A5102812609- Orthopedic Surgery and Rehabilitation
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Urologic and reproductive health conditions
- Orthopedic Infections and Treatments
- Eosinophilic Disorders and Syndromes
- Potassium and Related Disorders
- Gastroesophageal reflux and treatments
- Bone Metabolism and Diseases
- Inflammatory Myopathies and Dermatomyositis
- Foot and Ankle Surgery
- Cardiac tumors and thrombi
- Bone fractures and treatments
- Pancreatic and Hepatic Oncology Research
- Skin Diseases and Diabetes
- Urological Disorders and Treatments
- Oral and Maxillofacial Pathology
- Nail Diseases and Treatments
- Liver Diseases and Immunity
- Sarcoidosis and Beryllium Toxicity Research
- Sarcoma Diagnosis and Treatment
- Shoulder Injury and Treatment
- Genetic factors in colorectal cancer
- Chronic Myeloid Leukemia Treatments
- Esophageal and GI Pathology
Toho University
2018-2025
Hiroshima University
2025
Tochigi Cancer Center
2024
Jichi Medical University
2019-2023
Jichi Medical University Hospital
2019-2023
Jichi Medical University Saitama Medical Center
2023
Weatherford College
2021
Clinical Orthopaedics and Related Research
2019
Creative Commons
2019
Toho University Omori Medical Center
2018
The utility of vancomycin powder to prevent surgical site infection, mainly in spinal surgery, has been widely examined, and the local administration wounds reported be effective preventing infections after spine surgery. However, vitro studies have shown that high concentrations may inhibit osteogenesis, although it remains unclear how these influence osteoblasts. No candidate drug recover cytotoxicity with vancomycin, but we suggest vitamin D3, which induces osteoblast proliferation,...
Krüppel-like factor 5 (KLF5) is a potential target for anticancer drugs. However, as an intrinsically disordered protein (IDP) whose tertiary structure cannot be solved, innovative strategies are needed. We focused on its hydrophobic α-helix structure, defined induced helical motif (IHM), which possible interface protein–protein interaction. Using mathematical analyses predicting the α-helix's and hydrophobicity, 4-amino-acid site (V-A-I-F) was identified IHM. Low-molecular-weight compounds...
Background and Aims: The incidence of erosive esophagitis in emergent endoscopy for upper gastrointestinal bleeding is not rare but the clinical endoscopic findings have been fully investigated. aim present study was to clarify features acute cases showing onset severe findings. Methods: We defined that endoscopically showed circumferential diffuse mucosal lesion involving at least entire lower third esophagus as esophageal investigated characteristics. Results: experienced six black or dark...
Background and Aims: The incidence of erosive esophagitis in emergent endoscopy for upper gastrointestinal bleeding is not rare but the clinical endoscopic findings have been fully investigated. aim present study was to clarify features acute cases showing onset severe findings. Methods: We defined that endoscopically showed circumferential diffuse mucosal lesion involving at least entire lower third esophagus as esophageal investigated characteristics. Results: experienced...
Abstract Rationale: Primary carcinosarcoma of the upper urinary tract is rare. Ureteral duplication one most common malformations. Additionally, association between ureteral and malignancy unknown. To best our knowledge, no cases malignant tumors diagnosed as with have been reported. We herein report case a patient ureteropelvic junction associated incomplete duplication. Patient concerns: A 60-year-old Japanese woman presented painless gross hematuria. She had history total hysterectomy...
Abstract Rationale: Phagocytosis is an important physiological process for eliminating unnecessary substances or dead cells after tissue damage, such as inflammation infarction. was previously considered to be mainly performed by professional phagocytotic cells, macrophages. In contrast, we demonstrated that the phagocytosis of and myofibroblasts in myocardial Based on our discovery, speculated may a more common pathological phenomenon also other diseases than believed. Patient concerns: A...
Abstract Purpose This study aimed to ascertain the involvement of cancer stem cells (CSCs) in therapy resistance by estimating CSC markers, niche factors, and WNT/β-catenin-relating molecules untreated chemoradiation-treated (CRT) rectal cancer. Methods Expression ratios leucine-rich repeat-containing G protein-coupled receptor 5 (LGR), proto-oncogene polycomb ring finger 1 (BMI1), yes-associated transcriptional regulator (YAP) its paralog TAZ (hereafter; YAP/TAZ), nuclear β-catenin were...
Complex regional pain syndrome (CRPS) complicated with septic arthritis of the hand has not previously been described. We treated a patient in whom swelling wrist recurred during treatment CRPS and was induced by group G hemolytic streptococcus. There are case reports tuberculous CRPS; however, causal relationship joint inflammation is unclear. Careful follow-up necessary for if relapses wrist.
Suppression and of cancer metastasis is one the most important issues in care. Considering typical clinical course metastases, cells might prefer certain environments or conditions. However, favorable for have not been clearly identified. We had previously described a case dual, yet separate, pancreatic colon cancer, which metastatic was localized at invasive portion cancer. hypothesized that took over microenvironment.We experienced an another double 65-year-old man who lung squamous cell...
Intrawound vancomycin powder is effective in preventing surgical site infection after spine surgery. In a previous study, vancomycin-induced cytotoxicity osteoblasts was investigated vitro, and vitamin D3 verified to be candidate drug aiding recovery from cytotoxicity. The treatment practices involving osteogenesis-promoting drugs vary widely. Teriparatide, an anabolic agent, highly promotes bone formation by inducing osteoblast activation, increasing mineral density, vertebral fractures....
Abstract Rationale: Salivary duct carcinoma (SDC) is a rare and highly aggressive cancer with poor prognosis. SDC demonstrates potential for invasive growth early regional distant metastasis to organs, such as bone, lung, liver, brain. Because, adrenal gland from rare, its treatment options are not well established. Herein, we report case of the parotid gland, which was successfully treated by surgery. Patient concerns: The patient had an abnormal but painless lump on right gland. size mass...