A5043183940- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Ion channel regulation and function
- Circadian rhythm and melatonin
- Traumatic Brain Injury Research
- Sleep and related disorders
- Metabolism and Genetic Disorders
- 14-3-3 protein interactions
- Memory and Neural Mechanisms
- Biomedical and Engineering Education
- Genetics, Bioinformatics, and Biomedical Research
- Glioma Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
University of Iowa
2017-2021
Winona State University
2014
Mayo Clinic
2014
Hepatocellular carcinoma (HCC) is a devastating cancer increasingly caused by non-alcoholic fatty liver disease (NAFLD). Disrupting the Mitochondrial Pyruvate Carrier (MPC) in mice attenuates NAFLD. Thus, we considered whether MPC disruption also prevents HCC. Here, use N-nitrosodiethylamine plus carbon tetrachloride model of HCC development to test how liver-specific knock out affects hepatocellular tumorigenesis. Our data show that ablation markedly decreases tumorigenesis and...
How would you describe a scientist? When asked this question, many of us envision wild-haired, brainy, and slightly awkward sorts characters. In survey my Facebook friends, I found that people rarely give scientists descriptors like great orators or teachers. This problem points to weakness in key component being scientist following the process scientific method – communication. one graduate courses, we were interview faculty member about how they communicate science various audiences. chose...
Acid-sensing ion channels (ASICs) are abundantly expressed in the nucleus accumbens core (NAcore), a region of mesolimbocortical system that has an established role regulating drug-seeking behavior. Previous work shows single dose cocaine reduced AMPA-to-NMDA ratio Asic1a-/- mice, effect observed after withdrawal wild-type whereas ASIC1A overexpression NAcore rats decreases self-administration. However, whether alters measures behavior self-administration period is unknown. To examine this...
Significance The unique aspects of brain mitochondria composition and function are incompletely understood, new approaches required to understand their relationship. We addressed this challenge through a dual-process isolation procedure that yields both semipure suitable for functional studies but not protein localization ultrapure determining functionally compromised. observed contrary the published literature, N-methyl-D-aspartate receptor, ryanodine receptor 1, glyceraldehyde 3-phosphate...
Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21) and correlated with various comorbidities, including Alzheimer’s disease in 50% affected individuals. The Tc1 mouse model contains a copy Hsa21, producing an animal DS. In effort to understand the correlation between DS disease, this study evaluated learning, memory, hippocampal cortical brain morphology model. Genotyping mice indicated that Hsa21 was transmitted 16.67% frequency. underwent open field, dark‐light, step...
Whether through a family member with depression, friend anxiety, or in our own life, psychiatric disorders likely have affected all of us. Intrigued by their prevalence and complexity, scientists spent decades trying to understand what causes how help people them. These scientific efforts pinpointed small difference the blueprint cells that was linked large variety - this link found gene called <i>CACNA1C</i>. My laboratory's research studies gene's job brain cells. Our work has shown...
Ca v 1.2 is the predominant voltage‐gated L‐type calcium (Ca 2+ ) channel (LTCC) in brain and a major regulator of intracellular levels. The CACNA1C gene, which encodes voltagesensing ion conducting α1 subunit 1.2, has been linked to an array chronic, progressive neurological disorders. Previously, we reported that newborn neurons adult dentate gyrus forebrain‐specific knockout (KO) mice survive at two‐fold less rate relative wild‐type (WT) littermates despite exhibiting no differences...