A5033521789- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Biochemical and Molecular Research
- CRISPR and Genetic Engineering
- Vitamin K Research Studies
Keio University
2015-2024
Keio University Shonan Fujisawa
2024
The University of Tokyo
2020-2024
Abstract Intravenous administration of high-dose vitamin C has recently attracted attention as a cancer therapy. High-dose induces pro-oxidant effects and selectively kills cells. However, the anticancer mechanisms are not fully understood. Here, we analyzed metabolic changes induced by in MCF7 human breast adenocarcinoma HT29 colon cells using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). The metabolomic profiles both cell lines were dramatically altered after...
Abstract Epithelial–mesenchymal transition (EMT)—a fundamental process in embryogenesis and wound healing—promotes tumor metastasis resistance to chemotherapy. While studies have identified signaling components transcriptional factors responsible the TGF-β-dependent EMT, whether how intracellular metabolism is integrated with EMT remains be fully elucidated. Here, we showed that TGF-β induces reprogramming of amino acid metabolism, which necessary promote non-small cell lung cancer cells....
Epithelial‐to‐mesenchymal transition (EMT) contributes to the poor prognosis of patients with cancer by promoting distant metastasis and anti‐cancer drug resistance. Several distinct metabolic alterations have been identified as key EMT phenotypes. In present study, we further characterize role transforming growth factor‐β (TGF‐β)‐induced in non‐small‐cell lung cancer. Our study revealed that TGF‐β plays a functions upregulation cytidine 5′‐triphosphate synthetase 1 (CTPS), vital enzyme for...