A5083317554- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Hearing, Cochlea, Tinnitus, Genetics
- Olfactory and Sensory Function Studies
- Diet, Metabolism, and Disease
- Neuroscience and Neuropharmacology Research
- Animal Vocal Communication and Behavior
- Traumatic Brain Injury Research
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- melanin and skin pigmentation
- Kruppel-like factors research
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Hydraulic flow and structures
- Marine animal studies overview
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Hydrology and Sediment Transport Processes
- Tryptophan and brain disorders
- Zebrafish Biomedical Research Applications
- Advanced Neuroimaging Techniques and Applications
University School
2024
Case Western Reserve University
2020-2024
Northeast Ohio Medical University
2021-2023
Louis Stokes Cleveland VA Medical Center
2020-2022
University Hospitals of Cleveland
2022
Geriatric Research Education and Clinical Center
2020-2021
Washington State University
2014-2020
The University of Texas at Austin
2016-2018
Leptin acts in the hippocampus to enhance cognition and reduce depression anxiety. Cognitive emotional disorders are associated with abnormal hippocampal dendritic spine formation synaptogenesis. Although leptin has been shown induce synaptogenesis hypothalamus, its effects on mechanism(s) involved not well understood. Here we show that receptors (LepRs) critical for vivo because db/db mice lacking long form of receptor (LepRb) have reduced density CA1 CA3 neurons. promotes mature spines...
Leptin is a critical neurotrophic factor for the development of neuronal pathways and synaptogenesis in hypothalamus. receptors are also found other brain regions, including hippocampus, postnatal surge leptin correlates with time rapid growth dendritic spines synapses hippocampus. normal hippocampal spine formation as db/db mice, which lack receptor signaling, have reduced number vivo. positively influences behaviors, such cognition, anxiety, depression, critically dependent on number. What...
Significance Chronic neurodegeneration, a major cause of the long-term disabilities that afflict survivors traumatic brain injury (TBI), is linked to an increased risk for late-life neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s vascular dementia, and chronic encephalopathy. Here, we report on restoration blood–brain barrier (BBB) structure function by P7C3-A20 when administered 12 mo after TBI. This pharmacotherapy was associated with cessation neurodegeneration...
Progression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in mice triggers persisting 17 months later, equivalent to many human decades. We show increased mouse related levels 1 protein (Fis1) and Fis1 also TBI. Pharmacologically preventing from binding its partner, dynamin-related (Drp1), for 2 weeks normalizes the balance fission/fusion...
Abstract Neurodegenerative lesions induce sprouting of new collaterals from surviving axons, but the extent to which this form axonal remodelling alters brain functional structure remains unclear. To understand how collateral proceeds in adult brain, we imaged post-lesion cerebellar climbing fibres (CFs) mice using vivo time-lapse microscopy. Here show that newly sprouted CF innervate multiple Purkinje cells (PCs) over several months, with most innervations emerging at 3–4 weeks post lesion....
Abstract Granule cells (GCs) in the cerebellar cortex are important for sparse encoding of afferent sensorimotor information. Modeling studies show that GCs can perform their function most effectively when they have four dendrites. Indeed, mature short dendrites on average, each terminating a claw-like ending receives both excitatory and inhibitory inputs. Immature GCs, however, significantly more dendrites—all without claws. How these redundant refined during development is largely unclear....
Abstract The principal neurons (PNs) of the lateral superior olive nucleus (LSO) are an important component mammalian brainstem circuits that compare activity between two ears and extract intensity timing differences used for sound localization. There LSO PN transmitter types, glycinergic glutamatergic, which also have different ascending projection patterns to inferior colliculus (IC). Glycinergic PNs project ipsilaterally while glutamatergic one's projections vary in laterality by species....
Abstract Sound localization critically relies on brainstem neurons that compare information from the two ears. The conventional role of lateral superior olive (LSO) is extraction intensity differences; however, it increasingly clear relative timing, especially transients, also an important function. Cellular diversity within LSO not well understood may underlie its multiple roles. There are glycinergic inhibitory and glutamatergic excitatory principal in LSO, there some disagreement...
As we get older, various aspects of our bodies start to decline, including brain function. The mechanisms behind the decline in function due aging are still not well understood. blood-brain barrier (BBB) is crucial for maintaining health and homeostasis by controlling both passive active exchange materials between blood brain. This predominantly composed endothelial cells, which deteriorate neurodegenerative disorders. Endothelial cells also highly enriched Kruppel-like factor 4 (KLF4)...
Abstract Background Alzheimer’s disease (AD) currently affects around 6 million Americans and is growing exponentially with our aging population. Impaired homeostasis of nicotinamide adenine dinucleotide (NAD + ) impacts several neurodegenerative diseases, including AD. Aging traumatic brain injury, two the principle causes AD, are also associated impaired NAD homeostasis. Method We measured levels in tissue from different cohorts patients along matched controls, as well 5xFAD mice WT...