A5080423650- Lipoproteins and Cardiovascular Health
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Berberine and alkaloids research
- Circular RNAs in diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Medical and Biological Ozone Research
- Essential Oils and Antimicrobial Activity
- Pharmacogenetics and Drug Metabolism
- Bee Products Chemical Analysis
- Chemotherapy-induced organ toxicity mitigation
- RNA modifications and cancer
- Natural Antidiabetic Agents Studies
- Sports Performance and Training
- Computational Drug Discovery Methods
- Tryptophan and brain disorders
- RNA Research and Splicing
- Diabetes Treatment and Management
- Ethnobotanical and Medicinal Plants Studies
- Body Composition Measurement Techniques
- Genetics, Bioinformatics, and Biomedical Research
Hospital Clínic de Barcelona
2021-2022
University of Chile
2018-2021
Universidad de La Frontera
2010-2020
Universidade de São Paulo
2015
The role of gut microbiota in the development metabolic illnesses has been abundantly demonstrated. Recent studies suggest that alterations may also be related to hypercholesterolemia. Therefore, we aimed assess differences bacterial community profiles between hypercholesterolemic subjects and controls. Thirty cases diagnosed with hypercholesterolemia 27 normocholesterolemic controls were included. A fasting whole blood sample was obtained determine lipid profile. In parallel, stool samples...
Tooth decay is an infectious disease, whose main causative agent identified Streptococcus mutans ( S. ). Diverse treatments have been used to eradicate this microorganism, including propolis. To date, it has shown that polyphenols from Chilean propolis inhibit growth and biofilm formation. However, the molecular mechanisms underlying process are unclear. In present study, we assessed effect of on expression activity glycosyltransferases enzymes their related genes. Polyphenol-rich extract...
Genetic factors can determine the high variability observed in response to lipid-lowering therapy with statins. Nonetheless, frequency of single nucleotide polymorphisms (SNPs) and their impact vary due ethnicity. Because Chilean population carries a strong Amerindian background, objective this study was evaluate influence apolipoprotein E (APOE) variants (rs429358, rs7412) 1959C>T SNP (rs5925) low-density lipoprotein receptor (LDLR) atorvastatin treatment hypercholesterolemic...
Polyphenols from diverse sources have shown anti-inflammatory activity. In the context of atherosclerosis, macrophages play important roles including matrix metalloproteinases synthesis involved in degradation extracellular components affecting atherosclerotic plaque stability. We prepared a propolis extract and pinocembrin ethanol solution. Propolis was chemically characterized using LC-MS. The effect treatments on gene expression proteolytic activity measured vitro murine activated with...
The use of statins as the preferred lipid-lowering therapy has clearly demonstrated its efficacy in treatment hypercholesterolemia, reducing also risk coronary events and cardiovascular disease mortality. In this study, we assessed single nucleotide polymorphisms (SNPs) SLCO1B1 gene their effect on atorvastatin response. We included 129 Chilean hypercholesterolemic patients undergoing 10 mg/day during 4 weeks. Lipid profile was determined before after drug administration. Genotyping...
Abstract Lipid‐lowering response to statin therapy shows large interindividual variability. At a genome‐wide significance level, single nucleotide polymorphisms ( SNP s) in PCSK 9 and HMGCR have been implicated this differential response. However, the influence of these variants is uncertain Chilean population. Hence, we aimed evaluate contribution rs7552841 rs17671591 s as genetic determinants atorvastatin hypercholesterolaemic individuals. One hundred one patients received 10 mg/day for 4...
Statins are first-line therapy for reducing high cholesterol levels. However, response to these drugs shows interindividual variability. We aimed investigate the influence of two single nucleotide polymorphisms (SNP) (ABCB1 rs1128503 and ABCG2 rs2231142) in ABC transporter genes on short-term low-dose atorvastatin Chilean hypercholesterolaemic patients.We studied 127 patients treated with 10 mg/d 4 weeks. The lipid profile was determined before after drug administration. Genotyping rs2231142...
Statins are the first-line therapy prescribed to lower plasma cholesterol levels. Although being safe and showing several beneficial cholesterol-independent pleiotropic effects, a significant variability regarding statin's therapeutic goals has been abundantly documented, but less understood. We aimed investigate influence of ABCC2 -24C>T single nucleotide polymorphism on Chilean hypercholesterolaemic individuals treated for 4 weeks with 10 mg/day atorvastatin. A total 127 medicated...
Atorvastatin is extensively used to treat hypercholesterolemia. However, the wide interindividual variability observed in response this drug still needs further elucidation. Nowadays, biology of long non-coding RNAs (lncRNAs) better understood, and some these molecules have been related cholesterol metabolism. Therefore, they could provide additional information on statins. The objective research was evaluate effect atorvastatin three lncRNAs (lncRNA ARSR: Activated renal cell carcinoma...
Background: Breast cancer (BRCA) and prostate (PRCA) are the most commonly diagnosed types in Latin American women men, respectively. Although recent years large-scale efforts from international consortia have focused on improving precision oncology, a better understanding of genomic features BRCA PRCA developing regions racial/ethnic minority populations is still required. Methods: To fill this gap, we performed integrated silico analyses to elucidate oncogenic variants driver genes;...
Objective: To objective of this work was to perform phytochemical qualitative and quantitative analyzes the main secondary metabolites in root Berberis microphylla.Methods: The extracts B. microphylla were tested through screening quantification most important constituents carried out using spectrophotometric gravimetric techniques.Results: Phytochemical both showed presence alkaloids, flavonoids, glycosides, cardiac saponins, terpenes,and tannins, which are pharmacologically important....
Clopidogrel is an antiplatelet drug especially used in patients undergoing percutaneous coronary interventions (PCI). Polymorphisms within CYP2C19 can result important interindividual variations regarding therapeutic efficacy. Therefore, we aimed to evaluate the impact of CYP2C19<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:msup><mml:mrow /><mml:mrow><mml:mo>⁎</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>2 variant (rs4244285) on in-stent restenosis...