A5081713568- Synthetic Organic Chemistry Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organometallic Complex Synthesis and Catalysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalytic Cross-Coupling Reactions
- Carbon dioxide utilization in catalysis
- Chemical Synthesis and Analysis
- biodegradable polymer synthesis and properties
- Asymmetric Hydrogenation and Catalysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Catalytic Alkyne Reactions
- Carbohydrate Chemistry and Synthesis
- Crystallography and molecular interactions
- Click Chemistry and Applications
- Radioactive element chemistry and processing
- Nanomaterials for catalytic reactions
- Catalysis and Hydrodesulfurization Studies
- Fuel Cells and Related Materials
- Molecular Sensors and Ion Detection
- Biochemical and Structural Characterization
- Silicone and Siloxane Chemistry
- Microbial Natural Products and Biosynthesis
- Advanced Polymer Synthesis and Characterization
- Organoboron and organosilicon chemistry
University of Salerno
2015-2024
Centre for Studies in Economics and Finance
2022-2023
University of Naples Federico II
2022-2023
University of Zurich
2008
Institut Català d'Investigació Química
2008
University of New Orleans
2005
University of Miami
2005
N-heterocyclic carbene ligands IMes (1), SIMes (2), IPr (3), SIPr (4), and ICy (5) react with Ni(CO)(4) to give the saturated tricarbonyl complexes Ni(CO)(3)(IMes) (8), Ni(CO)(3)(SIMes) (9), Ni(CO)(3)(IPr) (10), Ni(CO)(3)(SIPr) (11), Ni(CO)(3)(ICy) (12), respectively. The electronic properties of these have been compared their phosphine analogues general formula Ni(CO)(3)(PR(3)) by recording nu(CO) stretching frequencies. While all NHCs are better donors than tertiary phosphines, differences...
The past decade has seen N-heterocyclic carbenes (NHC) emerging as a credible alternative to ubiquitous tertiary phosphines ligands in organic and organometallic chemistry. In many cases NHC have proven more effective than ancillary catalysis, while some they also enable unexpected welcomed chemical routes new products.(1) These initial discoveries paved the way continued search for NHCs able promote and/or unprecedented catalysis. Nevertheless, useful remains an arduous task, because, date,...
Ester-way to heaven: Unexpected formation of bicyclo[3.1.0]hexene 4 was the main focus combined experimental and theoretical studies on Au-catalyzed cycloisomerization branched dienyne 1 (see scheme), which provided better understanding mechanistic details governing cyclization enynes bearing a propargylic ester group.Experimental Au- Pt-catalyzed with an acetate group at position are presented. The peculiar architecture precursor, has both 1,6- 1,5-enyne skeleton, leads, in presence...
The mechanism of enantioselectivity in the asymmetric Ru-catalyzed metathesis olefins is investigated with a theoretical approach. models are based on chiral N-heterocyclic (NHC)-based catalysts developed by Grubbs. Our analysis indicates that origin ring-closing achiral trienes correlated to folding N-bonded aromatic groups, which imposed Ph groups positions 4 and 5 imidazole ring NHC ligand. This catalyst imposes orientation around RuC bond, which, turn, selects between two enantiofaces...
A new class of easily accessible and stable imidazolin-2-ylidenes has been synthesized where the side chains are comprised substituted naphthyl units. Introduction groups generates C 2 -symmetric ( rac) s- symmetric meso) atropisomers, interconversion between isomers is studied in detail both experimentally computationally. Complete characterization carbenes includes rare examples crystallographically characterized saturated NHC structures. Steric properties ligands an investigation their...
Two dinuclear aluminum complexes bearing dinaphthalene bridging Schiff bases have been synthesized and investigated as catalysts in ring-opening polymerization (ROP) of cyclic esters such rac-lactide (rac-LA) ε-caprolactone (ε-CL) the copolymerization (ROCOP) phthalic anhydride (PA) with cyclohexene oxide (CHO) limonene (LO). The polymerizations were living, producing polymers narrow molar mass distributions. Kinetic studies showed that first order respect to monomers. Cooperative effects...
The synthesis of Ru-based precatalysts with N-heterocyclic carbene (NHC) ligands bearing syn- and anti-methyl groups on the NHC backbone aryl N-substituents differing steric bulk was carried out. catalytic behavior monophospine Ru (7a, 7b, 8a, 8b) compared to corresponding family phosphine-free catalysts (9a, 9b, 10a 10b) in ring-closing metathesis (RCM) olefins. These showed high efficiency RCM reactions syn-isomers 7a 9a, particular, proved be among most active formation tetrasubstituted...
A series of Hoveyda–Grubbs second-generation catalysts containing N-alkyl/N′-aryl N-heterocyclic carbene (NHC) ligands were synthesized and investigated in representative olefin metathesis reactions. Steric perturbations unsymmetrical NHCs achieved through modulation the hindrance alkyl (neopentyl, neophyl, cyclohexyl) aryl (2-isopropylphenyl, mesityl) substituents at nitrogen atoms combination with different backbone configurations (syn anti). The NHC substitution patterns strongly...
N-heterocyclic carbene silver and gold complexes active in A 3 -coupling (aldehyde–alkyne–amine) reactions green conditions.
The synthesis of Ru-based catalysts, presenting saturated chiral C2 symmetric (3, 5) and C1 (4) N-heterocyclic carbene (NHC) ligands bearing N-(S)-phenylethyl groups, was carried out. Variable-temperature NMR studies were conducted to investigate the interconversion atropisomers in solution. complex behaviors rationalized evaluating rotation barrier alkylidene NHC groups around C−Ru bonds, by DFT calculations. Comparison between data calculations suggested that different atropisomers, which...
The synthesis and characterization of two ruthenium-based olefin metathesis catalysts bearing N-heterocyclic carbene (NHC) ligands with syn (12) anti (13) methyl groups on the backbone o-tolyl N-substituents are reported. catalytic performance both 12 13 has been evaluated in ring-closing metathesis, ring-opening polymerization, cross-metathesis reactions. results have compared to those obtained presence Grubbs second-generation catalyst 3a, lacking substituents NHC backbone. Of particular...
The synthesis of a new stable palladium(II) complex (3) featuring an unsymmetrical substituted N-heterocyclic carbene (NHC) ligand with pendant hydroxy-functionalized group was successfully accomplished via transmetalation the corresponding bis-NHC silver(I) (2). Solid-state structures both 2 and 3 were determined by single-crystal X-ray diffraction. catalytic behaviour in direct regioselective arylation furan thiophene derivatives using challenging aryl halides studied, revealing that...
The catalytic behavior of Grubbs and Hoveyda–Grubbs II type ruthenium complexes bearing N-heterocyclic carbene (NHC) ligands with syn-phenyl groups on the backbone syn- or anti-oriented o-tolyl N-substituents was evaluated in a series olefin metathesis transformations. Further advance synthesis best-performing syn catalysts deeper investigation into solution-state structure complex anti N-tolyl by 2D-NMR DFT studies are also reported. Of particular interest, emerged among all explored...
In recent years, the number of people suffering from cancer has risen rapidly and World Health Organization U.S. European governments have identified this pathology as a priority issue. It is known that most bioactive anticancer molecules do not target single protein but exert pleiotropic effects, simultaneously affecting multiple pathways. our study, we designed synthesized new series silver N-heterocyclic carbene (NHC) complexes [(NHC)
Cat power: Judicious backbone substitution of N-heterocyclic carbenes (NHCs) leads to stable Ru metathesis catalysts with frozen NHC conformations. This finding not only permits the isolation complexes that are among most active in ring-closing hindered olefins (see graphic; Ts=p-toluenesulfonyl), but also provides fundamental mechanistic insights on role N-aryl substituent conformations catalyst activity. As a service our authors and readers, this journal supporting information supplied by...
New second generation ruthenium catalysts bearing unsymmetrical NHCs show different catalytic efficiencies depending on the size of <italic>N</italic>-alkyl group (methyl or cyclohexyl) and backbone configuration.
Cyclic peptoids have recently emerged as important examples of peptidomimetics for their interesting complexing properties and innate ability to permeate biological barriers. In the present contribution, experimental theoretical data evidence intricate conformational stereochemical five novel hexameric decorated with N-isopropyl, N-isobutyl, N-benzyl substituents. Complexation studies by NMR, in presence sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (NaTFPB), calculations,...
Conformational chirality is an emerging and neglected property of rigid cyclic peptoids determining structural, catalytic, biological properties. The present contribution analyzes its impact sets the configurational rules to define it.
Abstract The synthesis and characterization of a zirconium complex, having two alkoxide functionalized N ‐heterocyclic carbene ligands, its behavior as catalyst in the polymerization ethylene propylene, have been reported. NMR analysis showed that more than one species was obtained during synthesis. These data were confirmed by gave rise to linear polyethylene high Molecular weight polydispersity index (MDI) > 2 often bimodal. same catalytic system able produce highly isotactic...