvement EPO regulation can be hypothesized. We report here expression EPO, dose-dependent...
ABSTRACT Peripheral nerves are highly regenerative, in contrast to the poor regenerative capabilities of central nervous system (CNS). Here, we show that adult peripheral nerve is a more quiescent tissue than CNS, yet all cell types within proliferate efficiently following injury. Moreover, whereas oligodendrocytes produced throughout life from precursor pool, find corresponding system, myelinating Schwann (mSC), does not turn over adult. However, injury, mSCs can dedifferentiate...
Schwann cells are highly plastic that dedifferentiate to a progenitor-like state following injury. However, deregulation of this plasticity, may be involved in the formation neurofibromas, mixed-cell tumors cell (SC) origin arise upon loss NF1. Here, we show adult myelinating SCs (mSCs) refractory Nf1 loss. context injury, Nf1-deficient display opposing behaviors along wounded nerve; distal Nf1−/− mSCs redifferentiate normally, whereas at wound site give rise neurofibromas both Nf1+/+ and...
Early outcome prediction after acute ischemic stroke (AIS) might be improved with blood-based biomarkers. We investigated whether the longitudinal profile of a multi-marker panel could predict successfully recanalized AIS patients.We used ultrasensitive single-molecule array (Simoa) to measure glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), total-tau (t-tau) and ELISA for brevican in prospective study patients anterior circulation large vessel occlusion submitted...
Septic shock is a life-threatening clinical situation associated with acute myocardial and vascular dysfunction, whose pathophysiology still poorly understood. Herein, we investigated microRNA-155-dependent mechanisms of dysfunction in septic shock.Prospective, randomized controlled experimental murine study cohort analysis.University research laboratory ICU at tertiary-care center.Septic patients, controls, healthy controls. Postmortem samples from nonseptic patients. Ex vivo evaluation...
Summary We report on a study of next‐generation sequencing in 257 patients undergoing investigations for cytopenias. sequenced bone marrow aspirates using target enrichment panel comprising 82 genes and used T cells from paired blood as control. One hundred sixty had idiopathic cytopenias, 81 myeloid malignancies 16 lymphoid or other diagnoses. Forty‐seven the 160 with cytopenias evidence somatic pathogenic variants consistent clonal Only 39 tested were mutated 241 either neoplasms. confirm...
Introduction: Septic cardiomyopathy remains a leading cause of death in critically ill patients. Myocardial edema and inflammatory cell recruitment to cardiac interstitial space are proposed mechanisms underlying sepsis-induced contractile dysfunction. Hypothesis: Evaluate the role endothelial microRNA-155 (miR-155) experimental septic cardiomyopathy. Methods: Experimental sepsis was induced using LPS injection WT (n=20) miR-155-/- (KO; n=20) male mice. Cardiac function evaluated through...
Background/Aims: Hepcidin is the main iron regulatory hormone, controlling systemic absorption and remobilization of from stores. I n vivo studies showed that hepcidin down‐regulated by erythropoiesis, anemia hypoxia, which conforms to need for input erythrocyte production. The hormone erythropoietin (EPO) primary signal triggering erythropoiesis in hypoxia. Therefore, a direct involvement regulation can be hypothesized. aim this study was test effect EPO on expression vitro begin...