A5004706506- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Enzyme Catalysis and Immobilization
- Crystallography and molecular interactions
- Microbial Metabolic Engineering and Bioproduction
- Analytical Chemistry and Chromatography
- Asymmetric Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- Asymmetric Hydrogenation and Catalysis
- Pharmacology and Obesity Treatment
- Catalytic Alkyne Reactions
- Lipid metabolism and biosynthesis
- Organophosphorus compounds synthesis
- Catalytic C–H Functionalization Methods
- Organic Chemistry Cycloaddition Reactions
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Pancreatic function and diabetes
- Catalytic Cross-Coupling Reactions
- Chemical Reaction Mechanisms
- Sphingolipid Metabolism and Signaling
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Molecular spectroscopy and chirality
- Pharmacogenetics and Drug Metabolism
Centrale Marseille
2007-2020
Centre National de la Recherche Scientifique
2007-2020
Aix-Marseille Université
1996-2016
Institut des Sciences Moléculaires de Marseille
2010-2016
Catalyse
1994-2009
University of Neuchâtel
2006
Institut de Chimie
2006
Architecture et Fonction des Macromolécules Biologiques
2003
École Normale Supérieure - PSL
2002
Laboratoire de Synthèse Organique
1999-2000
The synthesis of phosphorus molecules presenting a chiral center on the P‐atom, also known as P‐stereogenic compounds, has long attracted curiosity scientific community. Indeed, these chemical compounds feature many peculiar properties, allowing their use in various fields applications, ranging from medicine to enantioselective catalysis. However, synthesis, and more particularly introduction retention information center, remains very challenging task. That is why this review article focuses...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparative, enzymic synthesis of linoleic acid (13S)-hydroperoxide using soybean lipoxygenase-1Gilles Iacazio, Georges Langrand, Jacques Baratti, Gerard Buono, and Christian TriantaphylidesCite this: J. Org. Chem. 1990, 55, 5, 1690–1691Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/jo00292a056https://doi.org/10.1021/jo00292a056research-articleACS...
We now report that a dynamic combinatorial selection approach can quantitatively provide, from trivial building blocks, an architecturally complex organic material, in which carbon dioxide is reversibly but covalently incorporated as guest with mass content of 20%. Solid-state analyses combined covalent disconnection and quantization the liberated components allowed identification three-component monomeric unit repeated within range assembled oligomeric adducts whose repartition binding...
A series of [RuCl<sub>2</sub>(η<sup>6</sup>-<italic>p</italic>-cymene)] complexes bearing phosphinous acid (PA) ligands have been straightforwardly prepared from the dimer [RuCl<sub>2</sub>(<italic>p</italic>-cymene)]<sub>2</sub>and secondary phosphine oxides (SPOs) and fully characterized.
AbstractThe optimization of 13-S-hydroperoxy-9Z, 11E-octadecadienoic acid synthesis is described using lipoxygenase-1 from soybeans at high substrate concentration. The optimal values the tested parameters are as follows: oxygen pressure 2.5 bar, temperature 5°C, pH 11, enzyme concentration 4 mg/ml and 0.1 M. All these were used in a single reaction, allowing chemoenzymatic gram amounts (+)-coriolic (99%, e.e. 97%) with 54% yield starting linoleic acid.Key Words: Soybean...
In the present study, we propose a continuous assay for screening of sn-2 lipases by using triacylglycerols (TAGs) from Aleurites fordii seed (tung oil) and synthetic TAG containing α-eleostearic acid at position oleic (OA) sn-1 sn-3 positions [1,3-O-dioleoyl-2-O-α-eleostearoyl-sn-glycerol (sn-OEO)]. Each was coated into microplate well, lipase activity measured optical density increase 272 nm due to transition adsorbed soluble state. The sn-1,3-regioselective human pancreatic (HPL), LIP2...
Abstract A new metal‐catalyzed addition reaction of 1,3‐diketones to ynamides, which provides access unprecedented alkoxy‐substituted enamides, is disclosed herein. screening catalytic systems showed that both a phosphapalladacycle and cationic gold complex were capable promoting this rapidly cleanly. The scope investigation revealed variously substituted terminal ynamides cyclic 1,3‐diones well tolerated. use internal led the formation E Z isomers with low good selectivities. proposed...
Platinkomplexe von phosphinigen Säuren vermitteln eine effiziente intermolekulare Tandemsequenz aus [2+1]- und [3+2]-Cycloadditionen. Diese Prozesse öffnen den Zugang zu neuartigen tricyclischen Systemen, sie verlaufen zudem regio- diastereoselektiv (siehe Schema; Cy=Cyclohexyl). Für die [3+2]-Cycloaddition wurden weiterhin zwei verschiedene Alkinpartner eingesetzt.
Galactosylceramide (GalCer) is a glycosphingolipid (GSL) receptor that allows HIV-1 infection of CD4-negative cells from neural and intestinal tissues. A water-soluble analogue GalCer features its polar head the characteristic galactose–ceramide linkage but lacks carbohydrate chains was prepared as single enantiomer (S)-serine. This not recognized in binding tests with surface envelope glycoprotein gp120 solution, which revealed crucial importance ceramide alkyl chains. Two series analogues...
Abstract Whereas the reaction of norbornadiene with terminal alkynes in presence a phosphapalladacycle catalyst leads to formation hydroalkynation products, use phosphinous acid–phosphinito‐containing palladium complexes gives rise formal [2+1] cycloadducts. An experimental and computational approach was employed study mechanisms palladium‐promoted cycloaddition. On one hand, experiments highlight crucial role acidolysis steps on catalytic activities. other DFT calculations demonstrate...