A5048986908- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Carbohydrate Chemistry and Synthesis
- Advanced Data Processing Techniques
- Organometallic Complex Synthesis and Catalysis
- Catalysis and Oxidation Reactions
- Carbon dioxide utilization in catalysis
- Synthesis and Catalytic Reactions
- Machine Learning in Materials Science
- Organoboron and organosilicon chemistry
- Asymmetric Synthesis and Catalysis
- Fuel Cells and Related Materials
University of Warsaw
2017-2023
University of Białystok
2015
Macrocyclic lactones, ketones, and ethers can be obtained in the High-Concentration Ring-Closing Metathesis (HC-RCM) reaction high yield selectivity at concentrations 40 to 380 times higher than those typically used by organic chemists for similar macrocyclizations. The new method consists of using tailored ruthenium catalysts together with applying vacuum distill off macrocyclic product as it is formed metathetical backbiting oligomers. Unlike classical RCM, no large quantities solvents are...
A series of Hoveyda–Grubbs second-generation catalysts containing N-alkyl/N′-aryl N-heterocyclic carbene (NHC) ligands were synthesized and investigated in representative olefin metathesis reactions. Steric perturbations unsymmetrical NHCs achieved through modulation the hindrance alkyl (neopentyl, neophyl, cyclohexyl) aryl (2-isopropylphenyl, mesityl) substituents at nitrogen atoms combination with different backbone configurations (syn anti). The NHC substitution patterns strongly...
Abstract Helical chirality is a novel enantioselectivity‐inducing property in transition‐metal‐catalyzed transformations. The principle illustrated herein for the example of asymmetric olefin metathesis. This work reports synthesis first helically chiral Ru‐NHC alkylidene complex from an aminohelicene‐derived imidazolium salt, which was ligated to generation Hoveyda–Grubbs catalyst. Kinetic data were acquired benchmark test reactions and compared achiral Ru‐catalyst evaluated ring‐closing...
High yielded and selective synthesis of macrocyclic unsaturated musk compounds from unbiased dienes using reactive distillation at high concentration.
Robust, selective, and stable in the presence of ethylene, ruthenium olefin metathesis pre-catalyst, {[3-benzyl-1-(10-phenyl-9-phenanthryl)]-2-imidazolidinylidene}dichloro(o-isopropoxyphenylmethylene)ruthenium(II), Ru-3, bearing an unsymetrical N-heterocyclic carbene (uNHC) ligand, has been synthesized. The initiation rate Ru-3 was examined by ring-closing cross-metathesis reactions with a broad spectrum olefins, showing unprecendented selectivity. It also tested industrially relevant...
The ROCM reactions of exo - and endo -2-cyano-7-oxanorbornenes with allyl alcohol or acetate promoted by different ruthenium alkylidene catalysts were studied. stereochemical outcome the was established. issues concerning chemo- (ROCM vs ROMP), regio- (1-2- 1-3-product formation), stereo- ( E / Z isomerism) selectivity under various conditions are discussed. Surprisingly good yields products obtained neat conditions.
Olefin metathesis reactions of diverse polyfunctional substrates were conducted in water emulsions using two hydrophobic ruthenium catalysts the presence air. Instead surfactants to increase efficiency reaction water, ultrasound and microwave techniques tested on a small-scale reaction, whereas conventional heating mechanical stirring effective enough provide high conversion selectivity larger scale. The developed conditions extend known protocols for aqueous methodology, utilizing...